Regulation of purine biosynthesis and turnover

Methods of Enzymatic Analysis

1975 • 20,446 citations

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1967 • 1,210 citations

The Enzymes of Glutamine Metabolism

1974 • 458 citations

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Gout

1969 • 452 citations

The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme

1972 • 432 citations

Biochemical Bases of Accelerated Purine Biosynthesis de Novo in Human Fibroblasts Lacking Hypoxanthine-Guanine Phosphoribosyltransferase

1968 • 251 citations

The Regulation of Activity of Phosphoribosylpyrophosphate Amidotransferase by Purine Ribonucleotides: A Potential Feedback Control of Purine Biosynthesis

1959 • 250 citations

Phosphoribosylpyrophosphate in Man: Biochemical and Clinical Significance

1971 • 219 citations

The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O)

1976 • 214 citations

The Enzymology of Feedback Inhibition of Glutamine Phosphoribosylpyrophosphate Amidotransferase by Purine Ribonucleotides

1964 • 207 citations

Regulation of the synthesis of 5-phosphoribosyl-i-pyrophosphate in intact red blood cells and in cell-free preparations

1969 • 204 citations

The Regulation of Glutamine Synthesis in Microorganisms

1970 • 190 citations

Concentrations of free glucogenic amino acids in livers of rats subjected to various metabolic stresses

1967 • 187 citations

Glucose-6-phosphatase deficiency glycogen storage disease. Studies on the interrelationships of carbohydrate, lipid, and purine abnormalities.

1962 • 183 citations

Human Glutamine Phosphoribosylpyrophosphate Amidotransferase

1973 • 175 citations

Human Phosphoribosylpyrophosphate Synthetase

1972 • 163 citations

Synthesis of 5-Phosphoribosyl 1-Pyrophosphate from Glucose in Ehrlich Ascites Tumor Cells in Vitro

1965 • 157 citations

ENZYMES ESSENTIAL FOR THE BIOSYNTHESIS OF NUCLEIC ACID GUANINE; INOSINE 5′-PHOSPHATE DEHYDROGENASE OF AEROBACTER AEROGENES

1957 • 152 citations

Cumulative feedback inhibition in the multiple end product regulation of glutamine synthetase activity in Escherichiacoli

1964 • 147 citations

Guanosine 5'-Phosphate Reductase and Its Role in the Interconversion of Purine Nucleotides

1960 • 147 citations

The Mechanism of Amino Acid Control of Guanylate and Adenylate Biosynthesis

1971 • 134 citations

Human Glutamine Phosphoribosylpyrophosphate Amidotransferase

1973 • 133 citations

Purification and properties of 5-phosphoribosylpyrophosphate amidotransferase from adenocarcinoma 755 cells

1969 • 131 citations

Depletion of Erythrocyte Phosphoribosylpyrophosphate in Man

1970 • 129 citations

Synthesis of Essential Amino Acids from Their α-Keto Analogues by Perfused Rat Liver and Muscle

1973 • 128 citations

Regulation of Purine Ribonucleotide Synthesis by End Product Inhibition

1965 • 125 citations

Regulation and Mechanism of Phosphoribosylpyrophosphate Synthetase

1969 • 124 citations

EFFECTS OF FEEDING INDIVIDUAL AMINO ACIDS UPON THE DISTRIBUTION OF OTHER AMINO ACIDS BETWEEN CELLS AND EXTRACELLULAR FLUID

1948 • 118 citations

5-PHOSPHORIBOSYLAMINE, A PRECURSOR OF GLYCINAMIDE RIBOTIDE

1956 • 104 citations

Glutamine Phosphoribosylpyrophosphate Amidotransferase

1968 • 104 citations

The Interaction of 6-Diazo-5-oxo-l-norleucine with Phosphoribosyl Pyrophosphate Amidotransferase

1963 • 101 citations

Human erythrocyte phosphoribosylpyrophosphate synthetase mutationally altered in regulatory properties

1973 • 99 citations

The Mechanism of Dietary Alterations in Rat Hepatic Xanthine Oxidase Levels

1966 • 99 citations

Adenylate deaminase. I. The effects of adenosine and guanosine triphosphates on activity and the organ distribution of the regulated enzyme.

1966 • 98 citations

5'-Nucleotidase of Rat Liver Microsomes

1960 • 96 citations

Purine nucleotide synthesis in lymphoblasts cultured from normal subjects and a patient with Lesch-Nyhan syndrome

1973 • 93 citations

Regulation and Mechanism of Phosphoribosylpyrophosphate Synthetase

1971 • 90 citations

Regulation of purine biosynthesis in cultured human cells

1970 • 87 citations

Human Phosphoribosylpyrophosphate Synthetase: Increased Enzyme Specific Activity in a Family with Gout and Excessive Purine Synthesis

1973 • 86 citations

Phosphoribosyl Pyrophosphate Amidotransferase

1963 • 85 citations

Studies on the Mechanism of Regulation by Cortisone of the Metabolism of Liver Purine and Ribonucleic Acid

1963 • 85 citations

5′-nucleotidase of chicken liver

1967 • 84 citations

Properties of 5-Phosphoribosyl-1-pyrophosphate Amidotransferase from Human Lymphoblasts

1973 • 81 citations

Human IMP dehydrogenase

1974 • 79 citations

Formation of nucleotides of [6-14C]allopurinol and [6-14C]oxipurinol in rat tissues and effects on uridine nucleotide pools

1973 • 79 citations

Excessive production of uric acid in type I glycogen storage disease

1968 • 75 citations

Variations in purine metabolism of cultured skin fibroblasts from patients with gout

1968 • 74 citations

Liver nucleotide metabolism in relation to amino acid supply

1972 • 74 citations

Characterization of a Feedback-Resistant Phosphoribosylpyrophosphate Synthetase from Cultured, Mutagenized Hepatoma Cells That Overproduce Purines

1973 • 70 citations

Altered kinetic property of erythrocyte phosphoribosylpsyrophosphate synthetase in excessive purine production.

