Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

Repeated observation of breast tumor subtypes in independent gene expression data sets

2003 • 5,356 citations

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2003 • 4,433 citations

Comparison of Discrimination Methods for the Classification of Tumors Using Gene Expression Data

2002 • 2,703 citations

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

2005 • 2,658 citations

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

2001 • 2,626 citations

Support vector machine classification and validation of cancer tissue samples using microarray expression data

2000 • 2,446 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Polychemotherapy for early breast cancer: an overview of the randomised trials

1998 • 2,023 citations

Breast cancer classification and prognosis based on gene expression profiles from a population-based study

2003 • 2,013 citations

Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

1999 • 1,410 citations

Predicting the clinical status of human breast cancer by using gene expression profiles

2001 • 1,336 citations

Clinical Course of Breast Cancer Patients With Complete Pathologic Primary Tumor and Axillary Lymph Node Response to Doxorubicin-Based Neoadjuvant Chemotherapy

1999 • 1,315 citations

Improved Outcomes From Adding Sequential Paclitaxel but Not From Escalating Doxorubicin Dose in an Adjuvant Chemotherapy Regimen for Patients With Node-Positive Primary Breast Cancer

2003 • 1,286 citations

Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

2002 • 1,114 citations

Fundamentals of experimental design for cDNA microarrays

2002 • 1,070 citations

Prediction of cancer outcome with microarrays: a multiple random validation strategy

2005 • 982 citations

Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer

2003 • 889 citations

National Institutes of Health Consensus Development Conference Statement: Adjuvant Therapy for Breast Cancer, November 1-3, 2000

2001 • 888 citations

Outcome signature genes in breast cancer: is there a unique set?

2004 • 798 citations

Metastasis genes: A progression puzzle

2002 • 793 citations

limmaGUI: A graphical user interface for linear modeling of microarray data

2004 • 725 citations

Meeting Highlights: Updated International Expert Consensus on the Primary Therapy of Early Breast Cancer

2003 • 706 citations

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns.

2001 • 672 citations

Gene expression predictors of breast cancer outcomes

2003 • 631 citations

erbB-2, p53, and Efficacy of Adjuvant Therapy in Lymph Node-Positive Breast Cancer

1998 • 628 citations

Gene Expression Profiles Predict Complete Pathologic Response to Neoadjuvant Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy in Breast Cancer

2004 • 545 citations

Navigating gene expression using microarrays — a technology review

2001 • 537 citations

Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling

2003 • 464 citations

Different Gene Expression Patterns in Invasive Lobular and Ductal Carcinomas of the Breast

2004 • 431 citations

Gene expression profiles of primary breast tumors maintained in distant metastases

2003 • 430 citations

Amplification and Deletion of Topoisomerase IIα Associate with ErbB-2 Amplification and Affect Sensitivity to Topoisomerase II Inhibitor Doxorubicin in Breast Cancer

2000 • 388 citations

DNA Microarrays in Clinical Oncology

2002 • 383 citations

Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis

1986 • 382 citations

Chemotherapy Is More Effective in Patients with Breast Cancer Not Expressing Steroid Hormone Receptors

2004 • 348 citations

Molecular Classification of Tamoxifen-Resistant Breast Carcinomas by Gene Expression Profiling

2005 • 331 citations

Gene Expression Patterns in Ovarian Carcinomas

2003 • 320 citations

A Cell Proliferation Signature Is a Marker of Extremely Poor Outcome in a Subpopulation of Breast Cancer Patients

2005 • 261 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 258 citations

Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy

2003 • 258 citations

Prognostic significance of a complete pathological response after induction chemotherapy in operable breast cancer

2002 • 250 citations

Gene Expression Profiling Identifies Molecular Subtypes of Inflammatory Breast Cancer

2005 • 242 citations

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

2002 • 231 citations

Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors.

