Proinsulin trafckin and processing in the pancreatic B cell

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

BIOSYNTHETIC PROTEIN TRANSPORT AND SORTING BY THE ENDOPLASMIC RETICULUM AND GOLGI

1987 • 985 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

Macro- and Micro-Domains in the Endocrine Pancreas

1982 • 306 citations

Living with Clathrin: Its Role in Intracellular Membrane Traffic

1988 • 304 citations

Vesicular transport between the endoplasmic reticulum and the Golgi stack requires the NEM-sensitive fusion protein

1989 • 288 citations

The trans-most cisternae of the Golgi complex: A compartment for sorting of secretory and plasma membrane proteins

1987 • 275 citations

Dissection of a single round of vesicular transport: Sequential intermediates for intercisternal movement in the Golgi stack

1989 • 269 citations

Role of zinc in insulin biosynthesis

1980 • 251 citations

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.

1987 • 204 citations

The insulin secretory granule

1989 • 188 citations

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose

1986 • 187 citations

The insulin factory: a tour of the plant surroundings and a visit to the assembly line

1985 • 172 citations

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content.

1980 • 168 citations

Molecular Sorting in the Secretory Pathway

1989 • 155 citations

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

1988 • 135 citations

The role of stress proteins in membrane biogenesis

1988 • 133 citations

Protein sorting among two distinct export pathways occurs from the content of maturing exocrine storage granules.

1987 • 119 citations

Regulation of Insulin-Gene Expression

1987 • 73 citations

Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.

1987 • 72 citations

Efficient targeting to storage granules of human proinsulins with altered propeptide domain.

1988 • 64 citations

Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells

1989 • 41 citations

Intracellular traffic of newly synthesized proteins. Current understanding and future prospects.

1989 • 35 citations

The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide

1988 • 23 citations

Chapter 6 Biosynthesis of Insulin and Glucagon

1981 • 19 citations