Fever: Pathogenesis, Pathophysiology, and Purpose

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Iron and infection

1978 • 1,108 citations

“Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation

1969 • 575 citations

Fever and Survival

1975 • 476 citations

Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits

1971 • 358 citations

Neural processes in thermoregulation.

1973 • 286 citations

Human leukocytic pyrogen: purification and development of a radioimmunoassay.

1977 • 269 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1953 • 265 citations

Thermal stimulation of electrical activity of single units of the preoptic region

1963 • 255 citations

THE THERMOSENSITIVITY OF THE HYPOTHALAMUS AND THERMOREGULATION IN MAMMALS

1966 • 215 citations

Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5‐HT on body temperature in conscious rabbits.

1965 • 206 citations

Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs

1960 • 206 citations

Human leukocytic pyrogen induces release of specific granule contents from human neutrophils.

1978 • 206 citations

Survival value of fever in fish

1977 • 204 citations

Pyrogen fever and prostaglandin‐like activity in cerebrospinal fluid

1973 • 204 citations

Fever in the lizard Dipsosaurus dorsalis

1974 • 201 citations

Influence of ambient temperature on the thermoregulatory responses to 5‐hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits

1971 • 200 citations

Prostaglandin E₁ fever induced in rabbits

1973 • 184 citations

Temperature‐sensitive neurones in the dog's hypothalamus

1964 • 180 citations

Observations on the site and mode of action of pyrogens in the rabbit brain

1967 • 179 citations

Fever: Effect of Drug-Induced Antipyresis on Survival

1976 • 179 citations

Fever produced by prostaglandin E₁

1971 • 178 citations

Effect of pyrogen and antipyretics on prostaglandin activity in cisternal c.s.f. of unanaesthetized cats

1973 • 166 citations

TEMPERATURE RESPONSES TO MONOAMINES AND AN INHIBITOR OF MAO INJECTED INTO THE CEREBRAL VENTRICLES OF RATS

1967 • 163 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1955 • 145 citations

Unit responses in the rabbit's brain stem to changes in brain and cutaneous temperature

1969 • 132 citations

The role of sodium and calcium ions in the hypothalamus in the control of body temperature of the unanaesthetized cat

1971 • 130 citations

Perfusion from cerebral ventricle to cisterna magna in the unanaesthetized cat. Effect of calcium on body temperature

1970 • 127 citations

Thermal response patterns of septal and preoptic neurons in cats

1967 • 120 citations

Effect of temperature and pyrogens on single-unit activity in the rabbit's brain stem.

1968 • 112 citations

Temperature-sensitive neurons in preoptic-anterior hypothalamic region: actions of pyrogen and acetylsalicylate

1968 • 110 citations

RELEASE OF AN ENDOGENOUS PYROGEN IN VITRO FROM RABBIT MONONUCLEAR CELLS

1967 • 105 citations

Behavioral Fever in Newborn Rabbits

1976 • 100 citations

Multiple biological activities of a partially purified leukocytic endogenous mediator

1973 • 99 citations

FEVER AS A MECHANISM OF RESISTANCE

1960 • 91 citations

Bactericidal and Metabolic Properties of Human Eosinophils

1972 • 90 citations

Effects of heating and cooling of the spinal cord on preoptic unit activity

1970 • 89 citations

Avian febrile response.

1975 • 88 citations

STUDIES ON THE PATHOGENESIS OF FEVER WITH INFLUENZAL VIRUSES

1958 • 88 citations

Effects of fever on host defense mechanisms after infection in the lizard Dipsosaurus dorsalis.

1978 • 87 citations

Biologically Active Endotoxins from Salmonella Mutants Deficient in O- and R-Polysaccharides and Heptose

1967 • 83 citations

Fever and survival: the role of serum iron.

1978 • 83 citations

Fever produced by microinjection of typhoid vaccine into hypothalamus of cats

1965 • 82 citations

Thermoregulation during fever: Change of set-point or change of gain

1970 • 81 citations

Central nervous system sites of action of a purified leucocyte pyrogen

1971 • 80 citations

STUDIES ON THE MECHANISM OF ENDOGENOUS PYROGEN PRODUCTION

1974 • 79 citations

Behavioral fever in anuran amphibian larvae

1977 • 78 citations

A hypothalamic region responsive to localized injection of pyrogens.