2003 • 231 citations

Tissue ischemia time affects gene and protein expression patterns within minutes following surgical tumor excision

2004 • 227 citations

Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer

2002 • 225 citations

Between-group analysis of microarray data

2002 • 225 citations

Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes

2004 • 220 citations

Design of studies using DNA microarrays

2002 • 196 citations

Microarray platforms – comparisons and contrasts

2004 • 196 citations

Gene Expression Profiling for Molecular Characterization of Inflammatory Breast Cancer and Prediction of Response to Chemotherapy

2004 • 193 citations

Molecular classification of familial non- BRCA1/BRCA2 breast cancer

2003 • 183 citations

Cell-Type-Specific Responses to Chemotherapeutics in Breast Cancer

2004 • 182 citations

Total RNA yield and microarray gene expression profiles from fine‐needle aspiration biopsy and core‐needle biopsy samples of breast carcinoma

2003 • 176 citations

The Antiepidermal Growth Factor Receptor Agent Gefitinib (ZD1839/Iressa) Improves Antihormone Response and Prevents Development of Resistance in Breast Cancer in Vitro

2003 • 169 citations

The poor responsiveness of infiltrating lobular breast carcinomas to neoadjuvant chemotherapy can be explained by their biological profile

2003 • 159 citations

Stanniocalcin 2 is an estrogen-responsive gene coexpressed with the estrogen receptor in human breast cancer.

2002 • 147 citations

Different responses to preoperative chemotherapy for invasive lobular and invasive ductal breast carcinoma

2003 • 147 citations

Cross-platform comparison and visualisation of gene expression data using co-inertia analysis

2003 • 144 citations

Identification and validation of an ERBB2 gene expression signature in breast cancers

2004 • 130 citations

Trends in mortality from major cancers in the European Union, including acceding countries, in 2004

2004 • 126 citations

Prognostic meta-signature of breast cancer developed by two-stage mixture modeling of microarray data

2004 • 126 citations

Linking gene expression patterns to therapeutic groups in breast cancer.

2000 • 122 citations

Expression profiling to predict postoperative prognosis for estrogen receptor‐negative breast cancers by analysis of 25,344 genes on a cDNA microarray

2004 • 121 citations

Response to primary chemotherapy in breast cancer patients with tumors not expressing estrogen and progesterone receptors

2000 • 113 citations

Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib (`Iressa', ZD1839)

2004 • 111 citations

Bevacizumab in the Treatment of Breast Cancer: Rationale and Current Data

2004 • 110 citations

Gene expression profiling detects gene amplification and differentiates tumor types in breast cancer.

2003 • 103 citations

Molecular profiling of breast cancer: clinical implications

2004 • 98 citations

Global Gene Expression Changes During Neoadjuvant Chemotherapy for Human Breast Cancer

2002 • 97 citations

Methods and approaches in the analysis of gene expression data

2001 • 88 citations

Model for breast cancer survival: relative prognostic roles of axillary nodal status, TNM stage, estrogen receptor concentration, and tumor necrosis.

1988 • 82 citations

Molecular classification of breast cancer patients by gene expression profiling*

2001 • 75 citations

Preoperative/neoadjuvant medical therapy for early breast cancer

2001 • 75 citations

A study of inter-lab and inter-platform agreement of DNA microarray data

2005 • 65 citations

Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies

2001 • 51 citations

New targeted therapies in breast cancer

2004 • 49 citations

Importance of orthotopic transplantation procedures in assessing the effects of transfected genes on human tumor growth and metastasis

1991 • 45 citations

Expression profiling to predict outcome in breast cancer: the influence of sample selection

2002 • 44 citations

Comments on the St. Gallen Consensus 2003 on the Primary Therapy of Early Breast Cancer

2003 • 40 citations

Characterization of adjacent breast tumors using oligonucleotide microarrays

2001 • 37 citations

Prognosis of Breast Cancer and Gene Expression Profiling Using DNA Arrays

2002 • 36 citations

Current Status and Future Directions in Breast Cancer Therapy

2003 • 33 citations

Gene expression profiles in breast tumors regarding the presence or absence of estrogen and progesterone receptors

2004 • 30 citations

Determination of Clinical Utility of Tumor Markers: A Tumor Marker Utility Grading System

1998 • 24 citations

An Unsupervised Approach to Identify Molecular Phenotypic Components Influencing Breast Cancer Features

2004 • 23 citations

Gene-expression profiling in breast cancer

2005 • 20 citations

Microarray Technologies 2003 - An Overview

2003 • 20 citations

New data on chemotherapy in the adjuvant setting

2003 • 19 citations

Gemcitabine plus docetaxel administered every other week as first-line treatment of metastatic breast cancer: Preliminary results from a phase II trial

2004 • 17 citations

Anti-estrogens in the treatment of breast cancer: current status and future directions.

2003 • 17 citations

Trial and Error: Prognostic Gene Signature Study Design Altered

2005 • 7 citations

[Gene expression profiling using cDNA arrays and prognosis of breast cancer].

2002 • 3 citations