Catalytic Role of 2′-Hydroxyl Groups Within a Group II Intron Active Site

An all atom force field for simulations of proteins and nucleic acids

1986 • 3,388 citations

A general two-metal-ion mechanism for catalytic RNA.

1993 • 1,125 citations

STRUCTURE AND ACTIVITIES OF GROUP II INTRONS

1995 • 569 citations

Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

1992 • 466 citations

The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

1986 • 464 citations

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

1992 • 438 citations

Frequent use of the same tertiary motif by self-folding RNAs.

1995 • 354 citations

Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix

1994 • 276 citations

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

1990 • 262 citations

GAAA Tetraloop and Conserved Bulge Stabilize Tertiary Structure of a Group I Intron Domain

1994 • 246 citations

Involvement of a GNRA tetraloop in long-range RNA tertiary interactions

1994 • 241 citations

Multiple magnesium ions in the ribonuclease P reaction mechanism

1993 • 192 citations

RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme

1992 • 182 citations

The Combination of Symbolic and Numerical Computation or Three-Dimensional Modeling of RNA

1991 • 181 citations

Ribozyme recognition of RNA by tertiary interactions with specific ribose 2′-OH groups

1991 • 165 citations

Group II Intron Domain 5 Facilitates a trans-Splicing Reaction

1988 • 161 citations

Minor Groove Recognition of the Conserved G⋅U Pair at the Tetrahymena ribozyme Reaction Site

1995 • 156 citations

Two Competing Pathways for Self-splicing by Group II Introns: A Quantitative Analysis of Reaction Rates and Products

1996 • 127 citations

Catalytic Site Components Common to Both Splicing Steps of a Group II Intron

1994 • 117 citations

Functional contacts of a transfer RNA synthetase with 2′-hydroxyl groups in the RNA minor groove

1992 • 114 citations

Comparison of binding of mixed ribose-deoxyribose analogs of CUCU to a ribozyme and to GGAGAA by equilibrium dialysis: evidence for ribozyme specific interactions with 2'-hydroxy groups

1991 • 108 citations

The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction

1993 • 105 citations

Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme

1993 • 102 citations

Monitoring of the Cooperative Unfolding of the sunY Group I Intron of Bacteriophage T4

1993 • 101 citations

Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA

1993 • 97 citations

Group II intron domain 5 facilitates a trans-splicing reaction.

1988 • 95 citations

Building a Kinetic Framework for Group II Intron Ribozyme Activity: Quantitation of Interdomain Binding and Reaction Rate

1994 • 94 citations

Group II Introns Deleted for Multiple Substructures Retain Self-Splicing Activity

1992 • 92 citations

Catalytically critical nucleotide in domain 5 of a group II intron.

1995 • 92 citations

Self-assembly of a group I intron active site from its component tertiary structural domains.

1995 • 86 citations

The electrostatic contribution to DNA base-stacking interactions

1992 • 79 citations

U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.

1995 • 76 citations

Studies of Point Mutants Define Three Essential Paired Nucleotides in the Domain 5 Substructure of a Group II Intron

1995 • 75 citations

Dissection of the Role of the Conserved G.cntdot.U Pair in Group I RNA Self-Splicing

1994 • 69 citations

Replacement of the Conserved G.cntdot.U with a G-C Pair at the Cleavage Site of the Tetrahymena Ribozyme Decreases Binding, Reactivity, and Fidelity

1994 • 68 citations

Stereochemical Selectivity of Group II Intron Splicing, Reverse Splicing, and Hydrolysis Reactions

1995 • 67 citations

Group II introns deleted for multiple substructures retain self-splicing activity.

1992 • 59 citations

RNA folding

1995 • 39 citations

Kinetic analysis of the 5′ splice junction hydrolysis of a group II intron promoted by domain 5

1993 • 33 citations

Structural Analysis of a Group II Intron by Chemical Modifications and Minimal Energy Calculations

1990 • 14 citations