Structure/activity relations of N-methyl-d-aspartate receptor ligands as studied by their inhibition of [3H]d2-amino-5-phosphonopentanoic acid binding in rat brain membranes

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Chemistry of the amino acids

1961 • 1,404 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

1982 • 834 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Agonists and antagonists for excitatory amino acid receptors

1987 • 692 citations

Hypoglycemia-Induced Neuronal Damage Prevented by an N -Methyl-D-Aspartate Antagonist

1985 • 673 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

THE EFFECTS OF A SERIES OF ω‐PHOSPHONIC α‐CARBOXYLIC AMINO ACIDS ON ELECTRICALLY EVOKED AND EXCITANT AMINO ACID‐INDUCED RESPONSES IN ISOLATED SPINAL CORD PREPARATIONS

1982 • 463 citations

Excitatory amino acid transmission

1987 • 430 citations

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]d-AP5 binding sites on brain membranes and anticonvulsant activity

1986 • 311 citations

Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord

1982 • 302 citations

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

1984 • 293 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Glutamate transmitter in the central nervous system

1982 • 259 citations

Excitatory amino acids in health and disease.

1988 • 254 citations

Action of 3-((±)-2-car☐ypiperazin-4-yl)-propyl-1-phosphonic aci (CPP): a new and highly potent antagonist of N-methyl-d-aspartate receptors in the hippocampus

1986 • 239 citations

Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities.

1984 • 238 citations

Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.

1983 • 209 citations

Binding of [3H]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membranes: a selective, high-affinity ligand for N-methyl-D-aspartate receptors.

1987 • 203 citations

STRUCTURE‐ACTIVITY RELATIONS OF EXCITATORY AMINO ACIDS ON FROG AND RAT SPINAL NEURONES

1976 • 195 citations

Muscle relaxant and anticonvulsant activity of 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel antagonist, in rodents

1987 • 189 citations

High concentrations of N-acetylaspartylglutamate (NAAG) selectively activate NMDA receptors on mouse spinal cord neurons in cell culture

1986 • 181 citations

l-[3H]Glutamate binds to kainate-, NMDA- and AMPA-sensitive binding sites: an autoradiographic analysis

1985 • 170 citations

Differential activation and blockade of excitatory amino acid receptors in the mammalian and amphibian central nervous systems

1982 • 155 citations

ANTAGONISM OF EXCITATORY AMINO ACID‐INDUCED RESPONSES AND OF SYNAPTIC EXCITATION IN THE ISOLATED SPINAL CORD OF THE FROG

1979 • 152 citations

N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.

1985 • 148 citations

ACTIONS OF AMINO‐ACIDS ON THE ISOLATED HEMISECTED SPINAL CORD OF THE TOAD

1997 • 139 citations

Chemical Society, London

1878 • 136 citations

Excitatory Amino Acids

1986 • 135 citations

N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.

1983 • 124 citations

ACTIONS OF AMINO‐ACIDS ON THE ISOLATED HEMISECTED SPINAL CORD OF THE TOAD

1961 • 124 citations

Comparison of L-[3H]glutamate, D-[3H]aspartate, DL-[3H]AP5 and [3H]NMDA as ligands for NMDA receptors in crude postsynaptic densities from rat brain

1987 • 111 citations

A comparison of excitatory amino acid antagonists acting at primary afferent C fibres and motoneurones of the isolated spinal cord of the rat

1987 • 109 citations

[3H]CPP, a new competitive ligand for NMDA receptors

1986 • 108 citations

2-amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam

1986 • 108 citations

Glutamic acid: Advances in biochemistry and physiology

1980 • 96 citations

Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus

1985 • 95 citations

Mg2+-like selective antagonism of excitatory amino acid-induced responses by α,ε-diaminopimelic acid, D-α-maminoadipate and HA-966 in isolated spinal cord of frog and immature rat

1978 • 93 citations

Structure-activity relations of dipeptide antagonists of excitatory amino acids

1984 • 88 citations

The Synthesis of Some Acidic Amino Acids Possessing Neuropharmacological Activity

1962 • 83 citations

Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-α-aminoadipate, α,ϵ-diaminopimelic acid and HA-966

1977 • 76 citations

Synthesis of [3H]2-Amino-4-phosphonobutyric acid and characterization of its binding to rat brain membranes: a selective ligand for the chloride/calcium-dependent class ofl-glutamate binding sites

1983 • 74 citations

The neurolathyrogen, β-N-oxalyl-L-α,β-diaminopropionic acid, is a potent agonist at ‘glutamate preferring’ receptors in the frog spinal cord

1981 • 69 citations

Characterization of the binding of <scp>dl</scp>‐[³H]‐2‐amino‐4‐phosphonobutyrate to <scp>l</scp>‐glutamate‐sensitive sites on rat brain synaptic membranes

1983 • 62 citations

Isomers of 2-amino-7-phosphonoheptanoic acid as antagonists of neuronal excitants

1982 • 60 citations

[3H]D-2-amino-5-phosphonopentanoate as a ligand for N-methyl-d-aspartate receptors in the mammalian central nervous system

1988 • 56 citations

Dipeptide Antagonists of Amino Acid‐Induced and Synaptic Excitation in the Frog Spinal Cord

1980 • 56 citations

Pharmacology of the excitatory actions of sulphonic and sulphinic amino acids.

1983 • 48 citations

Phosphono dipeptides and piperazine derivatives as antagonists of amino acid-induced and synaptic excitation in mammalian and amphibian spinal cord

1984 • 43 citations

A comparison of the effects of N-methyl-d-aspartate and quinolinate on central neurones of the rat

1984 • 43 citations

Specific binding of heptanoic acid to rat brain membranes in vitro

1983 • 39 citations

Excitant activity of methyl derivatives of quinolinic acid on rat cortical neurones

1984 • 28 citations

Molecular target size of NMDA antagonist binding sites

1987 • 27 citations

Conformational aspects of the actions of some piperidine dicarboxylic acids at excitatory amino acid receptors in the mammalian and amphibian spinal cord

1982 • 27 citations

Quantitative studies of N-methyl-D-aspartate, 2-amino-5- phosphonovalerate and cis-2,3-piperidine dicarboxylate interactions on the neonatal rat spinal cord in vitro

1986 • 13 citations

(±)-cis-2,3-piperidine dicarboxylic acid is a partial n-methy-d-aspartate agonist in the in vitro rat cerebellar cGMP model

1986 • 10 citations

Ionic regulation of the binding of dl-2-amino-7-phosphono-[4,5-3H]heptanoic acid to synaptosome-enriched homogenates of rat cerebral cortex

1986 • 4 citations