RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1999 • 6,580 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

Oncogenic kinase signalling

2001 • 3,632 citations

Expression profiling reveals off-target gene regulation by RNAi

2003 • 2,294 citations

PI3K/Akt signalling pathway and cancer

2003 • 2,157 citations

Protein kinases — the major drug targets of the twenty-first century?

2002 • 2,101 citations

Targeting the PI3K-Akt pathway in human cancer

2003 • 1,262 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

Analysis of gene function in somatic mammalian cells using small interfering RNAs

2002 • 1,108 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

Structure, regulation and function of PKB/AKT—a major therapeutic target

2003 • 695 citations

BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571

2002 • 675 citations

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

2004 • 600 citations

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance

2005 • 537 citations

Issues and progress with protein kinase inhibitors for cancer treatment

2003 • 529 citations

A Phospholipase C-Dependent Inositol Polyphosphate Kinase Pathway Required for Efficient Messenger RNA Export

1999 • 524 citations

Smart drugs: Tyrosine kinase inhibitors in cancer therapy

2002 • 510 citations

Specificity of short interfering RNA determined through gene expression signatures

2003 • 497 citations

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

2004 • 485 citations

A Multitargeted, Metronomic, and Maximum-Tolerated Dose “Chemo-Switch” Regimen is Antiangiogenic, Producing Objective Responses and Survival Benefit in a Mouse Model of Cancer

2004 • 479 citations

Noise amidst the silence: off-target effects of siRNAs?

2004 • 360 citations

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

2003 • 343 citations

Strategies to overcome resistance to targeted protein kinase inhibitors

2004 • 332 citations

The art and design of genetic screens: yeast

2001 • 272 citations

Perspectives on the development of a molecularly targeted agent

2002 • 267 citations

p38 Kinase-dependent MAPKAPK-2 Activation Functions as 3-Phosphoinositide-dependent Kinase-2 for Akt in Human Neutrophils

2001 • 265 citations

Binding of Inositol Phosphate to DNA-PK and Stimulation of Double-Strand Break Repair

2000 • 256 citations

The Akt Pathway: Molecular Targets for Anti-Cancer Drug Development

2004 • 250 citations

A Bcr/Abl-independent, Lyn-dependent Form of Imatinib Mesylate (STI-571) Resistance Is Associated with Altered Expression of Bcl-2

2004 • 242 citations

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

2004 • 226 citations

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

2005 • 219 citations

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

2004 • 175 citations

How versatile are inositol phosphate kinases?

2004 • 173 citations

Targeting protein kinases

2004 • 116 citations

The Casein Kinase I Family in Wnt Signaling

2001 • 111 citations

Casein Kinase Iγ Subfamily.

1995 • 106 citations

Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK

2002 • 102 citations

Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway

2004 • 95 citations

Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase

2004 • 87 citations

The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization

2002 • 87 citations

Binding of Inositol Hexakisphosphate (IP6) to Ku but Not to DNA-PKcs

2002 • 83 citations

The Pathway for the Production of Inositol Hexakisphosphate in Human Cells

2004 • 77 citations

The Human Homolog of the Rat Inositol Phosphate Multikinase Is an Inositol 1,3,4,6-Tetrakisphosphate 5-Kinase

2002 • 72 citations

Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6‐pentakisphosphate 3‐phosphatase activity

2001 • 47 citations

SRCircumventing imatinib resistance

2004 • 30 citations

The ProbeLibrary™-Expression profiling 99% of all human genes using only 90 dual-labeled real-time PCR Probes

2004 • 18 citations

Cloning and chromosome mapping of the human casein kinase I γ3 gene (CSNK1G3)

1998 • 6 citations