Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

Membrane curvature and mechanisms of dynamic cell membrane remodelling

2005 • 2,031 citations

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System

2000 • 1,628 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

Amyloid pores from pathogenic mutations

2002 • 1,260 citations

Biomembranes: molecular structure and function

1989 • 1,257 citations

How proteins produce cellular membrane curvature

2005 • 1,223 citations

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

2010 • 953 citations

Structure and Dynamics of Micelle-bound Human α-Synuclein

2004 • 884 citations

Permeabilization of Lipid Bilayers Is a Common Conformation-dependent Activity of Soluble Amyloid Oligomers in Protein Misfolding Diseases

2004 • 883 citations

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

1992 • 852 citations

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.

2000 • 830 citations

Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein

2002 • 817 citations

α-Synuclein, Especially the Parkinson's Disease-associated Mutants, Forms Pore-like Annular and Tubular Protofibrils

2002 • 795 citations

Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology

2003 • 790 citations

Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons

2000 • 724 citations

Parkinson's Disease α-Synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death

2006 • 648 citations

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

2001 • 589 citations

Mechanism of endophilin N-BAR domain-mediated membrane curvature

2006 • 582 citations

The BAR Domain Superfamily: Membrane-Molding Macromolecules

2009 • 566 citations

Amphipathic helices and membrane curvature

2009 • 538 citations

Structure of membrane-bound α-synuclein from site-directed spin labeling and computational refinement

2008 • 474 citations

Biophysical Properties of the Synucleins and Their Propensities to Fibrillate

2002 • 456 citations

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

2003 • 427 citations

Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence

2009 • 389 citations

How curved membranes recruit amphipathic helices and protein anchoring motifs

2009 • 385 citations

The Hydrophobic Insertion Mechanism of Membrane Curvature Generation by Proteins

2008 • 382 citations

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

2009 • 357 citations

Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores

1994 • 349 citations

Structure of membrane-bound α-synuclein studied by site-directed spin labeling

2004 • 343 citations

The eloquent ape: genes, brains and the evolution of language

2005 • 337 citations

Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling

2003 • 325 citations

Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP111-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

2003 • 291 citations

Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms

2006 • 276 citations

Golgi Fragmentation Occurs in the Cells with Prefibrillar α-Synuclein Aggregates and Precedes the Formation of Fibrillar Inclusion

2002 • 273 citations

In Situ and in Vitro Study of Colocalization and Segregation of α-Synuclein, Ubiquitin, and Lipids in Lewy Bodies

2000 • 264 citations

Islet amyloid polypeptide‐induced membrane leakage involves uptake of lipids by forming amyloid fibers

2004 • 261 citations

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

2008 • 261 citations

Amphipathic motifs in BAR domains are essential for membrane curvature sensing

2009 • 246 citations

Quantification of α-Synuclein Binding to Lipid Vesicles Using Fluorescence Correlation Spectroscopy

2006 • 243 citations

Structural models of human apolipoprotein A-I: a critical analysis and review

2001 • 235 citations

Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons

1997 • 234 citations

Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro

2003 • 233 citations

α-Synuclein Has a High Affinity for Packing Defects in a Bilayer Membrane

2004 • 232 citations

Vesicle-micelle transition of phosphatidylcholine and octyl glucoside elucidated by cryo-transmission electron microscopy

1989 • 229 citations

Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations

2006 • 228 citations

Soluble Amyloid Oligomers Increase Bilayer Conductance by Altering Dielectric Structure

2006 • 223 citations

Structure and evolution of the apolipoprotein multigene family

1986 • 214 citations

Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

2003 • 209 citations

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix

2009 • 208 citations

Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson’s disease

2002 • 203 citations

Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes

2008 • 197 citations

The Structure of Apolipoprotein A-I in High Density Lipoproteins

2007 • 196 citations

α-Synuclein: Normal Function and Role in Neurodegenerative Diseases

2004 • 195 citations

Aβ42-Peptide Assembly on Lipid Bilayers

2002 • 184 citations

Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

2007 • 174 citations

α‐Synuclein and Polyunsaturated Fatty Acids Promote Clathrin‐Mediated Endocytosis and Synaptic Vesicle Recycling

2008 • 153 citations

Structural insights on physiological functions and pathological effects of ±‐synuclein

2008 • 134 citations

Amphipathic helixes and plasma lipoproteins: Thermodynamic and geometric considerations

1977 • 122 citations

Physiological and pathological properties of α-synuclein

2007 • 116 citations

Fragmentation of Golgi apparatus of nigral neurons with α-synuclein-positive inclusions in patients with Parkinson’s disease

2006 • 113 citations

Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic alpha helixes control membrane stability.

1993 • 106 citations

Mechanistic aspects of Parkinson’s disease: α-synuclein and the biomembrane

2007 • 99 citations

Systematic multiscale simulation of membrane protein systems

2009 • 96 citations

Membrane Remodeling from N-BAR Domain Interactions: Insights from Multi-Scale Simulation

2007 • 94 citations

Inter-Helix Distances in Lysophospholipid Micelle-Bound α-Synuclein from Pulsed ESR Measurements

2006 • 89 citations

New Insights into BAR Domain-Induced Membrane Remodeling

2009 • 80 citations

Biomembranes (molecular structure and function)

1989 • 80 citations

The role of α-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response

2008 • 74 citations

Studies of Synthetic Peptides of Human Apolipoprotein A-I Containing Tandem Amphipathic α-Helixes

1998 • 72 citations

Roles of Amphipathic Helices and the Bin/Amphiphysin/Rvs (BAR) Domain of Endophilin in Membrane Curvature Generation

2010 • 72 citations

Quantification of nano-scale intermembrane contact areas by using fluorescence resonance energy transfer

2009 • 64 citations

Electron Paramagnetic Resonance Spectroscopy of Site-directed Spin Labels Reveals the Structural Heterogeneity in the N-terminal Domain of ApoA-I in Solution

2007 • 63 citations

Alpha-Synuclein is localized in a subpopulation of rat brain synaptic vesicles

2008 • 61 citations

Membrane Binding by the Endophilin N-BAR Domain

2009 • 58 citations

Secondary structure and dynamics of micelle bound β‐ and γ‐synuclein

2006 • 51 citations

A Stable Lipid-Induced Aggregate of α-Synuclein

2010 • 43 citations

Effect of the Arrangement of Tandem Repeating Units of Class A Amphipathic α-Helixes on Lipid Interaction

1995 • 32 citations

The effects of α-synuclein on phospholipid vesicle integrity: a study using³¹P NMR and electron microscopy

2008 • 25 citations