Expression of Ca2+-Permeable AMPA Receptor Channels Primes Cell Death in Transient Forebrain Ischemia

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1994 • 3,989 citations

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Temporal profile of neuronal damage in a model of transient forebrain ischemia

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1999 • 1,897 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

1991 • 1,465 citations

Ca2 ⁺ Permeability of KA-AMPA—Gated Glutamate Receptor Channels Depends on Subunit Composition

1991 • 1,458 citations

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1995 • 1,239 citations

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

1992 • 1,077 citations

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

2001 • 1,073 citations

The Role of Zinc in Selective Neuronal Death After Transient Global Cerebral Ischemia

1996 • 1,057 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability

2001 • 900 citations

Selective vulnerability of the hippocampus in brain ischemia

1991 • 876 citations

Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels

1991 • 827 citations

The TRP Channels, a Remarkably Functional Family

2002 • 822 citations

Mediation by a CREB Family Transcription Factor of NGF-Dependent Survival of Sympathetic Neurons

1999 • 794 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

A Key Role for TRPM7 Channels in Anoxic Neuronal Death

2003 • 770 citations

ZINC AND BRAIN INJURY

1998 • 757 citations

Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury?

2002 • 693 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Disruption of CREB function in brain leads to neurodegeneration

2002 • 674 citations

The GluR2 (GluR-B) hypothesis: Ca2+-permeable AMPA receptors in neurological disorders

1997 • 538 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

RNA editing and death of motor neurons

2004 • 513 citations

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1990 • 498 citations

Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2

1996 • 494 citations

Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats.

1992 • 399 citations

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1979 • 394 citations

A Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal Neurons

2002 • 353 citations

Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels

1995 • 348 citations

Ischemic Insults Derepress the Gene Silencer REST in Neurons Destined to Die

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1987 • 309 citations

Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial

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Global Ischemia Induces Downregulation of Glur2 mRNA and Increases AMPA Receptor-Mediated Ca²⁺Influx in Hippocampal CA1 Neurons of Gerbil

1997 • 295 citations

Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study

1994 • 271 citations

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

2003 • 270 citations

Failure of the competitive N-methyl-d-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two Phase III clinical trials

1999 • 270 citations

Regulation of Brain-Derived Neurotrophic Factor Gene Expression after Transient Middle Cerebral Artery Occlusion with and without Brain Damage

1995 • 248 citations

Ca2+–Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration

2000 • 246 citations

The AMPAR subunit GluR2: still front and center-stage11Published on the World Wide Web on 30 October 2000.

2000 • 244 citations

Expression of Inducible Nitric Oxide Synthase after Focal Cerebral Ischemia Stimulates Neurogenesis in the Adult Rodent Dentate Gyrus

2003 • 210 citations

A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)-regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo.

1992 • 208 citations

Involvement of an Upstream Stimulatory Factor as Well as cAMP-responsive Element-binding Protein in the Activation of Brain-derived Neurotrophic Factor Gene Promoter I

2002 • 206 citations

Termination of Acute Stroke Studies Involving Selfotel Treatment

1997 • 187 citations

Block of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins.

1996 • 172 citations

Blockade of Ca²⁺-Permeable AMPA/Kainate Channels Decreases Oxygen–Glucose Deprivation-Induced Zn²⁺Accumulation and Neuronal Loss in Hippocampal Pyramidal Neurons

2002 • 150 citations

AMPA receptors with high Ca2+ permeability mediate synaptic transmission in the avian auditory pathway.

1995 • 140 citations

GluR2-Dependent Properties of AMPA Receptors Determine the Selective Vulnerability of Motor Neurons to Excitotoxicity

2002 • 140 citations

Generation of Functional Inhibitory Neurons in the Adult Rat Hippocampus

2003 • 138 citations

The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair

1996 • 119 citations

Knockdown of AMPA Receptor GluR2 Expression Causes Delayed Neurodegeneration and Increases Damage by Sublethal Ischemia in Hippocampal CA1 and CA3 Neurons

1999 • 119 citations

Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS

2003 • 117 citations

A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)- regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo

1992 • 99 citations

Regulation of GluR2 promoter activity by neurotrophic factors via a neuron‐restrictive silencer element

2000 • 83 citations

Ischemic preconditioning acts upstream of GluR2 down-regulation to afford neuroprotection in the hippocampal CA1

2002 • 78 citations

Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression

1998 • 67 citations

Overexpression of Ca2+-permeable AMPA receptor promotes delayed cell death of hippocampal CA1 neurons following transient forebrain ischemia

2003 • 44 citations

Temporal profile of CREB phosphorylation after focal ischemia in rat brain

1999 • 42 citations

GluR2 protein synthesis and metabolism in rat hippocampus following transient ischemia and ischemic tolerance induction

2000 • 41 citations

Unchanged balance between levels of mRNA encoding AMPA glutamate receptor subtypes following global cerebral ischemia in the rat.

2009 • 33 citations

γ-Hydroxybutyric acid-induced absence seizures in GluR2 null mutant mice

2001 • 19 citations