1967 • 77 citations

Central Control of Heat Loss Mechanisms in the Gost.

1956 • 76 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1967 • 74 citations

Further purification of group A streptococcal pyrogenic exotoxin and characterization of the purified toxin

1976 • 73 citations

STUDIES ON THE ORIGIN OF HUMAN LEUKOCYTIC PYROGEN

1970 • 70 citations

Bahavioral fever in crayfish

1977 • 69 citations

Fever in the frog Hyla Cinerea

1977 • 69 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1964 • 67 citations

The Production of Antibody against Human Leukocytic Pyrogen

1977 • 66 citations

Evidence that brain prostaglandin synthesis is not essential in fever.

1976 • 65 citations

Further purification of rabbit leukocyte pyrogen.

1974 • 65 citations

STUDIES ON TUBERCULIN FEVER

1959 • 63 citations

A dissociation between fever and prostaglandin concentration in cerebrospinal fluid.

1975 • 63 citations

PGE1 fever: its effect on thermoregulation at different low ambient temperatures

1974 • 62 citations

The Regulation of Body Temperature During Fever

1965 • 61 citations

TEMPERATURE REGULATION DURING FEVER IN MAN.

1964 • 61 citations

THE PRODUCTION OF FEVER BY INFLUENZAL VIRUSES

1949 • 57 citations

THE ENDOTOXIC PROPERTIES OF LYSATES OF GROUP A HEMOLYTIC STREPTOCOCCI

1956 • 55 citations

FEVER FROM PATHOGENIC FUNGI *

1960 • 53 citations

Postnatal development of pyrogenic sensitivity in guinea pigs

1975 • 52 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1957 • 52 citations

Human Leukocyte Pyrogen Producing Fever in Rabbits.

1966 • 52 citations

The effects of cyclic adenosine 3',5'‐monophosphate and other adenine nucleotides on body temperature.

1975 • 51 citations

STUDIES ON THE MECHANISM OF FEVER ACCOMPANYING DELAYED HYPERSENSITIVITY

1972 • 50 citations

Persistence of febrile response to pyrogens after PO/AH lesions in squirrel monkeys

1976 • 50 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1958 • 50 citations

Leukocytic pyrogen and sodium acetylsalicylate on hypothalamic neurons in the cat

1975 • 49 citations

Neutrophil Releasing Activity in Rats Injected with Endogenous Pyrogen

1972 • 48 citations

Studies on steroid fever

1968 • 48 citations

Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits.

1977 • 47 citations

Serotonin, Norepinephrine, and Fever

1968 • 46 citations

Factors affecting the quantitative production and assay of human leukocytic pyrogen.

1970 • 45 citations

The thermoregulatory effects of prostaglandin E 1 when infused into a lateral cerebral ventricle of the Welsh Mountain sheep at different ambient temperatures.

1973 • 44 citations

Relationship of Body Temperature to the Lethal Action of Bacterial Endotoxin*

1964 • 44 citations

Studies on the mechanism of endogenous pyrogen production. I. Investigation of new protein synthesis in stimulated human blood leucocytes.

1970 • 44 citations

The release of an endogenous pyrogen from guinea pig leukocytes in vitro: a new model for investigating the role of lymphocytes in fevers induced by antigen in hosts with delayed hypersensitivity.

1977 • 43 citations

SYNTHESIS OF ENDOGENOUS PYROGEN BY RABBIT LEUKOCYTES

1973 • 43 citations

The influence of artificial fever on mechanisms of resistance

1942 • 42 citations

PATHOGENETIC MECHANISMS IN EXPERIMENTAL IMMUNE FEVER

1968 • 42 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1964 • 41 citations

Pyrogen and prostaglandin fever in the rabbit—I: Effects of salicylate and the role of cyclic AMP

1975 • 41 citations

Fever: Reciprocal Shift in Brain Sodium to Calcium Ratio as the Set-Point Temperature Rises

1972 • 40 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1962 • 39 citations

Endogenous pyrogen‐like substance produced by reptiles.

1977 • 38 citations

Pyrogen and prostaglandin fever in the rabbit—II: Effects of noradrenaline depletion and adrenergic receptor blockade

1975 • 37 citations

TUMORS AND FEVER

1974 • 33 citations

Partial purification of human leukocytic pyrogen

1977 • 32 citations

The effect of fever on temperature regulation in man.

