Driving earlier clinical attrition: if you want to find the needle, burn down the haystack. Considerations for biomarker development

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2001 • 6,216 citations

The price of innovation: new estimates of drug development costs

2003 • 4,276 citations

Can the pharmaceutical industry reduce attrition rates?

2004 • 3,946 citations

Risks in new drug development: Approval success rates for investigational drugs

2001 • 457 citations

The Value of Improving the Productivity of the Drug Development Process

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Acute Effects of Lamotrigine (BW430C) in Persons With Epilepsy

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Arousal-enhancing properties of the CB1 cannabinoid receptor antagonist SR 141716A in rats as assessed by electroencephalographic spectral and sleep-waking cycle analysis

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Original Articles Sibutramine Reduces Food Intake in Non‐Dieting Women with Obesity

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Comparison of the effects of sibutramine and other monoamine reuptake inhibitors on food intake in the rat

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Measurement Validity in Physical Therapy Research

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Keynote review: Is declining innovation in the pharmaceutical industry a myth?

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The contribution of clinical pharmacology surrogates and models to drug development—a critical appraisal

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