The adipose organ

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Obesity is associated with macrophage accumulation in adipose tissue

2003 • 8,349 citations

Inflammation and metabolic disorders

2006 • 8,000 citations

Brown Adipose Tissue: Function and Physiological Significance

2004 • 5,925 citations

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

2003 • 5,744 citations

Adipose Tissue as an Endocrine Organ

2004 • 5,220 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

2005 • 2,337 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

Adipokines: inflammation and the pleiotropic role of white adipose tissue

2004 • 2,127 citations

A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

1996 • 2,048 citations

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

1999 • 1,959 citations

Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators

2003 • 1,789 citations

Adipose Tissue as an Endocrine Organ

2000 • 1,568 citations

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

1997 • 1,334 citations

Reduction of Macrophage Infiltration and Chemoattractant Gene Expression Changes in White Adipose Tissue of Morbidly Obese Subjects After Surgery-Induced Weight Loss

2005 • 1,127 citations

Critical periods in childhood for the development of obesity

1994 • 1,077 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart

2005 • 925 citations

Echocardiographic Epicardial Adipose Tissue Is Related to Anthropometric and Clinical Parameters of Metabolic Syndrome: A New Indicator of Cardiovascular Risk

2003 • 813 citations

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

2002 • 768 citations

The biology of white adipocyte proliferation

2001 • 681 citations

Gender differences in fat metabolism

2001 • 640 citations

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

1992 • 630 citations

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

1998 • 624 citations

Adipose Tissue-Derived Factors: Impact on Health and Disease

2006 • 616 citations

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

2000 • 569 citations

FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

2001 • 549 citations

Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance

2000 • 543 citations

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

1995 • 539 citations

Techniques for the measurement of visceral fat: a practical guide.

1993 • 539 citations

Brown adipose tissue: a factor to consider in symmetrical tracer uptake in the neck and upper chest region

2002 • 500 citations

Diet-induced adipocyte number increase in adult rats: a new model of obesity.

1978 • 498 citations

Estrogen Regulation of Adiposity and Fuel Partitioning

2005 • 486 citations

Adipose Tissue Quantification by Imaging Methods: A Proposed Classification

2003 • 484 citations

Visceral Obesity: A “Civilization Syndrome”

1993 • 479 citations

Adipose tissue in human infancy and childhood: An evolutionary perspective

1998 • 468 citations

Periadventitial fat releases a vascular relaxing factor

2002 • 457 citations

Insulin Resistance in Morbid Obesity

2002 • 435 citations

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

1996 • 406 citations

Regulation of Adipose Cell Number in Man

1997 • 405 citations

How cells change their phenotype

2002 • 403 citations

An atlas of mouse mammary gland development.

2000 • 398 citations

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

2001 • 388 citations

An Essential Regulator of Adipogenesis and Modulator of Fat Cell Function: PPARγ

1999 • 384 citations

THE DIFFERENTIATION OF WHITE ADIPOSE CELLS

1963 • 382 citations

Production of Chemokines by Perivascular Adipose Tissue

2005 • 375 citations

Selective parasympathetic innervation of subcutaneous and intra-abdominal fat — functional implications

2002 • 368 citations

Brown adipose tissue in the parametrial fat pad of the mouse

1984 • 355 citations

Adipose tissue in the mammalian heart and pericardium: Structure, foetal development and biochemical properties

1989 • 349 citations

Estimation of adipose tissue mass by magnetic resonance imaging: validation against dissection in human cadavers.

1994 • 344 citations

Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue

2005 • 343 citations

The occurrence of brown adipose tissue in outdoor workers

1981 • 325 citations

Adipose tissue distribution and function.

1991 • 323 citations

Effect of age, sex, and site on the cellularity of the adipose tissue in mice and rats rendered obese by a high-fat diet

1972 • 312 citations

Sarcopenia and increased adipose tissue infiltration of muscle in elderly African American women

2004 • 311 citations

Relation between epicardial adipose tissue and left ventricular mass

2004 • 309 citations

Magnetic resonance imaging of total body fat

1998 • 300 citations

The ventricular epicardial fat is related to the myocardial mass in normal, ischemic and hypertrophic hearts

2004 • 289 citations

The uncoupling protein ucp: A membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue

1991 • 287 citations

Visceral fat accumulation: the missing link between psychosocial factors and cardiovascular disease?