1959 • 32 citations

Interactions of gram-negative bacterial endotoxin with rabbit blood in vitro

1967 • 32 citations

Observations on the Development of the Febrile Response to Pyrogens in Sheep

1974 • 31 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1970 • 30 citations

STUDIES IN STAPHYLOCOCCAL FEVER. I. RESPONSES TO BACTERIAL CELLS.

1963 • 29 citations

Febrile and hematologic responses of rhesus monkeys to bacterial endotoxin

1967 • 28 citations

Spontaneous pyrogen production by mouse histiocytic and myelomonocytic tumor cell lines in vitro.

1978 • 27 citations

Evidence for the involvement of adenosine 3?,5?-cyclic monophosphate in fever genesis

1976 • 27 citations

Colchicine stimulation of pyrogen production by human blood leukocytes.

1976 • 27 citations

THE PASSIVE TRANSFER OF SENSITIVITY TO ANTIGEN-INDUCED FEVER*

1961 • 26 citations

Pathogenesis of fever in delayed hypersensitivity: factors influencing release of pyrogen-inducing lymphokines

1978 • 25 citations

Pathogenesis of fever in delayed hypersensitivity: role of monocytes

1978 • 25 citations

Characteristics of pyrogen production by isolated rabbit Kupffer cells in vitro.

1977 • 25 citations

Depression of preoptic thermosensitivity by bacterial pyrogen in rabbits

1974 • 25 citations

Studies on the pathogenesis of fever. V. The fever accompanying pneumococcal infection in the rabbit.

1956 • 24 citations

Cyclic adenosine 3', 5'‐monophosphate in cerebrospinal fluid during thermoregulation and fever.

1976 • 23 citations

Pyrogenic Responses to Staphylococcal Enterotoxins A and B in Cats

1968 • 23 citations

The Relationship of Complement Consumption to Immune Fever

1971 • 22 citations

The association of fever and antibody response in rabbits immunized with human serum albumin.

1966 • 22 citations

Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells.

1977 • 21 citations

SPECIES SPECIFICITY OF LEUKOCYTIC PYROGENS

1969 • 21 citations

Comparison of endogenous pyrogens from human and rabbit leucocytes utilizing Sephadex filtration.

1969 • 20 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1970 • 20 citations

Reaction of squirrel monkeys to intratracheal inoculation with influenza/A/New Jersey/76 (swine) virus

1977 • 19 citations

Effect of Artificial Fever in Increasing Susceptibility to Bacterial Endotoxin

1961 • 19 citations

On the Demonstration of Circulating Human Endogenous Pyrogen

1972 • 19 citations

STUDIES ON THE MECHANISM OF PENICILLIN-INDUCED FEVER

1972 • 19 citations

Purification of an Endogenous Pyrogen, with an Appendix on Assay Methods

1971 • 16 citations

Studies on the pathogenesis of fever. VII. Comparative observations on the production of fever by inflammatory exudates in rabbits and dogs.

1957 • 15 citations

The effect of sodium salicylate on dibutyryl cyclic amp fever in the conscious rabbit

1976 • 14 citations

The pyrogenic effect of scarlet fever toxin

1966 • 14 citations

Pyrogenic properties of human pathological fluids.

1962 • 14 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1970 • 14 citations

Hypothalamic heating and cooling in monoamine-depleted rabbits

1975 • 13 citations

Production of fever in rabbits with extracts of tissue culture cells infected with Coxsackie virus.

1962 • 12 citations

Immune Fever in the Rabbit: Responses of the Hematologic and Complement Systems

1971 • 12 citations

A dissociation between temperature regulation and fever in the rabbit.

1977 • 11 citations

Influence of tobacco smoking upon the effectiveness of antacid therapy and management of the peptic ulcer patient.

1948 • 11 citations

Studies in cryptococcal fever. I. Responses to intact organisms and to a soluble agent derived from cryptococci.

1966 • 9 citations

Fever and thermogenesis.

1976 • 9 citations

Neurochemistry of fever.

1976 • 8 citations

Central nervous region essential for endotoxin fever.

1962 • 6 citations

STUDIES ON THE PATHOGENESIS OF FEVER

1970 • 6 citations