Deregulated degradation of the cdk inhibitor p27 and malignant transformation

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

1996 • 1,583 citations

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

1999 • 1,521 citations

A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 -Deficient Mice

1996 • 1,488 citations

Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

1996 • 1,283 citations

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

1997 • 1,055 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex

1996 • 889 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1998 • 796 citations

p27Kip1 ubiquitination and degradation is regulated by the SCFSkp2 complex through phosphorylated Thr187 in p27

1999 • 787 citations

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

2000 • 704 citations

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

1999 • 702 citations

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

1997 • 698 citations

Regulation of the Cdk inhibitor p27 and its deregulation in cancer

2000 • 680 citations

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

1999 • 624 citations

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

1999 • 593 citations

Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β

1993 • 578 citations

Skp2 is oncogenic and overexpressed in human cancers

2001 • 498 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

The cell-cycle regulatory protein Cks1 is required for SCFSkp2-mediated ubiquitinylation of p27

2001 • 467 citations

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.

1997 • 428 citations

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 ^CIP1/WAF1 and cyclin D proteins

1998 • 401 citations

A CDK-Independent Function of Mammalian Cks1

2001 • 356 citations

Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization

2002 • 348 citations

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.

1995 • 338 citations

A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.

1994 • 332 citations

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

1995 • 327 citations

p27Kip1: Regulation and Function of a Haploinsufficient Tumor Suppressor and Its Misregulation in Cancer

2001 • 295 citations

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

2001 • 291 citations

A cell cycle-regulated inhibitor of cyclin-dependent kinases.

1994 • 285 citations

Role of the F-box protein Skp2 in lymphomagenesis

2001 • 283 citations

A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression

2002 • 281 citations

Phosphorylation of p27 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export

2002 • 267 citations

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma.

1998 • 263 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 258 citations

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

2001 • 254 citations

Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma

2000 • 225 citations

Mammalian G1 cyclins

1994 • 219 citations

Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis.

2002 • 217 citations

Degradation of p27 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway

2001 • 210 citations

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

1995 • 207 citations

Novel p27^kip1 C-Terminal Scatter Domain Mediates Rac-Dependent Cell Migration Independent of Cell Cycle Arrest Functions

2002 • 206 citations

NADP‐malic enzyme from plants: a ubiquitous enzyme involved in different metabolic pathways

2001 • 203 citations

Localization and expression of p27KIP1 in multistage colorectal carcinogenesis.

1998 • 201 citations

Inverse relation between levels of p27Kip1 and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

2001 • 182 citations

p27/Kip1 mutation found in breast cancer.

1996 • 174 citations

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

2000 • 169 citations

Cell-Free Degradation of p27^kip1, a G₁ Cyclin-Dependent Kinase Inhibitor, Is Dependent on CDK2 Activity and the Proteasome

1999 • 166 citations

High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas.

2001 • 152 citations

p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice

1999 • 145 citations

Role of the F-Box Protein Skp2 in Adhesion-Dependent Cell Cycle Progression

2001 • 137 citations

A Novel Target Gene, SKP2, within the 5p13 Amplicon That Is Frequently Detected in Small Cell Lung Cancers

2002 • 136 citations

Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours

1998 • 132 citations

Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells

1999 • 125 citations

Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

1998 • 123 citations

Regulation of the G1 to S transition by the ubiquitin pathway

2001 • 120 citations

ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but Impaired in p27-Null Cells

2002 • 119 citations

S-Phase Kinase-Associated Protein 2 Expression in Non-Hodgkin's Lymphoma Inversely Correlates with p27 Expression and Defines Cells in S Phase

2002 • 115 citations

The dynamics of cyclin dependent kinase structure

1996 • 101 citations

Role of p27Kip1 and Cyclin-Dependent Kinase 2 in the Proliferation of Non-Small Cell Lung Cancer

1998 • 97 citations

Proteasome-dependent Degradation of p27/kip1 in Gliomas

1999 • 85 citations

Regulation of Cyclin A-Cdk2 by SCF Component Skp1 and F-Box Protein Skp2

1999 • 78 citations

Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2

2001 • 54 citations

Degradation of p27kip1 at the G0-G1 transition mediated by a Skp2-independent ubiquitination pathway

2004 • 42 citations

p27 destruction: Cks1 pulls the trigger

2001 • 34 citations

Involvement of p27(KIP1) degradation by Skp2 in the regulation of proliferation in response to wounding of corneal epithelium.

2002 • 27 citations