1991 • 284 citations

Metabolic and cellular plasticity in white adipose tissue I: effects of β₃-adrenergic receptor activation

2005 • 283 citations

A Central Thermogenic-like Mechanism in Feeding Regulation: An Interplay between Arcuate Nucleus T3 and UCP2

2007 • 279 citations

Cellularity of adipose depots in six strains of genetically obese mice

1972 • 273 citations

Strain-Specific Response toβ₃-Adrenergic Receptor Agonist Treatment of Diet-Induced Obesity in Mice¹

1997 • 260 citations

Genetic Determinants of Energy Expenditure and Insulin Resistance in Diet-Induced Obesity in Mice

2004 • 254 citations

Rosiglitazone promotes development of a novel adipocyte population from bone marrow–derived circulating progenitor cells

2006 • 254 citations

Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats

1997 • 246 citations

BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

1997 • 234 citations

The Brown Fat Cell

1982 • 233 citations

Immunohistochemical Localization of Leptin and Uncoupling Protein in White and Brown Adipose Tissue¹

1997 • 218 citations

The adipose organ: morphological perspectives of adipose tissues

2001 • 213 citations

Adipocyte differentiation and transdifferentiation: Plasticity of the adipose organ

2002 • 208 citations

Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults

2004 • 200 citations

Metabolism of mammary, abdominal, and femoral adipocytes in women before and after menopause

1986 • 199 citations

Molecular studies of the uncoupling protein

1991 • 197 citations

Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist

1997 • 196 citations

Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans

1997 • 194 citations

Effect of a 28-d treatment with L-796568, a novel β3-adrenergic receptor agonist, on energy expenditure and body composition in obese men

2002 • 175 citations

Convertible adipose tissue in mice

1991 • 174 citations

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ER ^T2 ) in adipocytes

2000 • 171 citations

Necrosis of the Anterior Pituitary and Zona Glomerulosa of the Adrenal

1964 • 170 citations

White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation

2006 • 164 citations

Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum

1998 • 162 citations

Exclusive occurrence of thermogenin antigen in brown adipose tissue

1982 • 161 citations

The role of brown adipose tissue in human obesity

2006 • 157 citations

Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland

2004 • 152 citations

Body fat and adipose tissue cellularity in infants: A longitudinal study

1977 • 151 citations

Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance

2003 • 147 citations

β₃‐Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat

2003 • 147 citations

Pre-medication to block [18F]FDG uptake in the brown adipose tissue of pediatric and adolescent patients

2005 • 141 citations

Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans.

1992 • 141 citations

Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs.

1991 • 137 citations

A developmental atlas of rat mammary gland histology.

2000 • 131 citations

Intra-abdominal adipose tissue in young children.

1995 • 129 citations

Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

2000 • 126 citations

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

1972 • 122 citations

Tyrosine hydroxylase, neuropeptide Y, substance P, calcitonin gene-related peptide and vasoactive intestinal peptide in nerves of rat periovarian adipose tissue: an immunohistochemical and ultrastructural investigation

1996 • 119 citations

[Epicardial fatty tissue of the right ventricle--morphology, morphometry and functional significance].

1989 • 114 citations

Visceral adipose tissue impairs insulin secretion and insulin sensitivity but not energy expenditure in obesity

1997 • 107 citations

Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes

2000 • 106 citations

Lipid‐depleted white adipose cells: An electron microscope study

1963 • 104 citations

Fasting inhibits natriuretic peptides clearance receptor expression in rat adipose tissue

1995 • 101 citations

Brown adipose tissue

1986 • 101 citations

Leptin Selectively Augments Thymopoiesis in Leptin Deficiency and Lipopolysaccharide-Induced Thymic Atrophy

2006 • 98 citations

The changes with age of the anatomical distribution of fat

1982 • 98 citations

Expression of Human α2-Adrenergic Receptors in Adipose Tissue of β3-Adrenergic Receptor-deficient Mice Promotes Diet-induced Obesity

2000 • 96 citations

TH-, NPY-, SP-, and CGRP-immunoreactive nerves in interscapular brown adipose tissue of adult rats acclimated at different temperatures: an immunohistochemical study.

1998 • 86 citations

Selective ablation of retinoid X receptor α in hepatocytes impairs their lifespan and regenerative capacity

2001 • 85 citations

Spontaneous sweat secretion in calcium-free strontium medium

1982 • 84 citations

Regional-dependent Increase of Sympathetic Innervation in Rat White Adipose Tissue during Prolonged Fasting

2005 • 84 citations

Immunohistochemical identification of the β3-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine

2002 • 79 citations

Fibronectins and basal lamina molecules expression in human subcutaneous white adipose tissue.

