Cell biology of vascular hypertrophy in systemic hypertension

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Reductions in Arterial Diameter Produced by Chronic Decreases in Blood Flow Are Endothelium-Dependent

1986 • 1,106 citations

Suppression by heparin of smooth muscle cell proliferation in injured arteries

1977 • 798 citations

Cyclic Stretching Stimulates Synthesis of Matrix Components by Arterial Smooth Muscle Cells in Vitro

1976 • 701 citations

Capillary endothelial cell cultures: phenotypic modulation by matrix components.

1983 • 611 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers.

1978 • 461 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

Regulation of myogenic differentiation by type beta transforming growth factor.

1986 • 408 citations

Developmentally regulated production of platelet-derived growth factor-like molecules

1984 • 368 citations

Microinjected c- myc as a Competence Factor

1985 • 361 citations

c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF

1985 • 331 citations

Stimulation of aortic smooth muscle cell mitogenesis by serotonin.

1986 • 327 citations

An antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells.

1985 • 315 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Effects of angiotensin II and vasopressin on human smooth muscle cells in vitro

1981 • 306 citations

In Vitro Model for Stretch-Induced Hypertrophy of Skeletal Muscle

1979 • 265 citations

Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression.

1986 • 263 citations

Control of smooth muscle cell growth by components of the extracellular matrix: autocrine role for thrombospondin.

1986 • 259 citations

Inducible interleukin-1 gene expression in human vascular smooth muscle cells.

1986 • 256 citations

Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation

1988 • 256 citations

Effect of chronic hypertension and sympathetic denervation on wall/lumen ratio of cerebral vessels.

1980 • 253 citations

Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein.

1985 • 231 citations

Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats.

1987 • 229 citations

Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction.

1985 • 203 citations

Frontiers in Hypertension Research.

1981 • 172 citations

Growth‐stimulating effect of catecholamines on rat aortic smooth muscle cells in culture

1983 • 170 citations

Vascular smooth muscle cell hypertrophy and hyperploidy in the Goldblatt hypertensive rat.

1983 • 168 citations

Disturbances in neurogenic control of the circulation

1981 • 155 citations

The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

1985 • 143 citations

Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor.

1987 • 139 citations

Vascular cell interactions with special reference to the pathogenesis of atherosclerosis.

1986 • 139 citations

Regulation of oncogene expression in cultured aortic smooth muscle cells. Post-transcriptional control of c-myc mRNA.

1986 • 131 citations

Endothelial Cell Influences on Vascular Smooth Muscle Phenotype

1986 • 109 citations

Phenotype modulation in primary cultures of arterial smooth-muscle cells

1984 • 106 citations

Polyploid nuclei in human artery wall smooth muscle cells.

1983 • 86 citations

Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules.

1987 • 85 citations

Variables controlling the secretion of a somatomedin-like peptide by cultured porcine smooth muscle cells.

1985 • 81 citations

Trophic influences of sympathetic nerves and cyclic AMP on differentiation and proliferation of isolated smooth muscle cells in culture

1975 • 58 citations

Angiotensin II stimulation of vascular smooth muscle phosphoinositide metabolism. State of the art lecture.

1987 • 58 citations

Effect of prostaglandin E1 on DNA synthesis in vascular smooth muscle cells

1986 • 54 citations

The Molecules That Initiate Cardiac Hypertrophy Are Not Species-Specific

1982 • 38 citations

Differential structural responses of small resistance vessels to antihypertensive therapy.

1987 • 36 citations

Catecholamine-induced polyploidization in vascular smooth muscle cells.

1987 • 35 citations

A technique to investigate surface morphology and endothelial cell replication of small arteries: A study in acute angiotensin-induced hypertensive rats

1982 • 34 citations

Comparative effects of hydralazine and captopril on the cardiovascular changes in spontaneously hypertensive rats.

1984 • 31 citations

Increased aortic DNA synthesis precedes renal hypertension in rats. An obligatory step?

1986 • 31 citations

Norepinephrine sensitivity and membrane potentials of caudal arterial muscle in DOCA-salt, Dahl, and SHR hypertension in rat.

1982 • 22 citations

Increased arteriolar wall-to-lumen ratio in a normotensive vascular bed in coarctation hypertension

1985 • 18 citations

Effects of deoxycorticosterone/salt hypertension on cell ploidy in rat aortic smooth muscle cells.

1987 • 17 citations

Antihypertensive drugs inhibit hypertension-associated aortic DNA synthesis in the rat.

1986 • 16 citations

Growth kinetics as a function of ploidy in diploid, tetraploid, and octaploid smooth muscle cells derived from the normal rat aorta

1985 • 14 citations

8 Angiotensin II induction of c-fos, c-myc and platelet-derived growth factor in vascular smooth muscle cells

1988 • 13 citations

Hypertension-Induced Vascular Fibrosis and its Reversal by Antihypertensive Drugs

1981 • 10 citations