Negative Regulation of Rho Family GTPases Cdc42 and Rac2 by Homodimer Formation

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.

1997 • 605 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

A continuous spectrophotometric assay for inorganic phosphate and for measuring phosphate release kinetics in biological systems.

1992 • 527 citations

The Dbl family of oncogenes

1996 • 497 citations

Structure at 1.65 Å of RhoA and its GTPase-activating protein in complex with a transition-state analogue

1997 • 487 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

New ribose-modified fluorescent analogs of adenine and guanine nucleotides available as subtrates for various enzymes

1983 • 403 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Regulation of receptor-mediated endocytosis by Rho and Rac

1996 • 386 citations

Isolation and characterization of the faciogenital dysplasia (Aarskog-Scott syndrome) gene: A putative RhoRac guanine nucleotide exchange factor

1994 • 297 citations

Rho: theme and variations

1996 • 290 citations

Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

1997 • 252 citations

GAPs for rho-related GTPases

1994 • 248 citations

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis.

1996 • 216 citations

Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila.

1996 • 215 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1996 • 201 citations

The Faciogenital Dysplasia Gene Product FGD1 Functions as a Cdc42Hs-specific Guanine-Nucleotide Exchange Factor

1996 • 158 citations

The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways.

1996 • 130 citations

Involvement of the GTP binding protein Rho in constitutive endocytosis in Xenopus laevis oocytes.

1995 • 110 citations

Characterization of the Interactions between the Small GTPase Cdc42 and Its GTPase-activating Proteins and Putative Effectors

1997 • 99 citations

Phosphatidylinositol 4,5-bisphosphate Provides an Alternative to Guanine Nucleotide Exchange Factors by Stimulating the Dissociation of GDP from Cdc42Hs

1996 • 92 citations

Definition of the Switch Surface in the Solution Structure of Cdc42Hs^,

1997 • 82 citations

Regulation of RhoA GTP Hydrolysis by the GTPase-Activating Proteins p190, p50RhoGAP, Bcr, and 3BP-1

1998 • 80 citations

Aluminium fluoride associates with the small guanine nucleotide binding proteins

1997 • 72 citations

Structural Determinants Required for the Interaction between Rho GTPase and the GTPase-activating Domain of p190

1997 • 68 citations

Residues of the Rho Family GTPases Rho and Cdc42 That Specify Sensitivity to Dbl-like Guanine Nucleotide Exchange Factors

1997 • 68 citations

Interaction of Rac1 with GTPase-activating Proteins and Putative Effectors

1998 • 65 citations

Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.

1996 • 58 citations

Analysis of the Mechanisms of Action of the Saccharomyces cerevisiae Dominant Lethal cdc42 G12V and Dominant Negative cdc42 D118A Mutations

1998 • 46 citations

Fluoride Activation of the Rho Family GTP-binding Protein Cdc42Hs

1998 • 42 citations

Turning off the Ras switch with the flick of a finger

1997 • 18 citations