Mechanisms of fever

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

1972 • 773 citations

Inhibitors of Ribosome Functions

1971 • 672 citations

Thermoreception and temperature regulation

1991 • 655 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds

1981 • 477 citations

Fever and Survival

1975 • 476 citations

Export-Mediated Assembly of Mycobacterial Glycoproteins Parallels Eukaryotic Pathways

2005 • 462 citations

The adverse effect of iron repletion on the course of certain infections.

1978 • 456 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Evidence for central timing of rhythmical mastication

1971 • 428 citations

Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation

1964 • 407 citations

Pathogenesis of Fever

1960 • 390 citations

Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits

1971 • 358 citations

Inhibitors of Protein Biosynthesis

1967 • 291 citations

Neural processes in thermoregulation.

1973 • 286 citations

Temperature regulation: The spinal cord as a site of extrahypothalamic thermoregulatory functions

2005 • 279 citations

The Pharmacology of Thermoregulation

1973 • 273 citations

Transport of proteins across normal cerebral arterioles

1973 • 267 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1953 • 265 citations

Fever and Reduced Iron: Their Interaction as a Host Defense Response to Bacterial Infection

1979 • 261 citations

A physiological criterion for setting thermal environmental limits for everyday work

1963 • 258 citations

Molecular basis of fever in humans

1982 • 252 citations

Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep.

1979 • 250 citations

DEMONSTRATION AND CHARACTERIZATION OF TWO DISTINCT HUMAN LEUKOCYTIC PYROGENS

1974 • 219 citations

Heat stroke: a review.

1976 • 208 citations

Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.

1978 • 206 citations

Survival value of fever in fish

1977 • 204 citations

Pyrogen fever and prostaglandin‐like activity in cerebrospinal fluid

1973 • 204 citations

Changes in body temperature after administration of amino acids, peptides, dopamine, neuroleptics and related agents

1979 • 198 citations

Fever: Pathogenesis, Pathophysiology, and Purpose

1979 • 195 citations

Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase

1978 • 193 citations

Recent studies of hypothalamic function

1976 • 184 citations

Prostaglandin E₁ fever induced in rabbits

1973 • 184 citations

Fever: Effect of Drug-Induced Antipyresis on Survival

1976 • 179 citations

Observations on the site and mode of action of pyrogens in the rabbit brain

1967 • 179 citations

THE PROPERTIES AND BIOLOGIC EFFECTS OF BACTERIAL PYROGENS

1950 • 179 citations

Fever, Its Biology, Evolution, and Function

1980 • 175 citations

Monoamines, pyrogens and cations: their actions on central control of bodytemperature.

1974 • 174 citations

Thermoregulatory mechanisms and their therapeutic implications

1980 • 173 citations

Changes in body temperature after administration of acetylcholine, histamine, morphine, prostaglandins and related agents

1980 • 167 citations

Effect of pyrogen and antipyretics on prostaglandin activity in cisternal c.s.f. of unanaesthetized cats

1973 • 166 citations

Changes in body temperature after administration of adrenergic and serotonergic agents and related drugs including antidepressants

1980 • 164 citations

Fever: Its Biology, Evolution, and Function

2015 • 163 citations

Temperature-elevating effect of a substance obtained from polymorphonuclear leucocytes.

1948 • 154 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1955 • 145 citations

Ability of Human Leukocytic Pyrogen to Stimulate Brain Prostaglandin Synthesis In Vitro

1982 • 135 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1953 • 131 citations

Prostaglandin E levels in third ventricular cerebrospinal fluid of rabbits during fever and changes in body temperature

1980 • 128 citations

Fever and survival in rabbits infected with Pasteurella multocida

1978 • 124 citations

Thermoregulation in rest and exercise.

1969 • 122 citations

Effect of temperature and pyrogens on single-unit activity in the rabbit's brain stem.

1968 • 112 citations

Specific responses of rat raphé neurones to skin temperature.

1977 • 112 citations

Temperature-sensitive neurons in preoptic-anterior hypothalamic region: actions of pyrogen and acetylsalicylate

1968 • 110 citations

Fever versus hyperthermia.

