Aromatase inhibitors, their pharmacology and application

The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer¹¹

1977 • 369 citations

Studies on the Mechanism of Estrogen Biosynthesis. VIII. The Development of Inhibitors of the Enzyme System in Human Placenta1

1973 • 301 citations

Plasma Precursors of Estrogen. I. Extent of Conversion of Plasma Δ⁴-Androstenedione to Estrone in Normal Males and Nonpregnant Normal, Castrate and Adrenalectomized Females

1967 • 257 citations

Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo

1981 • 215 citations

A Randomized Trial Comparing Surgical Adrenalectomy with Aminoglutethimide plus Hydrocortisone in Women with Advanced Breast Cancer

1981 • 204 citations

Metabolic clearance and blood production rates of estrogens in postmenopausal women

1971 • 169 citations

Endocrine Consequences of Continuous Antiestrogen Therapy with Tamoxifen in Premenopausal Women

1979 • 144 citations

Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

1981 • 141 citations

10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

1981 • 127 citations

ŒSTRADIOL SYNTHESIS BY A HUMAN BREAST CARCINOMA

1974 • 119 citations

Suicide enzyme inhibitors as potential drugs

1981 • 119 citations

Studies on the mechanism of estrogen biosynthesis in the rat ovary–I

1976 • 113 citations

ENZYME-GENERATED INTERMEDIATES DERIVED FROM 4-ANDR0STENE-3,6,17-TRI0NE AND 1,4,6-ANDR0STATRIENE-3,17-DI0NE CAUSE A TIME-DEPENDENT DECREASE IN HUMAN PLACENTAL AROMATASE ACTIVITY

1981 • 104 citations

Geometric Isomers of Substituted Triphenylethylenes and Antiestrogen Action

1981 • 102 citations

Inhibition of Peripheral Aromatization by Aromatase Inhibitors, 4-Hydroxy- and 4-Acetoxy-Androstene-3,17 Dione*

1980 • 99 citations

Estrogen synthesis and estradiol binding by human mammary tumors.

1978 • 78 citations

Aromatase inhibitors—iv. Regression of hormone-dependent, mammary tumors in the rat with 4-acetoxy-4-androstene-3,17-dione

1979 • 70 citations

Aromatase enzyme catalysis is involved in the potent inhibition of estrogen biosynthesis caused by 4-acetoxy- and 4-hydroxy-4-androstene-3, 17-dione.

1982 • 67 citations

Effect of an aromatase inhibitor, 1,4,6-androstatriene-3,17-dione, on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in the rat and its mechanism of action in vivo

1982 • 40 citations

Norethisterone, a Major Ingredient of Contraceptive Pills, Is a Suicide Inhibitor of Estrogen Biosynthesis

1982 • 39 citations

Antifertility Effects of an Aromatase Inhibitor, 1,4,6-Androstatriene-3,17-Dione*

1979 • 36 citations

Metabolism of the aromatase inhibitor 4-hydroxy-4-androstene-3,17-dione by male rhesus monkeys

1981 • 30 citations

Estrogen synthesis and estradiol binding by human mammary tumors

1979 • 29 citations

Synthesis of deuterium- and tritium-labeled 4-hydroxyandrostene-3,17-dione, an aromatase inhibitor, and its metabolism in vitro and in vivo in the rat

1982 • 25 citations

Inhibition of Estrogen Biosynthesis and Regression of Mammary Tumors by Aromatase Inhibitors

1982 • 20 citations