Role of prostaglandins in the defense of the gastric mucosa

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Advances in Prostaglandin and Thromboxane Research

1976 • 840 citations

The chemical structure of prostaglandin X (prostacyclin)

1976 • 729 citations

The importance of phospholipase-A2 in prostaglandin biosynthesis

1976 • 647 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

1976 • 606 citations

Advances in prostaglandin and thromboxane research

1976 • 602 citations

Prostaglandin Endoperoxides. A New Concept Concerning the Mode of Action and Release of Prostaglandins

1974 • 495 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Gastric Mucosal Injury by Fatty and Acetylsalicylic Acids

1964 • 446 citations

Comparison of the effects of prostacyclin (PGI2), prostaglandin E1 and D2 on platelet aggregation in different species

1978 • 339 citations

Antisecretory, antiulcer, cytoprotective and diarrheogenic properties of prostaglandins.

1976 • 330 citations

A radioimmunoassay for 6-keto- prostaglandin F1α

1978 • 319 citations

: A selective inhibitor of thromboxane synthetase

1977 • 303 citations

Effect of Prostaglandin E1 on Gastric Secretion and Ulcer Formation in the Rat

1968 • 285 citations

Inhibition of gastric secretion by prostaglandins

1967 • 285 citations

Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine.

1979 • 279 citations

MECHANISMS UNDERLYING GASTRIC MUCOSAL DAMAGE INDUCED BY INDOMETHACIN AND BILE‐SALTS, AND THE ACTIONS OF PROSTAGLANDINS

1977 • 272 citations

Topical Aspirin Plus HCl Gastric Lesions in the Rat

1979 • 258 citations

PROSTAGLANDIN SYNTHETASE INHIBITORS

1979 • 220 citations

Prostaglandin cytoprotection of gastric mucosa

1978 • 199 citations

Effect of nerve stimulation on prostaglandin formation and release from the rat stomach

1967 • 194 citations

Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins

1978 • 188 citations

INVESTIGATION OF THE VASODILATOR AND ANTISECRETORY ROLE OF PROSTAGLANDINS IN THE RAT GASTRIC MUCOSA BY USE OF NON‐STEROIDAL ANTI‐INFLAMMATORY DRUGS

1975 • 182 citations

Release of Prostaglandin E1 from the Rat Stomach

1967 • 173 citations

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

1973 • 163 citations

Prostaglandin and cimetidine inhibit the formation of ulcers produced by parenteral salicylates

1978 • 154 citations

Actions of prostacyclin (PGI2) and its product, 6-oxo-PGF1α on the rat gastric mucosa in vivo and in vitro

1978 • 154 citations

Stimulation of Alkaline Secretion in Amphibian-Isolated Gastric Mucosa by 16,16-Dimethyl PGE2 and PGF2α

1979 • 135 citations

Synthesis of 6-keto-PGF1α by ram seminal vesicle microsomes

1977 • 128 citations

OCCURRENCE OF PROSTAGLANDIN E₂ IN THE HUMAN STOMACH, AND A STUDY OF ITS EFFECTS ON HUMAN ISOLATED GASTRIC MUSCLE

1968 • 128 citations

Inhibition of Gastric Secretion in Man by Prostaglandin A1

1971 • 127 citations

Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins

1976 • 96 citations

The effect of several ulcerogenic drugs on the canine gastric mucosal barrier.

1972 • 95 citations

Protective Effect of Prostaglandin E1 (PGE1) on Lysosomal Enzyme Release in Serotonin-Induced Gastric Ulceration

1973 • 93 citations

Effects of prostaglandins on the stomach and the intestine

1974 • 81 citations

Effect of aspirin, bile salt, and ethanol on canine gastric mucosal blood flow.

1975 • 81 citations

Gastric mucosal blood flow during pentagastrin‐ and histamine‐stimulated acid secretion in the rat

1973 • 63 citations

Prostaglandins and Thromboxanes

1978 • 59 citations

Inhibition of indomethacin-induced gastric ulceration in the rat by perorally-administered synthetic and natural prostaglandin analogues

1974 • 58 citations

Effects of an Orally Administered Prostaglandin Analogue (16,16-Dimethyl Prostaglandin E2) on Human Gastric Secretion

1975 • 56 citations

POTENCY AND SELECTIVITY OF METHYL ANALOGUES OF PROSTAGLANDIN E₂ ON RAT GASTROINTESTINAL FUNCTION

1975 • 51 citations

Effects of oral administration of PGE2 on gastric secretion and experimental peptic ulcerations

1973 • 51 citations

Potential endogenous inhibitor of prostaglandin synthetase in plasma: failure to inhibit cyclo-oxygenase in platelets and the gastric mucosa

1978 • 48 citations

Protection by histamine receptor antagonists and prostaglandin against gastric mucosal barrier disruption in the rat.

1979 • 48 citations

Pathophysiology of stress ulcer and its prevention

1975 • 46 citations

Bile-induced acute erosive gastritis

1976 • 42 citations

Protection by histamine receptor antagonists and prostaglandin against gastric mucosal barrier disruption in the rat

1979 • 41 citations

Gastric Antisecretory Effect of 15(R)-15-Methyl PGE2, Methyl Ester and of 15(S)-15-Methyl PGE2, Methyl Ester

1975 • 37 citations

Synthesis of thromboxane B2 and prostaglandins by bovine gastric mucosal microsomes

1977 • 37 citations

The effect of orally and intravenously administered prostaglandin 16:16 dimethyl E2 methyl ester on human gastric acid secretion

1973 • 36 citations

Prostaglandin E2 prevents aspirin and indomethacin damage to human gastric mucosa.

1976 • 36 citations

The effects of anti-ulcer agents on indomethacin-induced gastric ulceration in the rat.

1971 • 35 citations

Prostaglandin inhibition of histamine-stimulated aminopyrine uptake and cyclic AMP generation by isolated canine parietal cells

1978 • 31 citations

Inhibition of Stimulated Gastric Secretion by an Orally Administered Prostaglandin Capsule

1976 • 29 citations

Effect of prostaglandin 15(R) 15 methyl-E2 methyl ester on aspirin and taurocholic acid-induced gastric mucosal haemorrhage in rats.

1976 • 28 citations

The effect of locally administered prostaglandin 15 (R) 15 methyl-E2 methyl ester on gastric ulcer formation in the shay rat preparation

1974 • 28 citations

Prostaglandins VIII: A proposed role for PGE2 in the genesis of stress-induced gastric ulcers

1974 • 22 citations

The relative activity of prostacyclin (PGI2) and a stable analogue 6β-PGI1 on the gastrointestinal and cardiovascular systems

1978 • 20 citations

The effects of a prostaglandin endoperoxide analogue on canine gastric acid and mucus secretion

1979 • 17 citations

Effect of synthetic 15-methyl analog of prostaglandin E2 on gastric secretion and peptic ulcer formation.

1974 • 11 citations

Gastric antisecretory and cardiovascular actions of a stable 16-phenoxy prostacyclin analog in the dog.

1980 • 6 citations

Antisecretory Prostaglandins and Gastric Mucosal Erosions in the Rat

1977 • 1 citations