X‐ray diffraction and far‐UV CD studies of filaments formed by a leucine‐rich repeat peptide: structural similarity to the amyloid fibrils of prions and Alzheimer's disease β‐protein

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases.

1994 • 1,065 citations

Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes

1997 • 838 citations

Fatal Familial Insomnia and Familial Creutzfeldt-Jakob Disease: Disease Phenotype Determined by a DNA Polymorphism

1992 • 680 citations

Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

1993 • 614 citations

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation.

1986 • 553 citations

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

1987 • 475 citations

“Cross-β” conformation in proteins

1968 • 392 citations

Proteins with leucine-rich repeats

1995 • 388 citations

pH-dependent structural transitions of Alzheimer amyloid peptides

1991 • 376 citations

Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C).

1986 • 332 citations

The α-Helical to β-Strand Transition in the Amino-terminal Fragment of the Amyloid β-Peptide Modulates Amyloid Formation

1995 • 319 citations

Structural and functional diversity in the leucine-rich repeat family of proteins

1996 • 311 citations

Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction

1993 • 275 citations

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.

1994 • 260 citations

X-ray Diffraction of Scrapie Prion Rods and PrP Peptides

1995 • 165 citations

The parallel β helix and other coiled folds

1995 • 101 citations

A leucine‐rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a β‐sheet structure

1991 • 70 citations

Creation of amyloid fibrils from mutant Asn187 gelsolin peptides

1992 • 40 citations