1979 • 107 citations

RELEASE OF AN ENDOGENOUS PYROGEN IN VITRO FROM RABBIT MONONUCLEAR CELLS

1967 • 105 citations

Microbial Iron Metabolism: A Comprehensive Treatise

1974 • 103 citations

Pyrogen-induced changes in the thermosensitivity of septal and preoptic neurons

1969 • 103 citations

Behavioral Fever in Newborn Rabbits

1976 • 100 citations

Antipyresis following perfusion of brain sites with vasopressin

1979 • 100 citations

On the Temperature in Diseases: A Manual of Medical Thermometry

2010 • 96 citations

An extensive exploration of the rat brain for sites mediating prostaglandin-induced hyperthermia

1977 • 93 citations

Antipyresis: Its effect on mortality rate of bacterially infected rabbits

1980 • 92 citations

Bactericidal and Metabolic Properties of Human Eosinophils

1972 • 90 citations

STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES

1958 • 88 citations

Prostaglandins and Related Compounds

1978 • 86 citations

Failure of rabbit neutrophils to secrete endogenous pyrogen when stimulated with staphylococci.

1980 • 85 citations

Biologically Active Endotoxins from Salmonella Mutants Deficient in O- and R-Polysaccharides and Heptose

1967 • 83 citations

Fever produced by microinjection of typhoid vaccine into hypothalamus of cats

1965 • 82 citations

Thermoregulation during fever: Change of set-point or change of gain

1970 • 81 citations

Comparison of Leukocytic Pyrogen and Leukocytic Endogenous Mediator

1977 • 81 citations

Central nervous system sites of action of a purified leucocyte pyrogen

1971 • 80 citations

Fever in Ectotherms: Evolutionary Implications

1979 • 80 citations

Further studies on the role of prostaglandin in fever

1974 • 79 citations

STUDIES ON THE MECHANISM OF ENDOGENOUS PYROGEN PRODUCTION

1974 • 79 citations

A hypothalamic region responsive to localized injection of pyrogens.

1967 • 77 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1967 • 74 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1959 • 72 citations

Fever response in the guinea pig before and after parturition

1981 • 71 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1962 • 70 citations

STUDIES ON THE ORIGIN OF HUMAN LEUKOCYTIC PYROGEN

1970 • 70 citations

Thermo-sensitive neurons in hypothalamic tissue slices in vitro

1980 • 69 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1964 • 67 citations

Reactivity pattern of vasopressin-containing neurons and its relation to the antipyretic reaction in the pregnant guinea pig

1980 • 67 citations

The Production of Antibody against Human Leukocytic Pyrogen

1977 • 66 citations

Modern views on the pathogenesis of fever and the mode of action of antipyretic drugs

1976 • 66 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1963 • 66 citations

Effect of calcium removal on thermosensitivity of preoptic neurons in hypothalamic slices

1980 • 65 citations

Further purification of rabbit leukocyte pyrogen.

1974 • 65 citations

Possible Relation between the Degree of Cardiac Adrenergic Innervation and the Resistance to Hypothermic Ventricular Fibrillation in Young Cats

1969 • 65 citations

Evidence that brain prostaglandin synthesis is not essential in fever.

1976 • 65 citations

Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

1973 • 65 citations

A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.

1975 • 63 citations

Behavioural and autonomic induction of prostaglandin E‐1 fever in squirrel monkeys.

1975 • 63 citations

Maternal and Fetal Arginine Vasopressin in the Chronically Catheterised Sheep

1974 • 61 citations

The Regulation of Body Temperature During Fever

1965 • 61 citations

Vasopressin may mediate febrile convulsions

1981 • 61 citations

TEMPERATURE REGULATION DURING FEVER IN MAN.

1964 • 61 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1958 • 61 citations

Prostaglandins of the E and F series in rabbit cerebrospinal fluid during fever induced by Newcastle disease virus,E. coli-endotoxin, or endogenous Pyrogen

1974 • 55 citations

Pyrogenicity of granulocyte lysosomes

1966 • 55 citations

Responses of antidromically identified preoptic neurons in the rat to neurotransmitters and to estrogen

1974 • 54 citations

The pathogenesis of fever

1955 • 53 citations

The effects of nucleus raphe magnus lesions on an ascending thermal pathway in the rat.

1982 • 52 citations

Mechanism of fever induction in rabbits

1976 • 51 citations

Production of endogenous pyrogen.

