Differential Regulation of theCYP11A1(P450scc) and Ferredoxin Genes in Adrenal and Placental Cells

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Molecular Biology of Steroid Hormone Synthesis*

1988 • 1,387 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

Promoter-specific activation of RNA polymerase II transcription by Sp1

1986 • 1,054 citations

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.

1992 • 635 citations

A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s.

1992 • 536 citations

Regulation of the Synthesis of Steroidogenic Enzymes in Adrenal Cortical Cells by ACTH

1988 • 488 citations

Isolation of Hormone-Producing Clonal Lines of Human Choriocarcinoma¹

1971 • 384 citations

Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I

1992 • 375 citations

Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.

1986 • 359 citations

Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP.

1987 • 328 citations

OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts

1987 • 255 citations

Hormonal Regulation of P450scc (20,22-desmolase) and P450cl7 (17α-hydroxylase/17,20-lyase) in Cultured Human Granulosa Cells*

1986 • 249 citations

Endocrine Physiology of the Placenta

1981 • 233 citations

Transcriptional regulation of steroid hydroxylase genes by corticotropin.

1986 • 219 citations

Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells.

1988 • 143 citations

Hormonal Regulation of Cytochrome P450 Enzymes, Cholesterol Side-Chain Cleavage and 17α-Hydroxylase/C17 – 20 Lyase in Leydig Cells1

1990 • 134 citations

[52] Adrenocortical Y1 cells

1979 • 115 citations

Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 by adrenocorticotropin in cultured bovine adrenocortical cells.

1981 • 111 citations

Human P450scc Gene Transcription Is Induced by Cyclic AMP and Repressed by 12-O-Tetradecanoylphorbol-13-Acetate and A23187 through Independent cis Elements

1990 • 109 citations

Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression.

1990 • 107 citations

Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme.

1990 • 107 citations

Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitro.

1990 • 99 citations

Human adrenodoxin reductase: two mRNAs encoded by a single gene on chromosome 17cen----q25 are expressed in steroidogenic tissues.

1988 • 98 citations

Induction of synthesis of mitochondrial steroidogenic enzymes of bovine adrenocortical cells by analogs of cyclic AMP.

1984 • 94 citations

cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.

1989 • 90 citations

Distinctive properties of adrenal cortex mitochondria

1990 • 84 citations

Novel cAMP Regulatory Elements in the Promoter Region of Bovine P-450(11β) Gene11

1990 • 82 citations

Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells

1990 • 82 citations

Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein

1991 • 67 citations

Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3',5'-monophosphate response element in the human gene for P450scc.

1992 • 66 citations

cAMP post-transcriptionally diminishes the abundance of adrenodoxin reductase mRNA.

1992 • 62 citations

Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.

1990 • 62 citations

Cloning and Structure of the Human Adrenodoxin Gene

1988 • 56 citations

Human chorionic gonadotropin and 8-bromo cyclic adenosine monophosphate promote an acute increase in cytochrome P450scc and adrenodoxin messenger RNAs in cultured human granulosa cells by a cycloheximide-insensitive mechanism.

1987 • 53 citations

Structures of regulatory regions in the human cytochrome P-450scc (desmolase) gene

1991 • 50 citations

Synthesis of the Cholesterol Side-Chain Cleavage Enzymes in Cultured Rat Ovarian Granulosa Cells: Induction by Follicle-Stimulating Hormone and Dibutyryl Adenosine 3′,5′-Monophosphate*

1986 • 49 citations

The 5′‐flanking region of the human P‐450(SCC) gene shows responsiveness to CAMP‐dependent regulation in a transient gene‐expression system of Y‐1 adrenal tumor cells

1988 • 49 citations

cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3',5'-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells

1993 • 48 citations

Adrenodoxin biosynthesis by bovine adrenal cells in monolayer culture. Induction by adrenocorticotropin.

1982 • 43 citations

Glucocorticoid and Cyclic Adenosine 3′5′-Monophosphate-Mediated Induction of Cholesterol Side-Chain Cleavage Cytochrome P450 (P450SCc) in MA-10 Tumor Leydig Cells. Increases in mRNA Are Cycloheximide Sensitive*

1990 • 36 citations

Regulation of steroidogenesis in rat leydig cells in culture: Effect of human chorionic gonadotropin and dibutyryl cyclic AMP on the synthesis of cholesterol side chain cleavage cytochrome P-450 and adrenodoxin

1985 • 36 citations

Regulation of mRNAs for Human Steroidogenic Enzymes

1989 • 28 citations

3',5'-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1

1992 • 27 citations

The 5′-region of the P450XIA1 (P450scc) gene contains a basal promoter and an adrenal-specific activating domain

1989 • 25 citations

Identification of positive and negative placenta-specific basal elements and a cyclic adenosine 3',5'-monophosphate response element in the human gene for P450scc

1992 • 25 citations

Two promoters in the bovine adrenodoxin gene and the role of associated, unique cAMP-responsive sequences

1992 • 22 citations

Transcription of the human ferredoxin gene through a single promoter which contains the 3',5'-cyclic adenosine monophosphate-responsive sequence and Sp 1-binding site

1992 • 15 citations

Basal transcriptional activity and cyclic adenosine 3',5'-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells

1993 • 14 citations

Studies on the Structure of Genes Expressed during Development

1978 • 13 citations

Regulation of human cytochrome P450scc and adrenodoxin messenger ribonucleic acids in JEG-3 cytotrophoblast cells

1992 • 12 citations

Analysis of the human adrenodoxin promoter: Evidence for its activity

1989 • 8 citations

Induction of rat granulosa cell steroidogenic enzyme activities and their messenger ribonucleic acids by a splenocyte-derived factor

1994 • 2 citations