Resistance mutations selected in vivo under therapy with anti-HIV drug HBY 097 differ from resistance pattern selected in vitro

HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time

1996 • 3,496 citations

Viral dynamics in human immunodeficiency virus type 1 infection

1995 • 3,277 citations

Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor

1992 • 1,887 citations

Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.

1993 • 1,097 citations

A Randomized, Double-blind Trial Comparing Combinations of Nevirapine, Didanosine, and Zidovudine for HIV-Infected Patients

1998 • 777 citations

Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

1994 • 584 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection1Presented at the Eleventh International Conference on Antiviral Research, San Diego, CA, 5–10 April 1998.1

1998 • 351 citations

High-Dose Nevirapine: Safety, Pharmacokinetics, And Antiviral Effect In Patients With Human Immunodeficiency Virus Infection

1995 • 306 citations

Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group

1993 • 296 citations

Recombination leads to the rapid emergence of HIV-1 dually resistant mutants under selective drug pressure.

1996 • 242 citations

3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors

1992 • 236 citations

Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing

1993 • 200 citations

Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients

1996 • 194 citations

HIV‐1‐specific RT inhibitors: Highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase

1993 • 166 citations

Analysis of a rape case by direct sequencing of the human immunodeficiency virus type 1 pol and gag genes

1994 • 160 citations

A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase

1993 • 147 citations

Drug Evaluations Anti-infectives: Nevirapine: A review of its development, pharmacological profile and potential for clinical use

1996 • 132 citations

Genotypic And Phenotypic Analysis Of Human Immunodeficiency Virus Type 1 Isolates From Patients On Prolonged Stavudine Therapy

1994 • 123 citations

Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors.

1996 • 117 citations

Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication

1993 • 117 citations

Treatment of human immunodeficiency virus type 1 (HIV-1)-infected cells with combinations of HIV-1-specific inhibitors results in a different resistance pattern than does treatment with single-drug therapy

1993 • 107 citations

Isolation frequency and growth properties of HIV‐variants: Multiple simultaneous variants in a patient demonstrated by molecular cloning

1987 • 101 citations

Rapid Genetic Characterization of HIV Type 1 Strains from Four World Health Organization-Sponsored Vaccine Evaluation Sites Using a Heteroduplex Mobility Assay

1994 • 87 citations

Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication

1995 • 85 citations

HIV-1 RNA serum-load and resistant viral genotypes during early zidovudine therapy

1995 • 85 citations

Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.

1996 • 83 citations

Clinical correlates of in vitro HIV-1 resistance to zidovudine. Results of the Multicentre Canadian AZT Trial

1993 • 68 citations

What can be Expected from Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) in the Treatment of Human Immunodeficiency Virus Type 1 (HIV-1) Infections?

1996 • 67 citations

Standard Conditions of Virus Isolation Reveal Biological Variability of HIV Type 1 in Different Regions of the World

1994 • 58 citations

Combination Therapy with Zidovudine Prevents Selection of Human Immunodeficiency Virus Type 1 Variants Expressing High-Level Resistance to L-697,661, a Nonnucleoside Reverse Transcriptase Inhibitor

1995 • 53 citations

Mutational Analysis of Residue 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

1994 • 45 citations

Systematic classification of HIV biological subtypes on lymphocytes and monocytes/macrophages

1990 • 41 citations

Assessment of Antiretroviral Therapy by Plasma Viral Load Testing

1995 • 38 citations

In VitroSelection for Different Mutational Patterns in the HIV-1 Reverse Transcriptase Using High and Low Selective Pressure of the Nonnucleoside Reverse Transcriptase Inhibitor HBY 097

1997 • 34 citations

Comparison of cord blood and peripheral blood mononuclear cells as targets for viral isolation and drug sensitivity studies involving human immunodeficiency virus type 1

1994 • 33 citations

Markers for HIV-disease progression in untreated patients and patients receiving AZT: Evaluation of viral activity, AZT resistance, serum cholesterol, β2-microglobulin, CD4+ cell counts, and HIV antigen

1991 • 19 citations

Preliminary structural analysis of the mutations selected by non-nucleoside inhibitors of HIV-1 reverse transcriptase

1993 • 10 citations

Biochemical and genetical analysis of AZT-resistant HIV-mutants.

1991 • 5 citations