1979 • 50 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1958 • 50 citations

STUDIES ON THE MECHANISM OF FEVER ACCOMPANYING DELAYED HYPERSENSITIVITY

1972 • 50 citations

Persistence of febrile response to pyrogens after PO/AH lesions in squirrel monkeys

1976 • 50 citations

Leukocytic pyrogen and sodium acetylsalicylate on hypothalamic neurons in the cat

1975 • 49 citations

The Pyrogenicity of Bacterial Contaminants Found in Biologic Products

1945 • 48 citations

Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits.

1977 • 47 citations

Brain dysfunction in infantile febrile convulsions

1976 • 45 citations

Factors affecting the quantitative production and assay of human leukocytic pyrogen.

1970 • 45 citations

Pyrogen from Mouse Macrophages Causes Fever in Mice

1976 • 44 citations

Influence of sex and age on febrile responses to peripheral and central administration of pyrogens in the rabbit

1979 • 44 citations

Clinical fever: its history, manifestations and pathogenesis.

1979 • 43 citations

SYNTHESIS OF ENDOGENOUS PYROGEN BY RABBIT LEUKOCYTES

1973 • 43 citations

The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.

1977 • 43 citations

STUDIES ON NATURAL IMMUNITY TO PNEUMOCOCCUS TYPE III

1936 • 42 citations

Properties of human endogenous pyrogen.

1957 • 42 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1968 • 41 citations

Changes in body temperature produced by injecting prostaglandin E1, EGTA and bacterial endotoxins into the PO/AH region and the medulla oblongata of the rat

1973 • 41 citations

Microelectrophoresis of PGE1 onto single units in the rabbit hypothalamus

1975 • 41 citations

Cardiorespiratory Disturbances Associated with Infective Fever in Man: Studies of Ethiopian Louse-Borne Relapsing Fever

1970 • 40 citations

The Role of Regional Body Temperature in the Pathogenesis of Disease

1981 • 38 citations

Endogenous pyrogen‐like substance produced by reptiles.

1977 • 38 citations

Hyperthermic effects of arachidonic acid, prostaglandins E2 and F2? in rats

1978 • 38 citations

Synthesis of four endogenous pyrogens by rabbit macrophages.

1979 • 37 citations

Temperature Regulation

1966 • 37 citations

Hypothalamic sensitivity to leukocytic pyrogen of adult and new‐born guinea‐pigs.

1979 • 37 citations

The aggregation of rat neutrophils by arachidonic acid: a possible bioassay for lipoxygenase activity

1979 • 36 citations

Fever produced by intrahypothalamic pyrogen: Effect of protein synthesis inhibition by anisomycin

1979 • 33 citations

TUMORS AND FEVER

1974 • 33 citations

The effect of fever on temperature regulation in man.

1959 • 32 citations

The role of protein synthesis in the hypothalamic mechanism mediating pyrogen fever

1980 • 31 citations

Observations on the Development of the Febrile Response to Pyrogens in Sheep

1974 • 31 citations

Antagonism by antipyretics of the hyperthermic effect of a prostaglandin precursor, sodium arachidonate, in the cat.

1976 • 31 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1970 • 30 citations

Central effect of taurine and its analogues on fever caused by intravenous leukocytic pyrogen in the rabbit.

1979 • 30 citations

Prostaglandin-sensitive neurones in cat hypothalamus: relation to thermoregulation and to biogenic amines

1977 • 29 citations

Prostaglandins and Body Temperature

1978 • 28 citations

Suppression of fever in rabbits by a protein synthesis inhibitor, anisomycin.

1980 • 28 citations

Temperature regulation, fever, and disease.

1979 • 27 citations

Hyperthermic effect of intraventricular injections of arachidonic acid and prostaglandin E2 in the rat.

1974 • 26 citations

Characteristics of pyrogen production by isolated rabbit Kupffer cells in vitro.

1977 • 25 citations

Depression of preoptic thermosensitivity by bacterial pyrogen in rabbits

1974 • 25 citations

Influence of endogenous pyrogen on the cerebral prostaglandin-synthetase system

1976 • 24 citations

Evidence for the Involvement of Prostaglandins in Fever

2015 • 23 citations

Effects of central administation of probenecid on fevers produced by leukocytic pyrogen and PGE2 in the rabbit.

1979 • 23 citations

Central thermosensitivity during fever produced by intra-PO/AH and intravenous injections of pyrogen

1979 • 21 citations

Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells.

1977 • 21 citations

Body mass and sex as determining factors in the development of fever in rats.

