Identification of Residues Important for Agonist Recognition and Activation in GPR40

Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes

2006 • 5,962 citations

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

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Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

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Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

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[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors

1995 • 2,811 citations

The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

2003 • 2,083 citations

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

2003 • 1,469 citations

The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids

2003 • 1,050 citations

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin

2006 • 439 citations

The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

2005 • 406 citations

Fatty Acid Signaling in the β-Cell and Insulin Secretion

2006 • 388 citations

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

2006 • 383 citations

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo

2007 • 255 citations

A chemogenomic analysis of the transmembrane binding cavity of human G‐protein‐coupled receptors

2005 • 223 citations

Role of GPR40 in fatty acid action on the β cell line INS-1E

2005 • 220 citations

A Cluster of Four Novel Human G Protein-Coupled Receptor Genes Occurring in Close Proximity to CD22 Gene on Chromosome 19q13.1

1997 • 203 citations

A Family of Fatty Acid Binding Receptors

2005 • 144 citations

Reduction in Voltage-Gated K+ Currents in Primary Cultured Rat Pancreatic β-Cells by Linoleic Acids

2005 • 125 citations

Synthesis and activity of small molecule GPR40 agonists

2006 • 110 citations

A Low Molecular Weight Agonist Signals by Binding to the Transmembrane Domain of Thyroid-stimulating Hormone Receptor (TSHR) and Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR)

2006 • 96 citations

Synthesis and Biological Evaluation of 3-Aryl-3-(4-phenoxy)-propionic Acid as a Novel Series of G Protein-Coupled Receptor 40 Agonists

2007 • 91 citations

Bidirectional, Iterative Approach to the Structural Delineation of the Functional “Chemoprint” in GPR40 for Agonist Recognition

2007 • 86 citations

Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5′-O-(3-[³⁵S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist

2007 • 79 citations

Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor

2007 • 70 citations

The ins and outs of fatty acids on the pancreatic β cell

2003 • 46 citations