The NMDA antagonist memantine blocks pain behavior in a rat model of formalin-induced facial pain

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

1987 • 2,156 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin

1987 • 545 citations

Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

2016 • 516 citations

Evidence for spinalN-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat

1990 • 458 citations

The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation

1992 • 422 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

1988 • 363 citations

Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system

1984 • 353 citations

Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels

1989 • 347 citations

Differential effects of excitatory amino acid antagonists on dorsal horn nociceptive neurones in the rat

1990 • 310 citations

Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists

1992 • 301 citations

Intrathecal MK-801 and local nerve anesthesia synergistically reduce nociceptive behaviors in rats with experimental peripheral mononeuropathy

1992 • 286 citations

MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy

1991 • 276 citations

Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord

1983 • 243 citations

The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats

1992 • 242 citations

Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn

1988 • 210 citations

Application of the formalin test to the study of orofacial pain in the rat

1989 • 197 citations

Antinociceptive actions of different classes of excitatory amino acid receptor antagonists in mice

1992 • 177 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

1991 • 145 citations

IntrathecalN-methyl-d-aspartate (NMDA) activates both nociceptive and antinociceptive systems

1987 • 130 citations

Memantine prevents quinolinic acid-induced hippocampal damage

1992 • 55 citations

Role of Symbol and opiate receptors in nociception during and after ischaemia in rats

1992 • 49 citations

Spinal antinociceptive effects of excitatory amino acid antagonists: quisqualate modulates the action of N-methyl-D-aspartate

1990 • 38 citations

An adaptable microcomputer program for recording behavior durations

1990 • 11 citations