Protective Role of an Endothelin-Converting Enzyme Inhibitor (FR901533) in Hepatic Ischemia/Reperfusion Injury

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

1991 • 663 citations

Molecular biology and biochemistry of the endothelins

1989 • 620 citations

The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances

1993 • 391 citations

Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion.

1994 • 374 citations

Endothelin-1 induces direct constriction of hepatic sinusoids

1994 • 300 citations

Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells

1998 • 230 citations

Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart.

1993 • 198 citations

Leukocytes contribute to hepatic ischemia/reperfusion injury via intercellular adhesion molecule-1-mediated venular adherence

1995 • 192 citations

Endothelin-1 is involved in the pathogenesis of ischemia/reperfusion liver injury by hepatic microcirculatory disturbances

1994 • 157 citations

Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells

1993 • 150 citations

Impact of leukocyte-endothelial cell interaction in hepatic ischemia-reperfusion injury

1994 • 142 citations

ET-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action

1994 • 142 citations

In vivo Fluorescence Microscopy for Quantitative Analysis of the Hepatic Microcirculation in Hamsters and Rats

1991 • 125 citations

Response of plasma and tissue endothelin-1 to liver ischemia and its implication in ischemia-reperfusion injury

1995 • 104 citations

POTENTIAL ROLES FOR ENDOTHELINS IN SYSTEMIC INFLAMMATORY RESPONSE SYNDROME WITH A PARTICULAR RELATIONSHIP TO CYTOKINES

1996 • 102 citations

Endothelin 1 induces leukocyte adhesion in submucosal venules of the rat small intestine

1998 • 94 citations

Effect of nitric oxide on iron-mediated oxidative stress in primary rat hepatocyte culture

1997 • 93 citations

Measurement of hepatic perfusion in rats by laser Doppler flowmetry

1992 • 91 citations

Reduction by superoxide dismutase of leukocyte-endothelial adherence after liver transplantation.

1992 • 89 citations

HEPATIC RELEASE OF ENDOTHELIN-1 AFTER WARM ISCHEMIA

1995 • 86 citations

Sinusoidal endothelial liver cells in vitro release endothelin — Augmentation by transforming growth factorβ and Kupffer cell-conditioned media

1991 • 79 citations

Differential impact of carolina rinse and university of wisconsin solutions on microcirculation, leukocyte adhesion, kupffer cell activity and biliary excretion after liver transplantation

1993 • 76 citations

Role of Microcirculatory Derangements in Manifestation of Portal Triad Cross-Clamping-Induced Hepatic Reperfusion Injury

1996 • 65 citations

Evaluation of Hepatic Microcirculation by In Vivo Microscopy

1999 • 48 citations

WS79089A, B and C, new endothelin converting enzyme inhibitors isolated from Streptosporangium roseum. No. 79089. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

1994 • 43 citations

Radioimmunological Determination of Endothelin Peptides in Human Plasma: A Methodological Approach

1994 • 39 citations

Comparative effects of crystalloid and small volume hypertonic hyperoncotic fluid resuscitation on hepatic microcirculation after hemorrhagic shock.

1993 • 38 citations

INHIBITION OF ENDOTHELIN-CONVERTING ENZYME ATTENUATES TRANSPLANT VASCULOPATHY AND REJECTION IN RAT CARDIAC ALLOGRAFTS1

1999 • 36 citations

Relationship between endothelin and thromboxane A2 in rat liver microcirculation

1992 • 35 citations

Dextran vs. hydroxyethylstarch in inhibition of postischemic leukocyte adherence in striated muscle.

1993 • 35 citations

Influence of hypoxia on hepatic and renal endothelin gene expression

1996 • 33 citations

Biological and Pharmacological Properties of Highly Selective New Endothelin Converting Enzyme Inhibitor WS79089B Isolated from Streptosporangium roseum No.79089.

1995 • 26 citations

Effects of mixed ETA and ETB-receptor antagonist (Ro-47-0203) on hepatic microcirculation after warm ischemia.

1997 • 25 citations

Endothelin-1 levels in portal venous blood in relation to hepatic tissue microcirculation disturbance and hepatic cell injury after ischemia/reperfusion

1997 • 17 citations

Important Role for Endothelins in Acute Hepatic Ischemia/Reperfusion Injury

2001 • 17 citations

Effect of the endothelin receptor antagonist bosentan on postischemic liver microcirculation.

1996 • 15 citations

Theory and Methods of Local Tissue-pO2 Monitoring in Experimental Angiology

1987 • 13 citations

Effect of the Endothelin Receptor Antagonist Bosentan on Postischemic Oxygen Supply of the Liver

1996 • 12 citations