The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol*

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

1990 • 451 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

Analysis of the CYP2D6 gene in relation to debrisoquin and desipramine hydroxylation in a Swedish population

1992 • 190 citations

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

1985 • 173 citations

Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in luman beings

1989 • 167 citations

Haloperidol Disposition Is Dependent on Debrisoquine Hydroxylation Phenotype

1992 • 157 citations

Bayesian Parameter Estimation and Population Pharmacokinetics

1992 • 137 citations

Genetically variable metabolism of antidepressants and neuroleptic drugs in man

1993 • 136 citations

Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes

1985 • 91 citations

Clinical pharmacokinetic studies of perphenazine.

1976 • 83 citations

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1984 • 82 citations

Debrisoquine oxidation phenotype during neuroleptic monotherapy

1991 • 66 citations

Disposition of the neuroleptic zuclopenthixol cosegregates with the polymorphic hydroxylation of debrisoquine in humans

1991 • 65 citations

The Use of Therapeutic Drug Monitoring Data to Document Kinetic Drug Interactions

1994 • 61 citations

Nonparametric Estimation of Population Characteristics of the Kinetics of Lithium from Observational and Experimental Data

1994 • 36 citations

CYP2D6 genotype determination in the Danish population

1994 • 36 citations

Population Pharmacokinetics of Gentamicin

1992 • 29 citations

A High-Performance Liquid Chromatographic Method for the Assay of Perphenazine and Its Dealkylated Metabolite in Serum After Therapeutic Doses

1983 • 24 citations