Coordinate overproduction of orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in hamster cells resistant to pyrazofurin and 6-azauridine.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

TRANSITION STATE ANALOG INHIBITORS AND ENZYME CATALYSIS

1976 • 415 citations

Suicide enzyme inactivators

1976 • 366 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

8-AZAGUANINE RESISTANCE IN MAMMALIAN CELLS I. HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE

1972 • 273 citations

Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides.

1977 • 266 citations

Further Observations on the Chromosomes of Chinese Hamster Cells in Tissue Culture<xref ref-type="fn" rid="FN1">2</xref>

1959 • 265 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

N-(Phosphonacetyl)-l-Aspartate, a Potent Transition State Analog Inhibitor of Aspartate Transcarbamylase, Blocks Proliferation of Mammalian Cells in Culture

1974 • 217 citations

Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of the six biosynthetic enzymes

1973 • 205 citations

Orotidylic Acid Decarboxylase: Inhibition Studies with Azauridine 5′-Phosphate

1960 • 186 citations

Mechanisms of action of naturally occurring irreversible enzyme inhibitors

1975 • 144 citations

The Biochemical Activity of 6-Azauridine: Interference with Pyrimidine Metabolism in Transplantable Mouse Tumors

1959 • 136 citations

The cellular location of dihydroorotate dehydrogenase: Relation to de novo biosynthesis of pyrimidines

1976 • 135 citations

Uridine Kinase from Ehrlich Ascites Tumor: Purification and Properties

1960 • 129 citations

BIOCHEMISTRY AND BIOLOGICAL EFFECTS OF THE PYRAZOFURINS^* (PYRAZOMYCINS): INITIAL CLINICAL TRIAL

1975 • 106 citations

Studies on the coordinate activity and lability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration

1971 • 104 citations

Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.

1975 • 104 citations

Clinical, biological, and biochemical effect of pyrazofurin.

1978 • 103 citations

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.

1976 • 97 citations

N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis.

1979 • 95 citations

Possible Enzymic Mechanism for the Development of Resistance against Fluorouracil in Ascites Tumours

1959 • 92 citations

Purification and Kinetic Properties of Brain Orotidine 5′-Phosphate Decarboxylase

1968 • 87 citations

3-Ribosylpurines

1964 • 87 citations

Assay of ribonucleotide reduction in nucleotide-permeable hamster cells

1978 • 77 citations

Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.

1978 • 74 citations

Experimental Antitumor Activity of Pyrazomycin

1973 • 72 citations

Purification and Properties of Orotic Acid-decarboxylating Enzymes from Calf Thymus

1964 • 71 citations

Studies on the control of pyrimidine biosynthesis in human diploid cell strains, I. Effect of 6-azauridine on cellular phenotype.

1967 • 69 citations

Interconversion of different molecular weight forms of human erythrocyte orotidylate decarboxylase.

1975 • 59 citations

Orotic aciduria

1969 • 56 citations

Regulation of Uridylic Acid Biosynthesis in Eukaryotic Cells

1972 • 56 citations

Purification, size, and properties of the complex of orotate phosphoribosyltransferase: orotidylate decarboxylase from mouse Ehrlich ascites carcinoma.

1976 • 56 citations

Alterations in pyrimidine metabolism in L5178Y leukemia cells resistant to 6-azauridine.

1961 • 52 citations

Effect of allopurinol and its metabolic derivatives on the configuration of human orotate phosphoribosyltransferase and orotidine 5'-phosphate decarboxylase

1975 • 50 citations

Mechanism of allopurinol-mediated increase in enzyme activity in man

1972 • 47 citations

Inhibition of de novo pyrimidine nucleotide and DNA synthesis and growth of cultured Novikoff rat hepatoma cells and other cell lines by pyrazofurin (NSC 143095).

1976 • 38 citations

The transformation of BHK 21 hamster cells by simian virus 40

1972 • 37 citations

Subunit structure of the orotate phosphoribosyltransferase-orotidylate decarboxylase complex from human erythrocytes

1977 • 34 citations

Hereditary Orotic Aciduria: Evidence for a Structural Gene Mutation

1974 • 30 citations

Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro.

1977 • 28 citations

Oxipurinol and orotic aciduria: Effect on the orotidine-5′-monophosphate decarboxylase activity of cultured human fibroblasts

1974 • 17 citations

Concurrent development of resistance to 6‐azauridine and adenosine in a mouse cell line

1975 • 16 citations

The rapid separation of orotate, orotidylate, and uridylate by thin-layer chromatography

1977 • 14 citations

Increased intracellular phosphoribosylpyrophosphate and accelerated orotic acid decarboxylation in a mouse cell line resistant to purine and pyrimidine ribonucleosides

1977 • 7 citations