Long-Term Effects of Stimulant Medications on the Brain: Possible Relevance to the Treatment of Attention Deficit Hyperactivity Disorder

A 14-Month Randomized Clinical Trial of Treatment Strategies for Attention-Deficit/Hyperactivity Disorder

1999 • 3,305 citations

Estimating Causal Effects from Large Data Sets Using Propensity Scores

1997 • 2,867 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants

1997 • 1,234 citations

Quantitative Brain Magnetic Resonance Imaging in Attention-Deficit Hyperactivity Disorder

1996 • 1,179 citations

Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

1998 • 1,095 citations

Hyperactive Boys Almost Grown Up

1985 • 996 citations

Pharmacotherapy of Attention-Deficit Hyperactivity Disorder across the Life Cycle

1996 • 846 citations

Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study

1998 • 844 citations

Adult Psychiatric Status of Hyperactive Boys Grown Up

1998 • 775 citations

Volumetric MRI analysis comparing subjects having attention-deficit hyperactivity disorder with normal controls

1997 • 746 citations

Persistent Structural Modifications in Nucleus Accumbens and Prefrontal Cortex Neurons Produced by Previous Experience with Amphetamine

1997 • 712 citations

Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration

1998 • 686 citations

Hyperactive Boys Almost Grown Up

1991 • 559 citations

Phenobarbital for Febrile Seizures — Effects on Intelligence and on Seizure Recurrence

1990 • 551 citations

Behavioral validation of the spontaneously hypertensive rat (SHR) as an animal model of attention-deficit/hyperactivity disorder (AD/HD)

2000 • 510 citations

Pharmacotherapy of Attention-deficit/Hyperactivity Disorder Reduces Risk for Substance Use Disorder

1999 • 488 citations

Is ADHD a Risk Factor for Psychoactive Substance Use Disorders? Findings From a Four-Year Prospective Follow-up Study

1997 • 487 citations

Prospective Study of Tobacco Smoking and Substance Dependencies Among Samples of ADHD and Non-ADHD Participants

1998 • 468 citations

Effects of ADHD, Conduct Disorder, and Gender on Substance Use and Abuse in Adolescence

1999 • 419 citations

Treatment of Attention-Deficit–Hyperactivity Disorder

1999 • 409 citations

Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors.

1999 • 403 citations

Long-term Stimulant Treatment of Children With Attention-Deficit Hyperactivity Disorder Symptoms

1997 • 347 citations

Postmarketing Surveillance and Adverse Drug Reactions

1999 • 342 citations

National Institutes of Health Consensus Development Conference Statement: Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD)

2000 • 321 citations

A Naturalistic Assessment of the Motor Activity of Hyperactive Boys

1983 • 302 citations

Resolved: Mania Is Mistaken for ADHD in Prepubertal Children

1998 • 294 citations

A Single Exposure to Amphetamine Is Sufficient to Induce Long-Term Behavioral, Neuroendocrine, and Neurochemical Sensitization in Rats

1999 • 286 citations

Stimulant Medications

1999 • 259 citations

National Institute of Mental Health Collaborative Multimodal Treatment Study of Children With ADHD (the MTA)

1997 • 241 citations

Further evidence that amphetamines produce long-lasting dopamine neurochemical deficits by destroying dopamine nerve fibers

1984 • 216 citations

Acute tolerance to methylphenidate in the treatment of attention deficit hyperactivity disorder in children*

1999 • 211 citations

Methylphenidate and Children With Attention Deficit Disorder

1985 • 208 citations

Methylphenidate and cocaine have a similar in vivo potency to block dopamine transporters in the human brain

1999 • 185 citations

Long-Lasting Psychotomimetic Consequences of Repeated Low-Dose Amphetamine Exposure in Rhesus Monkeys

1999 • 185 citations

Psychotherapeutic Medication Patterns for Youths With Attention-Deficit/Hyperactivity Disorder

1999 • 168 citations

The development of sensitization to the psychomotor stimulant effects of amphetamine is enhanced in a novel environment

1995 • 164 citations

Methylphenidate and Growth in Hyperactive Children

1988 • 157 citations

Hyperactive Boys Almost Grown Up

1988 • 156 citations

A Lasting Vulnerability to Psychosis in Patients with Previous Methamphetamine Psychosis

1992 • 155 citations

Progressive behavioral response to repeated d-amphetamine challenge: further evidence for sensitization in humans

1998 • 155 citations

Psychomotor stimulants, social deprivation and play in juvenile rats

1982 • 130 citations

Sensitization and Tolerance in Psychostimulant Self-Administration

1997 • 125 citations

A Naturalistic Assessment of the Motor Activity of Hyperactive Boys

1983 • 124 citations

Diurnal differences in sensitization to methylphenidate

2000 • 105 citations

Long-lasting effects of escalating doses of d-amphetamine on brain monoamines, amphetamine-induced stereotyped behavior and spontaneous nocturnal locomotion

1987 • 101 citations

Stimulant Treatment in Young Boys with Symptoms Suggesting Childhood Mania: A Report from a Longitudinal Study

2000 • 96 citations

Childhood Inattention-Overactivity, Aggression, and Stimulant Medication History as Predictors of Young Adult Outcomes

1999 • 88 citations

Repeated methylphenidate treatment induces behavioral sensitization and decreases protein kinase A and dopamine-stimulated adenylyl cyclase activity in the dorsal striatum

1998 • 81 citations

Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain

1999 • 74 citations

Effects of repeated methylphenidate treatment in the young rat: Sensitization of both locomotor activity and stereotyped sniffing.

1999 • 72 citations

A comparison of the motor-activating effects of acute and chronic exposure to amphetamine and methylphenidate

1993 • 69 citations

Sensitization to cocaine and dopamine autoreceptor subsensitivity in the nucleus accumbens

1995 • 68 citations

Subjective and behavioral effects of repeated d-amphetamine in humans

1999 • 61 citations

Behavioral Changes and [123I]IBZM Equilibrium SPECT Measurement of Amphetamine-Induced Dopamine Release in Rhesus Monkeys Exposed to Subchronic Amphetamine

2000 • 53 citations

Susceptibility to Amphetamine-Induced Locomotor Sensitization Is Modulated by Environmental Stimuli

1999 • 53 citations

Sensitization of mice to methylphenidate

1982 • 52 citations

Effects of intravenous dextroamphetamine on brain metabolism in adults with attention-deficit hyperactivity disorder (ADHD). Preliminary findings.

1994 • 50 citations

Body Growth and Cardiovascular Function after Extended Treatment (1.75 Years) with Methylphenidate in Boys with Attention-Deficit Hyperactivity Disorder

1995 • 38 citations

Intravenous Dextroamphetamine and Brain Glucose Metabolism

1997 • 37 citations

Effects of repeated methylphenidate treatment in the young rat: Sensitization of both locomotor activity and stereotyped sniffing.

1999 • 19 citations

Deleted Work

1955 • 0 citations