Endogenous opioids in cerebrospinal fluid of opioid-dependent humans

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Characteristics of the “Receptor” for Narcotic Analgesics in Synaptic Plasma Membrane Fraction from Rat Brain

1973 • 426 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Morphine-like ligand for opiate receptors in human CSF

1975 • 281 citations

Physiological parameters of morphine dependence in man—Tolerance, early abstinence, protracted abstinence

1969 • 264 citations

ACUPUNCTURE IN HEROIN ADDICTS: CHANGES IN MET-ENKEPHALIN AND $beta;-ENDORPHIN IN BLOOD AND CEREBROSPINAL FLUID

1979 • 210 citations

Naltrexone-induced opiate receptor supersensitivity

1982 • 195 citations

Stability of Met-enkephalin content in brain structures of morphine-dependent or foot shock-stressed rats

1977 • 139 citations

Supersensitivity to opioids following the chronic blockade of endorphin action by naloxone

1979 • 109 citations

Radioimmunoassay of enkephalins

1977 • 98 citations

Enkephalin: Radioimmunoassay and radioreceptor assay in morphine dependent rats

1977 • 88 citations

Long-term morphine treatment decreases endorphin levels in rat brain and pituitary

1979 • 73 citations

Beta-endorphin-like immunoactivity in the plasma of heroin addicts and normal subjects

1980 • 61 citations

Characterization of electrophoretically separable endorphins in human CSF

1983 • 56 citations

Inquiry into endorphinergic feedback mechanisms during the development of opiate tolerance/dependence

1980 • 46 citations

Psychiatric disorders in opioid-dependent patients.

1984 • 43 citations

Diazepam-induced release of opioid activity in the rat brain

1980 • 39 citations

Enkephalin-containing polypeptides in human cerebrospinal fluid

1986 • 38 citations

Enkephalin levels decrease in rat striatum during morphine abstinence

1979 • 37 citations

Endorphin levels in human cerebrospinal fluid during alcohol intoxication and withdrawal

1982 • 37 citations

Beta endorphin levels in CSF during methadone maintenance

1987 • 37 citations

ENDORPHIN LEVELS IN OPIOID‐DEPENDENT HUMAN SUBJECTS: A LONGITUDINAL STUDY*

1982 • 24 citations

CSF-Endorphins in Heroin Addicts during Methadone Maintenance and during Withdrawal

1981 • 20 citations

Heroin Addiction: Beta-Endorphin Immunoreactivity in Plasma Increases During Withdrawal

1983 • 19 citations

Electrophoresis of opioid peptides on columns with agarose suspension

1983 • 15 citations

Depression and CSF endorphin fraction I: Seasonal variation and higher levels in unipolar than bipolar patients

1983 • 15 citations