An alternative function for human uncoupling protein 3: protection of mitochondria against accumulation of nonesterified fatty acids inside the mitochondrial matrix

THE BIOLOGY OF HUMAN STARVATION

1951 • 2,071 citations

Adaptations of skeletal muscle to endurance exercise and their metabolic consequences

1984 • 1,940 citations

Changes in Energy Expenditure Resulting from Altered Body Weight

1995 • 1,926 citations

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

1997 • 1,647 citations

Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

1997 • 1,067 citations

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

2000 • 770 citations

Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

1997 • 755 citations

Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice

2000 • 679 citations

Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

2000 • 615 citations

Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise

2000 • 564 citations

Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

1997 • 488 citations

Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

2000 • 391 citations

Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans.

1997 • 356 citations

Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

1998 • 308 citations

How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?

1999 • 306 citations

Elevated Free Fatty Acids Induce Uncoupling Protein 3 Expression in Muscle: A Potential Explanation for the Effect of Fasting

1998 • 305 citations

Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians

1998 • 290 citations

Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

1998 • 282 citations

The uncoupling proteins, a review

1998 • 269 citations

Linkage Between Markers in the Vicinity of the Uncoupling Protein 2 Gene and Resting Metabolic Rate in Humans

1997 • 227 citations

Fatty acid cycling mechanism and mitochondrial uncoupling proteins

1998 • 198 citations

Cloning of rat uncoupling protein‐3 and uncoupling protein‐2 cDNAs: their gene expression in rats fed high‐fat diet

1997 • 189 citations

Thermogenesis and Thyroid Function

1995 • 176 citations

UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase

2000 • 172 citations

Changes in fat oxidation in response to a high-fat diet

1997 • 169 citations

The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency

2001 • 133 citations

Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians.

1999 • 132 citations

Up-Regulation of Uncoupling Protein 3 (UCP3) mRNA by Exercise Training and Down-Regulation of UCP3 by Denervation in Skeletal Muscles

1998 • 130 citations

Triiodothyronine‐mediated upregulation of UCP2 and UCP3 mRNA expression in human skeletal muscle without coordinated induction of mitochondrial respiratory chain genes

2000 • 115 citations

Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses

1994 • 108 citations

Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect

2002 • 95 citations

Human Uncoupling Proteins and Obesity

1999 • 92 citations

Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation

1999 • 89 citations

Skeletal muscle UCP2 and UCP3 expression in trained and untrained male subjects

1999 • 86 citations

Fiber type dependent upregulation of human skeletal muscle UCP2 and UCP3 mRNA expression by high-fat diet

2001 • 85 citations

Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers

2001 • 82 citations

Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue.

2000 • 77 citations

Structure–Function Relationship in UCP1

1999 • 74 citations

Effects of Obesity and Stable Weight Reduction on UCP2 and UCP3 Gene Expression in Humans

1999 • 61 citations

The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat

2000 • 49 citations

The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects

2000 • 48 citations

Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β-oxidation

1999 • 48 citations

No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure

1998 • 40 citations

Protein expression of UCP3 differs between human type 1, type 2a, and type 2b fibers

2001 • 35 citations

Uncoupling protein-3 gene expression: reduced skeletal muscle mRNA in obese humans during pronounced weight loss

1999 • 28 citations

Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial β-oxidation

1999 • 20 citations

Gross efficiency responses to exercise conditioning in adult males of various ages

1991 • 20 citations

Effect of endurance training on gross energy expenditure during exercise.

1989 • 12 citations