Leishmania-specific T cells expressing interferon-gamma (IFN-γ) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

New Perspectives on a Subclinical Form of Visceral Leishmaniasis

1986 • 494 citations

Th1 and Th2 subsets: paradigms lost?

1995 • 482 citations

Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies

1995 • 473 citations

Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

1993 • 445 citations

In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.

1993 • 345 citations

An interleukin 4 (IL-4)-independent pathway for CD4⁺T cell IL-4 production is revealed in IL-4 receptor-deficient mice

1997 • 334 citations

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

1985 • 321 citations

Th1-Th2: Reliable paradigm or dangerous dogma?

1997 • 312 citations

Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.

1996 • 311 citations

Two Cases of Type E Infant Botulism Caused by Neurotoxigenic Clostridium butyricum in Italy

1986 • 262 citations

Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis.

1991 • 231 citations

IL-12 enhances Th1-type responses in human Leishmania donovani infections.

1995 • 208 citations

Potential role for interleukin-10 in the immunosuppression associated with kala azar.

1993 • 131 citations

IL-12 induces human T cells secreting IL-10 with IFN-gamma.

1996 • 121 citations

The contrasting roles of CD4+ T cells in intracellular infections in humans: leishmaniasis as an example

1996 • 104 citations

Identification of a T cell subset capable of both IFN-gamma and IL-10 secretion in patients with chronic Borrelia burgdorferi infection.

1998 • 92 citations

Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis

1994 • 83 citations

Identification of a T Cell Subset Capable of both IFN-γ and IL-10 Secretion in Patients with ChronicBorrelia burgdorferiInfection

1998 • 77 citations

In vivo and in vitro cytokine profiles and mononuclear cell subsets in sicilian patients with active visceral leishmaniasis

1995 • 74 citations

Measurement of intracellular cytokines

1996 • 69 citations

Recognition of Leishmania antigens by T lymphocytes from nonexposed individuals

1992 • 67 citations

Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Thl-like response to lipophosphoglycan- associated protein in cells from cured visceral leishmaniasis patients

1994 • 61 citations

Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections

1995 • 44 citations

A new portable device for automatic controlled-gradient cryopreservation of blood mononuclear cells

1993 • 37 citations

Interleukin‐4 and Interferon‐Gamma Production by Leishmania Stimulated Peripheral Blood Mononuclear Cells from Nonexposed Individuals

1995 • 33 citations

Interferon‐γ Production by Human T Cells and Natural Killer Cells In Vitro in Response to Antigens from the Two Intracellular Pathogens Mycobacterium tuberculosis and Leishmania major

1997 • 26 citations

Production of interferon-gamma and interleukin-4 by human T cells recognizing Leishmania lipophosphoglycan-associated protein

1993 • 19 citations

Interferon‐γ and interleukin‐4 production by human T cells recognizing Leishmania donovani antigens separated by SDS‐PAGE

1995 • 9 citations