The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex.

1991 • 628 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs

1990 • 479 citations

Vaccine design : the subunit and adjuvant approach

1995 • 449 citations

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

1995 • 341 citations

Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.

1994 • 315 citations

Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.

1996 • 313 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

1993 • 292 citations

Interleukin‐12 production by human polymorphonuclear leukocytes

1995 • 285 citations

Monophosphoryl lipid A as an adjuvant. Past experiences and new directions.

1995 • 283 citations

Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon

1994 • 223 citations

Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells

1995 • 168 citations

Structural and Immunological Characterization of the Vaccine Adjuvant QS-21

1995 • 139 citations

Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells

1996 • 135 citations

Lipopolysaccharide and monophosphoryl lipid A differentially regulate interleukin-12, gamma interferon, and interleukin-10 mRNA production in murine macrophages

1997 • 132 citations

Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.

1995 • 121 citations

Beneficial modification of the endotoxin molecule.

1984 • 105 citations

The Control of the Antibody Isotype Response to Recombinant Human Immunodeficiency Virus gp120 Antigen by Adjuvants

1992 • 83 citations

Establishment of Lipopolysaccharide-dependent Nuclear Factor κB Activation in a Cell-free System

1995 • 81 citations

A clinically relevant HIV-1 subunit vaccine protects rhesus macaques from in vivo passaged simian–human immunodeficiency virus infection

1998 • 76 citations

Cytokine cross‐talk between phagocytic cells and lymphocytes: Relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity

1993 • 72 citations

Accessory Cell Requirements for Saponin Adjuvant-Induced Class I MHC Antigen-Restricted Cytotoxic T-Lymphocytes

1994 • 38 citations

Immunogenicity and Toxicity Testing of an Experimental HIV-1 Vaccine in Nonhuman Primates

1992 • 36 citations

A rationale for the prophylactic use of monophosphoryl lipid A in sepsis and septic shock

1992 • 24 citations

Studies on the Cellular Site of Action of the Adjuvant Activity of Saponin for Sheep Erythrocytes

1982 • 23 citations

Induction and Detection of T-Cell Responses

2003 • 12 citations