Heterogeneity of kupffer cells and splenic, alveolar, and peritoneal macrophages for the production of TNF, IL-1, AND IL-6

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

1990 • 1,377 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Interleukin-1 and Its Biologically Related Cytokines

1989 • 1,180 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages.

1990 • 826 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

1989 • 651 citations

Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response.

1989 • 461 citations

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 • 379 citations

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites.

1991 • 373 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Interleukin 6, the third mediator of acute‐phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 β and tumor necrosis factor‐α

1988 • 287 citations

Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes.

1993 • 238 citations

Human tumor necrosis factor alpha gene regulation by virus and lipopolysaccharide.

1990 • 236 citations

Mechanisms generating functionally heterogeneous macrophages: chaos revisited

1993 • 221 citations

PLASMA CYTOKINES FOLLOWING THERMAL INJURY AND THEIR RELATIONSHIP WITH PATIENT MORTALITY, BURN SIZE, AND TIME POSTBURN

1993 • 198 citations

Specific endotoxic lipopolysaccharide-binding proteins on murine splenocytes. I. Detection of lipopolysaccharide-binding sites on splenocytes and splenocyte subpopulations.

1988 • 173 citations

Regulation of monokine gene expression: prostaglandin E2 suppresses tumor necrosis factor but not interleukin-1 alpha or beta-mRNA and cell-associated bioactivity.

1989 • 149 citations

Regulation of Monokine Gene Expression: Prostaglandin E2 Suppresses Tumor Necrosis Factor but Not Interleukin-1α or β-mRNA and Cell-Associated Bioactivity

1989 • 115 citations

Differential Production of Tumor Necrosis Factor, Macrophage Colony Stimulating Factor, and Interleukin 1 by Human Alveolar Macrophages

1989 • 115 citations

ROLE OF KUPFFER CELLS IN INTERLEUKIN-6 RELEASE FOLLOWING TRAUMA-HEMORRHAGE AND RESUSCITATION

1994 • 111 citations

Regulation of NF‐κB activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester

1992 • 105 citations

Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand.

1987 • 102 citations

Alveolar macrophages differ from blood monocytes in human IL-1 beta release. Quantitation by enzyme-linked immunoassay.

1989 • 101 citations

Signals involved in interleukin 1 synthesis and release by lipopolysaccharide-stimulated monocytes/macrophages

1990 • 101 citations

Differential effects of interferon-alpha and interferon-gamma on interleukin 1 secretion by monocytes.

1987 • 95 citations

Prostaglandin E2-Mediated Inactivation of Various Killer Lineage Cells by Tumor-Bearing Host Macrophages

1988 • 91 citations

Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin

1992 • 83 citations

Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing.

1992 • 81 citations

Elevation of interleukin-6 in response to a chronic inflammatory stimulus in mice: inhibition by indomethacin

1992 • 63 citations

Human monocyte heterogeneity: Interleukin 1 and prostaglandin E₂ production by separate subsets

1985 • 62 citations

Regulation of IL-1 and TNF-alpha expression during the differentiation of bone marrow derived macrophage.

1989 • 55 citations

Transition from interleukin 1 beta (IL-1 beta) to IL-1 alpha production during maturation of inflammatory macrophages in vivo.

1992 • 47 citations

SHORT COMMUNICATION: Bone Marrow Progenitors Cultured in the Presence of Granulocyte-Macrophage Colony-Stimulating Factor Versus Macrophage Colony-Stimulating Factor Differentiate Into Macrophages With Distinct Tumoricidal Capacities

1988 • 45 citations

Protective immunity and granuloma formation are mediated by two distinct tumor necrosis factor alpha- and gamma interferon-dependent T cell-phagocyte interactions in murine listeriosis: dissociation on the basis of phagocyte adhesion mechanisms

1992 • 43 citations

Production of tumor necrosis factor α by resident and activated murine macrophages

1992 • 41 citations

Comparison of the production of eicosanoids by human and rat peritoneal macrophages and rat Kupffer cells

1988 • 38 citations

Isolated pulmonary infection acts as a source of systemic tumor necrosis factor

1994 • 33 citations

Regulation of tumor necrosis factor production by monocyte-macrophages and lymphocytes

1991 • 28 citations

Gene regulation in macrophage development and activation.

1989 • 24 citations

Differential antigen presentation by cloned populations of mouse splenic macrophages.

1989 • 21 citations

Heterogeneity of macrophages in response to lymphokines and other signals

1982 • 21 citations

Biologic and Immunohistochemical Analysis of Macrophage lnterleukin-1α, -1β, and Tumor Necrosis Factor Production During the Peritoneal Exudative Response

1989 • 19 citations

The production of C3, PGE2 and TxB2 by splenic, alveolar, and peritoneal guinea pig macrophages

1988 • 16 citations

Regulation of MHC gene expression during the differentiation of bone marrow-derived macrophages

1989 • 14 citations

A comparison of hepatic, splenic, peritoneal and alveolar macrophages with respect to PGE2, TXB2, production and ADCC function

1993 • 13 citations

Bacterial endotoxin regulation of cytokine receptors on murine bone marrow cells: in vivo and in vitro study.

1994 • 11 citations

Macrophage function in response to PGE2, L-arginine deprivation, and activation by colony-stimulating factors is dependent on hematopoietic stimulus

1992 • 11 citations

Rapid Killing of Actinomycin D-Treated Tumor Cells by Mononuclear Phagocytes: Characterization of Effector Cells in Mice

1986 • 10 citations