Genetic Diversity and Evolution of Retroviruses

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Origin and evolution of retroelements based upon their reverse transcriptase sequences.

1990 • 1,351 citations

Redesign of Retrovirus Packaging Cell Lines To Avoid Recombination Leading to Helper Virus Production

1986 • 1,276 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

The Accuracy of Reverse Transcriptase from HIV-1

1988 • 982 citations

Fidelity of HIV-1 Reverse Transcriptase

1988 • 919 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

RNA tumor viruses

1982 • 833 citations

A new class of murine leukemia virus associated with development of spontaneous lymphomas.

1977 • 718 citations

Temporal fluctuations in HIV quasispecies in vivo are not reflected by sequential HIV isolations

1989 • 655 citations

Retroviral Recombination and Reverse Transcription

1990 • 596 citations

HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain

1990 • 589 citations

Origins and Evolutionary Relationships of Retroviruses

1989 • 581 citations

Genetic Variation in HTLV-III/LAV Over Time in Patients with AIDS or at Risk for AIDS

1986 • 570 citations

Structure, Replication, and Recombination of Retrovirus Genomes: Some Unifying Hypotheses

1979 • 529 citations

Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 gene

1991 • 525 citations

Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients

1986 • 513 citations

Genetic consequences of packaging two RNA genomes in one retroviral particle: pseudodiploidy and high rate of genetic recombination.

1990 • 477 citations

Genetic organization of a chimpanzee lentivirus related to HIV-1

1990 • 418 citations

"Spontaneous" Leukemia Developing in G3H Mice Following Inoculation, In Infancy, with AK-Emkemic.

1951 • 371 citations

Selection, recombination, and G----A hypermutation of human immunodeficiency virus type 1 genomes

1991 • 339 citations

"Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos.

1951 • 335 citations

Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas

1982 • 289 citations

Measurement of the mutation rates of animal viruses: influenza A virus and poliovirus type 1

1986 • 283 citations

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: substitutions, frameshifts, and hypermutations.

1990 • 282 citations

Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration.

1980 • 280 citations

Genetic variation in AIDS viruses

1986 • 279 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer.

1987 • 259 citations

Mutation Frequencies at Defined Single Codon Sites in Vesicular Stomatitis Virus and Poliovirus Can Be Increased Only Slightly by Chemical Mutagenesis

1990 • 256 citations

Genomic Diversity of Human T-Lymphotropic Virus Type III (HTLV-III)

1985 • 249 citations

The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate

1976 • 235 citations

The four classes of endogenous murine leukemia virus: structural relationships and potential for recombination

1987 • 230 citations

Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes.

1985 • 230 citations

Emergence of viruses resistant to neutralization by V3-specific antibodies in experimental human immunodeficiency virus type 1 IIIB infection of chimpanzees

1990 • 230 citations

Significance of premature stop codons in env of simian immunodeficiency virus

1989 • 220 citations

Identification of the principal neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain

1991 • 219 citations

Broad spectrum of in vivo forward mutations, hypermutations, and mutational hotspots in a retroviral shuttle vector after a single replication cycle: deletions and deletions with insertions.

1990 • 214 citations

Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.

1983 • 193 citations

Fidelity of two retroviral reverse transcriptases during DNA-dependent DNA synthesis in vitro.

1989 • 189 citations

Nucleotide sequence of a full-length human endogenous retroviral segment

1985 • 176 citations

Virological events leading to spontaneous AKR thymomas

1991 • 174 citations

Sequence comparisons of retroviral proteins: relative rates of change and general phylogeny.

1988 • 169 citations

Disease specificity of nondefective Friend and Moloney murine leukemia viruses is controlled by a small number of nucleotides

1987 • 164 citations

Determination of the rate of base-pair substitution and insertion mutations in retrovirus replication

1988 • 157 citations

Retroviral RNA Packaging: Sequence Requirements and Implications

1990 • 155 citations

Determinants for receptor interaction and cell killing on the avian retrovirus glycoprotein gp85

1986 • 152 citations

Interference grouping of murine leukemia viruses: A distinct receptor for the MCF-Recombinant viruses in mouse cells

1982 • 151 citations

The Mutation Rate and Variability of Eukaryotic Viruses: An Analytical Review

1987 • 151 citations

Evolution of human immunodeficiency virus type 1 nef and long terminal repeat sequences over 4 years in vivo and in vitro

