Global properties of biological networks

Collective dynamics of ‘small-world’ networks

1998 • 40,646 citations

The Protein Data Bank

2000 • 35,287 citations

Emergence of Scaling in Random Networks

1999 • 34,466 citations

Network Motifs: Simple Building Blocks of Complex Networks

2002 • 7,026 citations

Error and attack tolerance of complex networks

2000 • 6,651 citations

Lethality and centrality in protein networks

2001 • 5,197 citations

The small-world problem

1967 • 4,929 citations

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

2000 • 4,734 citations

The large-scale organization of metabolic networks

2000 • 4,250 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

From molecular to modular cell biology

1999 • 3,617 citations

Classes of small-world networks

2000 • 3,049 citations

Specificity and Stability in Topology of Protein Networks

2002 • 2,964 citations

Small worlds: the dynamics of networks between order and randomness

2000 • 2,444 citations

Evidence for dynamically organized modularity in the yeast protein–protein interaction network

2004 • 1,798 citations

Protein complexes and functional modules in molecular networks

2003 • 1,439 citations

The protein–protein interaction map of Helicobacter pylori

2001 • 1,134 citations

The small world inside large metabolic networks

2001 • 1,000 citations

A minimal gene set for cellular life derived by comparison of complete bacterial genomes.

1996 • 911 citations

Structure and evolution of transcriptional regulatory networks

2004 • 751 citations

Modeling interactome: scale-free or geometric?

2004 • 692 citations

From magic bullets to designed multiple ligands

2004 • 689 citations

Functional and topological characterization of protein interaction networks

2004 • 606 citations

The structure of the protein universe and genome evolution

2002 • 559 citations

The Yeast Protein Interaction Network Evolves Rapidly and Contains Few Redundant Duplicate Genes

2001 • 539 citations

Large-scale analysis of the yeast genome by transposon tagging and gene disruption

1999 • 536 citations

Domain combinations in archaeal, eubacterial and eukaryotic proteomes

2001 • 478 citations

Connectivity of random nets

1951 • 459 citations

Assessing experimentally derived interactions in a small world

2003 • 403 citations

The connectivity structure, giant strong component and centrality of metabolic networks

2003 • 393 citations

Small-world view of the amino acids that play a key role in protein folding

2002 • 386 citations

Classification of scale-free networks

2002 • 374 citations

The Protein Folding Network

2004 • 351 citations

Gene co-expression network topology provides a framework for molecular characterization of cellular state

2004 • 350 citations

Small-World Communication of Residues and Significance for Protein Dynamics

2004 • 330 citations

The metabolic world of Escherichia coli is not small

2004 • 319 citations

Protein family and fold occurrence in genomes: power-law behaviour and evolutionary model

2001 • 290 citations

Uncovering Network Systems Within Protein Structures

2003 • 287 citations

How the global structure of protein interaction networks evolves

2003 • 271 citations

Scale-Free Behavior in Protein Domain Networks

2001 • 262 citations

A natural class of robust networks

2003 • 252 citations

The yeast coexpression network has a small‐world, scale‐free architecture and can be explained by a simple model

2004 • 252 citations

The identification of functional modules from the genomic association of genes

2002 • 251 citations

Jamming is limited in scale-free systems

2004 • 228 citations

Preferential Attachment in the Protein Network Evolution

2003 • 217 citations

Subgraphs in random networks

2003 • 216 citations

Exploring the pathway structure of metabolism: decomposition into subnetworks and application to Mycoplasma pneumoniae

2002 • 209 citations

Conservation and Coevolution in the Scale-Free Human Gene Coexpression Network

2004 • 199 citations

Network Topology of a Potential Energy Landscape: A Static Scale-Free Network

2002 • 196 citations

Wrestling with pleiotropy: Genomic and topological analysis of the yeast gene expression network

2002 • 184 citations

Expanding protein universe and its origin from the biological Big Bang

2002 • 177 citations

Mapping protein family interactions: intramolecular and intermolecular protein family interaction repertoires in the PDB and yeast11Edited by J. Karn

2001 • 173 citations

Evolution and Topology in the Yeast Protein Interaction Network

2004 • 143 citations

The topology of the transcription regulatory network in the yeast, Saccharomyces cerevisiae

2003 • 130 citations

Strong links are important, but weak links stabilize them

2004 • 126 citations

An insight into domain combinations

2001 • 125 citations

Bioactive components in milk

2002 • 121 citations

From topology to dynamics in biochemical networks

2001 • 102 citations

From large networks to small molecules

2003 • 97 citations

Convergent evolution of gene networks by single‐gene duplications in higher eukaryotes

2004 • 92 citations

Interaction and domain networks of yeast

2002 • 88 citations

The proteomic approach to analysis of human milk fat globule membrane

2004 • 80 citations

Unraveling protein interaction networks with near-optimal efficiency

2003 • 79 citations

Functional Evolution of the Yeast Protein Interaction Network

2004 • 67 citations

The society of genes: networks of functional links between genes from comparative genomics

2002 • 64 citations

The nonconserved wrapping of conserved protein folds reveals a trend toward increasing connectivity in proteomic networks

2004 • 34 citations

II. Supplementary remarks on the porism of the in-and-circum-scribed triangle

1857 • 30 citations

Disease genes and intracellular protein networks

2003 • 23 citations

Mining DNA microarray data using a novel approach based on graph theory

2001 • 20 citations

Inherent size constraints on prokaryote gene networks due to ?accelerating? growth

2005 • 17 citations

Network structure of metabolic pathways

2001 • 16 citations

Inherent size constraints on prokaryote gene networks due to "accelerating" growth

2003 • 2 citations

An Exact Model of Fluctuations in Gene Expression

2004 • 2 citations

Global Topological Study of the Protein-protein Interaction Networks

2004 • 1 citations