1972 • 69 citations

Effects of nicotinic acid on human fibroblast purine biosynthesis

1972 • 67 citations

The Inhibition of Succinoadenylate Kinosynthetase of Escherichia coli by Adenosine and Guanosine 5'-Monophosphates

1963 • 67 citations

Relationships between Hepatic Enzyme Induction, Glutamate Formation, and Purine Nucleotide Biosynthesis in Glucocorticoid Action

1966 • 64 citations

Glutathione Reductase in Red Blood Cells: Variant Associated with Gout

1967 • 59 citations

Human Adenylosuccinate Synthetase

1974 • 58 citations

INHIBITION OF INOSINE 5′-PHOSPHATE DEHYDROGENASE FROM EHRLICH ASCITES-TUMOUR CELLS BY 6-THIOINOSINE 5′-PHOSPHATE

1963 • 57 citations

5-Phosphoribosyl pyrophosphate synthetase from Ehrlich ascites tumor cells

1969 • 56 citations

Inosinic Acid Dehydrogenase of Sarcoma 180 Cells

1968 • 56 citations

Purification of Adenylosuccinate Synthetase from Rabbit Skeletal Muscle

1974 • 53 citations

Properties of 5'-Nucleotidase from Hepatic Tissue of Higher Animals*

1968 • 52 citations

Enzymatic Synthesis of 5′-Phosphoribosylamine from Ribose 5-Phosphate and Ammonia, an Alternate First Step in Purine Biosynthesis

1968 • 50 citations

De Novo purine biosynthesis by two pathways in Burkitt lymphoma cells and in human spleen

1972 • 50 citations

Effects of Hormones and Drugs on Phosphoribosyl Pyrophosphate Concentrations in Mouse Liver

1975 • 46 citations

Regulation of the biosynthesis of purine nucleotides in Schizosaccharomyces pombe. I. Properties of the phosphoribosylpyrophosphate: Glutamine amidotransferase of the wild strain and of a mutant desensitized towards feedback modifiers

1970 • 46 citations

Operation of pleiotropic control in hormonal regulation and in neoplasia

1974 • 46 citations

Phosphoribosylamidotransferase: Regulation of Activity in Virus-Induced Murine Leukemia by Purine Nucleotides

1967 • 37 citations

Comparison of Adaptations to Diet of Enzymes Involved in Uric Acid Production from IMP in Chickens and Rats

1974 • 37 citations

Imbalance of purine metabolism in hepatomas of different growth rates as expressed in behavior of glutamine-phosphoribosylpyrophosphate amidotransferase (amidophosphoribosyltransferase, EC 2.4.2.14).

1975 • 37 citations

Liver xanthine oxidase in gouty patients

1969 • 36 citations

Glutamine Phosphoribosylpyrophosphate Amidotransferase

1972 • 32 citations

Regulation of Purine and Pyrimidine Metabolism

1971 • 30 citations

Enzymatic Synthesis of Phosphoribosylamine in Human Cells

1974 • 27 citations

Sources of nitrogen as rate-limiting factors for purine biosynthesis de novo in Ehrlich ascites tumor cells

1969 • 27 citations

Kinetics of amidophosphoribosyltransferase in intact tumor cells

1974 • 26 citations

Concentration and synthesis of phosphoribosylpyrophosphate in erythrocytes from normal, hyperuricemic, and gouty subjects

1971 • 23 citations

The role of xanthine oxidase in hyperuricemic states

1974 • 22 citations

5-Phosphoribosyl pyrophosphate synthetase from ehrlich ascites-tumour cells: Effect of magnesium and ATP concentration on the enzymic activity

1967 • 21 citations

Regulation of the purine pathway in bakers yeast: Activity and feedback inhibition of phosphoribosyl-pyrophosphate amidotransferase

1971 • 20 citations

Ribonucleotides of Allopurinol and Oxipurinol in Rat Tissues and Their Significance in Purine Metabolism

1974 • 14 citations

Partial solubilization of protein and 5′-nucleotidase from microsomal membranes of the rat liver by ultrasonic irradiation

1968 • 14 citations

Pigeon liver amidophosphoribosyltransferase. Ligand-induced alterations in molecular and kinetic properties.

1976 • 12 citations

Purine base incorporation into erythrocyte nucleotides and erythrocyte phosphoribosyltransferase activity in primary gout.

1971 • 11 citations

Glutamine Synthesis in Rats with Diabetic Acidosis

1962 • 8 citations

Human phosphoribosylpyrophosphate synthetase: Increased enzyme specific activity in a family with gout and excessive purine synthesis

1973 • 8 citations