1991 • 144 citations

The phylogenetic history of immunodeficiency viruses

1988 • 138 citations

New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors

1989 • 128 citations

Molecular basis of host range variation in avian retroviruses

1985 • 126 citations

Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design

1990 • 126 citations

Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion

1990 • 124 citations

Mechanism of Transduction by Retroviruses

1992 • 122 citations

The avian retrovirus env gene family: molecular analysis of host range and antigenic variants

1988 • 108 citations

Point mutations in the Moloney murine leukemia virus enhancer identify a lymphoid-specific viral core motif and 1,3-phorbol myristate acetate-inducible element

1990 • 99 citations

env Genes of avian retroviruses: Nucleotide sequence and molecular recombinants define host range determinants

1986 • 96 citations

Retroviral DNA H structures: Displacement-assimilation model of recombination

1982 • 94 citations

Generation of novel, biologically active Harvey sarcoma viruses via apparent illegitimate recombination

1981 • 87 citations

Determination of the mutation rate of a retrovirus

1988 • 87 citations

Differential transcription from the long terminal repeats of integrated avian leukosis virus DNA

1986 • 86 citations

Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions

1989 • 80 citations

Mutagenesis in vitro by DNA polymerase from an RNA tumour virus

1979 • 80 citations

Mechanism of leukemogenesis induced by mink cell focus-forming murine leukemia viruses

1991 • 78 citations

Influence of enhancer sequences on thymotropism and leukemogenicity of mink cell focus-forming viruses

1989 • 76 citations

Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization.

1991 • 73 citations

Genetic alterations of RNA leukemia viruses associated with the development of spontaneous thymic leukemia in AKR/J mice

1982 • 72 citations

The Next Computer Revolution

1987 • 67 citations

Nonecotropic murine leukemia viruses in BALB/c and NFS/N mice: characterization of the BALB/c Bxv-1 provirus and the single NFS endogenous xenotrope

1986 • 67 citations

VARIATION IN AVIAN RETROVIRUS GENOMES*

1980 • 67 citations

Efficient Packaging of Readthrough RNA in ALV: Implications for Oncogene Transduction

1987 • 63 citations

Induction of high-titer neutralizing antibodies, using hybrid human immunodeficiency virus V3-Ty viruslike particles in a clinically relevant adjuvant

1991 • 59 citations

Efficient autointegration of avian retrovirus DNA in vitro

1990 • 58 citations

Retrovirus Phylogeny and Evolution

1990 • 51 citations

Genetic Variation in Retroviruses

1990 • 44 citations

Role of recombinant ecotropic and polytropic viruses in the development of spontaneous thymic lymphomas in HRS/J mice

1984 • 40 citations

Polyadenylation at correct sites in genome RNA is not required for retrovirus replication or genome encapsidation

1989 • 39 citations

Reverse Transcription

1987 • 39 citations

Truncated gag-related proteins are produced by large deletion mutants of Rous sarcoma virus and form virus particles

1985 • 39 citations

Rearrangements in unintegrated retroviral DNA are complex and are the result of multiple genetic determinants

1990 • 33 citations

Evolutionary variants of Rous sarcoma virus: large deletion mutants do not result from homologous recombination

1985 • 25 citations

Origin of pathogenic determinants of recombinant murine leukemia viruses: analysis of Bxv-1-related xenotropic viruses from CWD mice

1990 • 23 citations

Chromosomal assignment of two endogenous ecotropic murine leukemia virus proviruses of the AKR/J mouse strain

1985 • 23 citations

Structure, origin, and transforming activity of feline leukemia virus-myc recombinant provirus FTT

1989 • 22 citations

Evidence that retroviral transduction is mediated by DNA not by RNA.

1990 • 21 citations

Biologic and molecular genetic characteristics of a unique MCF virus that is highly leukemogenic in ecotropic virus-negative mice

1989 • 19 citations

Identification of endogenous retroviral sequences as potential donors for recombinational repair of mutant retroviruses: Positions of crossover points

1987 • 17 citations

Retroviruses. strategies of replication

1991 • 17 citations

Sequence analysis of eukaryotic retroid proteins

1992 • 15 citations