1998 • 78 citations

Visceral fat loss evaluated by total body magnetic resonance imaging in obese women operated with laparascopic adjustable silicone gastric banding

2000 • 78 citations

Rosiglitazone modifies the adipogenic potential of human muscle satellite cells

2006 • 75 citations

Lipolysis in Intraabdorninal Adipose Tissues of Obese Women and Men

1993 • 74 citations

Leptin and UCP1 Genes are Reciprocally Regulated in Brown Adipose Tissue

1998 • 72 citations

The Regulation and Activation of Ciliary Neurotrophic Factor Signaling Proteins in Adipocytes

2003 • 71 citations

Immunohistochemical detection of human brown adipose tissue uncoupling protein in an autopsy series.

1993 • 69 citations

Lipolysis and lamellar structures in white adipose tissue of young rats: lipid movement in membranes

1981 • 65 citations

The Anatomy of Adipose Tissue in Captive Macaca Monkeys and Its Implications for Human Biology

1987 • 63 citations

Ultrastructural Immunolocalization of Leptin Receptor in Mouse Brain

1998 • 59 citations

Localization of leptin receptor splice variants in mouse peripheral tissues by immunohistochemistry

1998 • 59 citations

Immunohistochemical Localization of Leptin and Uncoupling Protein in White and Brown Adipose Tissue

1997 • 58 citations

Sensory nerves affect the recruitment and differentiation of rat periovarian brown adipocytes during cold acclimation

1998 • 57 citations

Presence and Distribution of Cholinergic Nerves in Rat Mediastinal Brown Adipose Tissue

2004 • 57 citations

Sampling the intramyocellular triglycerides from skeletal muscle

2001 • 55 citations

Anatomy of the adipose organ

2000 • 54 citations

Dual Regulatory Effects of Orexins on Sympathetic Nerve Activity Innervating Brown Adipose Tissue in Rats

2005 • 52 citations

Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor α‐methyl‐p‐tyrosine

1998 • 50 citations

Immunohistochemical, ultrastructural and morphometric evidence for brown adipose tissue recruitment due to cold acclimation in old rats.

1995 • 43 citations

Comparison of adipose tissue changes following administration of rosiglitazone in the dog and rat

2001 • 43 citations

Immunoelectron microscopical identification of the uncoupling protein in brown adipose tissue mitochondria

1989 • 42 citations

Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis

2002 • 38 citations

S-100 Protein in Rat Brown Adipose Tissue under Different Functional Conditions: A Morphological, Immunocytochemical, and Immunochemical Study

1993 • 38 citations

Size and number of adipocytes and measures of body fat in boys and girls 10 to 18 years of age

1981 • 36 citations

Rat interscapular brown adipose tissue at different ages: a morphometric study.

1991 • 35 citations

Thymus Uncoupling Protein 1 Is Exclusive to Typical Brown Adipocytes and Is Not Found in Thymocytes

2006 • 33 citations

Treatment with CL 316,243, a β3-adrenoceptor agonist, reduces serum leptin in rats with diet- or aging-associated obesity, but not in Zucker rats with genetic (fa/fa) obesity

1997 • 31 citations

Mediastinal hibernoma: a case report

2004 • 30 citations

Development of a Rapid and Efficient Magnetic Resonance Imaging Technique for Analysis of Body Fat Distribution

1996 • 29 citations

Human brown adipose cells in culture

1985 • 29 citations

Brown adipose tissue thermogenesis in neonatal and cold-adapted animals

1986 • 24 citations

Isolation and ultrastructural features of brown adipocytes in culture.

1986 • 24 citations

Effects of diet and environment on adipocyte development.

1981 • 21 citations

Leptin and UCP1 Genes are Reciprocally Regulated in Brown Adipose Tissue

1998 • 16 citations

Brown Adipose Tissue: A Scanning Electron Microscopic Study of Tissue and Cultured Adipocytes

1987 • 15 citations

In-vivo quantitative hydrolipidic map of perirenal adipose tissue by chemical shift imaging at 4.7 Tesla

2001 • 15 citations

Effects of noradrenaline exposure on rat brown adipocytes in cultures. An ultrastructural study

1987 • 13 citations

Quantitative evaluations of gap junctions in old rat brown adipose tissue after cold acclimation: A freeze-fracture and ultra-structural study

1994 • 12 citations

The adipose organ: endocrine aspects and insights from transgenic models.

2001 • 12 citations