Lymphomas differ in their dependence on Epstein-Barr virus

Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function

2005 • 1,751 citations

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

1982 • 1,424 citations

Transfer of a functional human immune system to mice with severe combined immunodeficiency

1988 • 1,248 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy

2002 • 923 citations

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

2000 • 830 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

2009 • 755 citations

Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.

1987 • 735 citations

Programmed cell death: alive and well in the new millennium

2001 • 663 citations

Mechanisms of tamoxifen resistance

2004 • 613 citations

Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein–Barr virus nuclear antigen 1

1997 • 549 citations

Epstein-Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state

1994 • 499 citations

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27

1999 • 497 citations

Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1,which simulates an activated CD40 receptor

1998 • 480 citations

The Expression Pattern of Epstein-Barr Virus Latent Genes In Vivo Is Dependent upon the Differentiation Stage of the Infected B Cell

2000 • 462 citations

Classification of lymphoid neoplasms: the microscope as a tool for disease discovery

2008 • 372 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2rγ^nullhumanized mice

2010 • 336 citations

Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell

1997 • 315 citations

Isolation of Epstein-Barr virus (EBV)-negative cell clones from the EBV-positive Burkitt's lymphoma (BL) line Akata: malignant phenotypes of BL cells are dependent on EBV

1994 • 286 citations

Epstein-Barr virus provides a survival factor to Burkitt's lymphomas

2003 • 263 citations

Human CD8 + T Cell Responses to EBV EBNA1: HLA Class I Presentation of the (Gly-Ala)–Containing Protein Requires Exogenous Processing

1997 • 261 citations

B-cell proliferation and induction of early G1-regulating proteins by Epstein-Barr virus mutants conditional for EBNA2.

1995 • 255 citations

Time-Sensitive Reversal of Hyperplasia in Transgenic Mice Expressing SV40 T Antigen

1996 • 240 citations

Epstein–Barr virus–associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2

2002 • 223 citations

Action of Myc in vivo — proliferation and apoptosis

2000 • 193 citations

Two Epstein–Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma

2007 • 182 citations

The coupling of synthesis and partitioning of EBV's plasmid replicon is revealed in live cells

2007 • 178 citations

Epstein-Barr Virus (EBV) in Endemic Burkitt's Lymphoma: Molecular Analysis of Primary Tumor Tissue

1998 • 176 citations

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation

2004 • 168 citations

An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link

2009 • 162 citations

Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma

2003 • 162 citations

Epstein–Barr virus infection in humans: from harmless to life endangering virus–lymphocyte interactions

2007 • 154 citations

Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma

1995 • 147 citations

Transcriptional activation by EBV nuclear antigen 1 is essential for the expression of EBV's transforming genes

2006 • 140 citations

The microRNAs of Epstein–Barr Virus are expressed at dramatically differing levels among cell lines

2009 • 136 citations

Epstein-Barr Virus DNA Recombination and Loss in Sporadic Burkitt's Lymphoma

1996 • 119 citations

Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival.

1996 • 118 citations

The plasmid replicon of Epstein–Barr virus: Mechanistic insights into efficient, licensed, extrachromosomal replication in human cells

2007 • 110 citations

Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) Gene Deletion Is Consistently Linked with EBNA3A, -3B, and -3C Expression in Burkitt's Lymphoma Cells and with Increased Resistance to Apoptosis

2005 • 109 citations

The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis

2007 • 106 citations

Burkitt Lymphoma: Revisiting the Pathogenesis of a Virus-Associated Malignancy

2007 • 104 citations

Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus

1997 • 94 citations

Posttransplantation Lymphoproliferative Disorders

2003 • 92 citations

The Epstein–Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

2009 • 81 citations

Overexpression of Mxi1 inhibits the induction of the human ornithine decarboxylase gene by the Myc/Max protein complex.

1996 • 38 citations

The Affinity of EBNA1 for Its Origin of DNA Synthesis Is a Determinant of the Origin's Replicative Efficiency

2008 • 23 citations