1980 • 21 citations

SPECIES SPECIFICITY OF LEUKOCYTIC PYROGENS

1969 • 21 citations

The febrile responses in rabbits and rats to leucocyte pyrogens of different species.

1978 • 21 citations

The chill sensation in fever

1980 • 21 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1970 • 20 citations

Role of Leucocytes in Fever

1971 • 20 citations

Antipyretic effect of cycloheximide, and inhibitor of protein synthesis, in patients with Hodgkin's disease or other malignant neoplasms.

1975 • 20 citations

Comparison of endogenous pyrogens from human and rabbit leucocytes utilizing Sephadex filtration.

1969 • 20 citations

Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.

1982 • 19 citations

Comparative Observations on the Production of Fever by Bacterial Pyrogens and Leucocytic Pyrogen in Goats and Rabbits

2010 • 19 citations

On the Demonstration of Circulating Human Endogenous Pyrogen

1972 • 19 citations

Hypothermia and Persisting Capacity to Develop Fever

1977 • 18 citations

Analogs of endoperoxide precursors of prostaglandins: Failure to affect body temperature when injected into primary and secondary central temperature controls

1977 • 18 citations

Thermoregulation in rabbits during fever.

1976 • 17 citations

Central Thermoreceptors and Thermoregulation

1972 • 17 citations

The effects of intravenous pyrogen upon the radiant heat induced vasodilatation in man

1959 • 17 citations

Synthesis of four endogenous pyrogens by rabbit macrophages.

1979 • 17 citations

Fever Produced in the Squirrel Monkey by Human Leukocytic Pyrogen

1979 • 17 citations

�ber die Ausl�sung thermoregulatorischer Reaktionen beim Hund unter Pyrogen-Einwirkung

1960 • 15 citations

Sites of Clearance of Leucocyte Pyrogen in the Rabbit

1979 • 15 citations

Effect of cycloheximide on temperature regulation in rats

1979 • 14 citations

Further observations on the suppression of fever in rabbits by intracerebral action of anisomycin.

1982 • 14 citations

THE CEREBRAL EFFECTS OF ENDOGENOUS SERUM AND GRANULOCYTIC PYROGEN.

1965 • 14 citations

Production, Chemistry and Properties of Bacterial Pyrogens and Endotoxins

1971 • 14 citations

A pyrogen derived from human white cells which is active in mice.

1980 • 13 citations

Hyperthermic effect of prostacyclin injected into the third cerebral ventricle of the cat

1979 • 13 citations

The Detection and Characterization of Phagocytic Cells in Established Human Cell Lines Synthesizing Immunoglobulins

1968 • 12 citations

Effects on fever of central administration of transport inhibitors

1979 • 12 citations

Nutritional state and endotoxin fever of newborn rabbits.

1979 • 12 citations

Studies on the Pathogenesis of Fever in Renal Carcinoma

1973 • 12 citations

A dissociation between temperature regulation and fever in the rabbit.

1977 • 11 citations

Influence of pH and Temperature on Behaviour of Surfactant from Human Neonatal Lungs

1978 • 11 citations

Lipid A fever in cats.

1975 • 11 citations

Prostaglandins–A Short Review

1975 • 11 citations

Intraventricular microinjections of a stable analogue of prostaglandin endoperoxide cause fever in rabbits.

1979 • 10 citations

Regional brain salicylate concentrations in afebrile and febrile rabbitts

1973 • 10 citations

Fever induced in rabbits by intravenous injection of bovine serum albumin.

1979 • 9 citations

The Bioassay of Human Endogenous Pyrogen

1973 • 9 citations

Central synaptic interference and experimental fever

1971 • 8 citations

On the pyrogenic action of intravenous lipid A in rabbits.

1982 • 8 citations

[On the induction of thermoregulatory reactions in the dog following the action of pyrogens].

1960 • 7 citations

Analysis of shivering in nonperiheral cooling during pyrogen fever

1975 • 6 citations

Transferable Pyrogen in Human Experimental Fever

1971 • 6 citations

The role of noradrenaline in the rabbit brain during pyrogen-induced fever.

1972 • 5 citations

The integrity of the endotoxin tolerance mechanisms during typhoid fever in man.

1967 • 3 citations

Are the kidneys involved in the removal of endogenous pyrogens in the rabbit?

1982 • 3 citations

Assay of human endogenous pyrogen.

1971 • 2 citations