Human Alanyl-tRNA Synthetase: Conservation in Evolution of Catalytic Core and Microhelix Recognition

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

1990 • 1,345 citations

Domain structure of mitochondrial and chloroplast targeting peptides

1989 • 1,191 citations

Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA ^Gln and ATP at 2.8 Å Resolution

1989 • 888 citations

Single-stranded DNA ‘blue’ T7 promoter plasmids: a versatile tandem promoter system for cloning and protein engineering

1986 • 816 citations

Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA ^Asp

1991 • 635 citations

A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 Å

1990 • 620 citations

A simple structural feature is a major determinant of the identity of a transfer RNA

1988 • 596 citations

The 2.9 Å Crystal Structure of T. thermophilus Seryl-tRNA Synthetase Complexed with tRNA ^Ser

1994 • 452 citations

An operational RNA code for amino acids and possible relationship to genetic code.

1993 • 412 citations

The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

1987 • 367 citations

Aminoacylation of RNA minihelices with alanine

1989 • 327 citations

Yeast tRNAAsp recognition by its cognate class II aminoacyl-tRNA synthetase

1993 • 274 citations

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

1990 • 262 citations

The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction.

1994 • 253 citations

Structural and functional relationships between aminoacyl-tRNA synthetases

1992 • 225 citations

Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate

1972 • 170 citations

Crystal Structures at 2.5 Angstrom Resolution of Seryl-tRNA Synthetase Complexed with Two Analogs of Seryl Adenylate

1994 • 163 citations

An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription

1981 • 152 citations

Specificity for Aminoacylation of an RNA Helix: an Unpaired, Exocyclic Amino Group in the Minor Groove

1991 • 148 citations

Changing the Acceptor Identity of a Transfer RNA by Altering Nucleotides in a "Variable Pocket"

1988 • 132 citations

Primary Structure of a Large Aminoacyl-tRNA Synthetase

1981 • 130 citations

Overlapping Nucleotide Determinants for Specific Aminoacylation of RNA Microhelices

1992 • 115 citations

Functional contacts of a transfer RNA synthetase with 2′-hydroxyl groups in the RNA minor groove

1992 • 114 citations

Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation.

1994 • 111 citations

Purification and properties of alanine tRNA synthetase from Escherichia coli A tetramer of identical subunits.

1981 • 92 citations

Efficient aminoacylation of resected RNA helices by class II aspartyl-tRNA synthetase dependent on a single nucleotide.

1994 • 87 citations

Contributions of discrete tRNA^Serdomains to aminoacylation byE.coliseryl-tRNA synthetase: a kinetic analysis using model RNA substrates

1993 • 80 citations

Evidence for interaction of an aminoacyl transfer RNA synthetase with a region important for the identity of its cognate transfer RNA.

1988 • 80 citations

Enzymatic aminoacylation of sequence-specific RNA minihelices and hybrid duplexes with methionine.

1992 • 80 citations

Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase

1987 • 76 citations

Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo

1989 • 75 citations

A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA

1989 • 73 citations

Glycyl transfer ribonucleic acid synthetase from Escherichia coli. Purification, properties, and substrate binding

1974 • 72 citations

Enzymatic aminoacylation of single-stranded RNA with an RNA cofactor.

1991 • 69 citations

Evidence that the 3'-end of a transfer RNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase

1989 • 64 citations

Role of dimerization in yeast aspartyl-tRNA synthetase and importance of the class II invariant proline.

1993 • 55 citations

Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit.

1994 • 52 citations

RNA tetraloops as minimalist substrates for aminoacylation

1992 • 52 citations

Characterization of recA genes and recA mutants of Rhizobium meliloti and Rhizobium leguminosarum biovar viciae

1991 • 49 citations

Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity.

1985 • 46 citations

Acceptor Helix Interactions in a Class II tRNA Synthetase: Photoaffinity Crosslinking of an RNA Miniduplex Substrate

1994 • 41 citations

Amino Acid Replacements that Compensate for a Large Polypeptide Deletion in an Enzyme

1985 • 41 citations

Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases

1992 • 39 citations

Aminoacylation of RNA Minihelices: Implications for tRNA Synthetase Structural Design and Evolution

1993 • 37 citations

Dissection of a class II tRNA synthetase: Determinants for minihelix recognition are tightly associated with domain for amino acid activation

1993 • 33 citations

Glycyl- and alanyl-tRNA synthetases from Bombyx mori. Purification and properties.

1984 • 30 citations

Functional Dissection of a Predicted Class-Defining Motif in a Class II tRNA Synthetase of Unknown Structure

1994 • 27 citations

Idiographic representation of conserved domain of a class II tRNA synthetase of unknown structure

1993 • 26 citations

Primary structure of alanyl-tRNA synthetase and the regulation of its mRNA levels in Bombyx mori.

1990 • 26 citations

Molecular dissection of a transfer RNA and the basis for its identity

1989 • 26 citations

Tripartite functional assembly of a large class I aminoacyl tRNA synthetase

1992 • 21 citations

Region of a Conserved Sequence Motif in a Class II tRNA Synthetase Needed for Transfer of an Activated Amino Acid to an RNA Substrate

1994 • 16 citations

Purification and Properties of Alanyl-tRNA Synthetase from Bombyx mori: A Monomeric Enzyme1

1984 • 12 citations

Alanyl‐tRNA synthetase from Escherichia coli, Bombyx mori and Ratus ratus

1991 • 9 citations