The Biology of Peroxisome Proliferator-Activated Receptors

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

The hormone resistin links obesity to diabetes

2001 • 4,720 citations

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 4,335 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*

1999 • 2,880 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.

1996 • 2,130 citations

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

2002 • 2,024 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein

2001 • 1,659 citations

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

1999 • 1,589 citations

Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors

1992 • 1,362 citations

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

1999 • 1,350 citations

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

1999 • 1,339 citations

A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

1998 • 1,339 citations

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

2003 • 1,260 citations

PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.

1996 • 1,169 citations

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 • 1,147 citations

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss*

2000 • 1,011 citations

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

2002 • 969 citations

A critical role for the peroxisome proliferator-activated receptor α (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders

1999 • 931 citations

Altered Constitutive Expression of Fatty Acid-metabolizing Enzymes in Mice Lacking the Peroxisome Proliferator-activated Receptor α (PPARα)

1998 • 851 citations

The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

2002 • 722 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 694 citations

Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion

2001 • 637 citations

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

2000 • 605 citations

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

2002 • 588 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.

1994 • 558 citations

Expression of Putative Fatty Acid Transporter Genes Are Regulated by Peroxisome Proliferator-activated Receptor α and γ Activators in a Tissue- and Inducer-specific Manner

1998 • 526 citations

Peroxisome Proliferator-Activated Receptors: From Genes to Physiology

2001 • 425 citations

Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ Agonists

2001 • 419 citations

Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice

2002 • 405 citations

Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter

1995 • 396 citations

Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation

2000 • 388 citations

Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.

1994 • 380 citations

Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones

2000 • 367 citations

PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes.

1998 • 349 citations

Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

2001 • 348 citations

Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

2000 • 308 citations

Pioglitazone Induces In Vivo Adipocyte Differentiation in the Obese Zucker fa/fa Rat

1997 • 286 citations

A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis

2000 • 265 citations

PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism

2002 • 254 citations

PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

2001 • 235 citations

Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat

1997 • 235 citations

Peroxisome Proliferator-Activated Receptor-α Regulates Fatty Acid Utilization in Primary Human Skeletal Muscle Cells

2002 • 222 citations

WY14,643, a Peroxisome Proliferator-activated Receptor α (PPARα) Agonist, Improves Hepatic and Muscle Steatosis and Reverses Insulin Resistance in Lipoatrophic A-ZIP/F-1 Mice

2002 • 196 citations

Expression of Peroxisome Proliferator-activated Receptor PPARδ Promotes Induction of PPARγ and Adipocyte Differentiation in 3T3C2 Fibroblasts

1999 • 158 citations

Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway

2001 • 150 citations

Differential involvement of peroxisome-proliferator-activated receptors α and δ in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine

2001 • 146 citations

A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice

2002 • 141 citations

Hypoxia Up-regulates Expression of Peroxisome Proliferator-activated Receptor γ Angiopoietin-related Gene (PGAR) in Cardiomyocytes: Role of Hypoxia Inducible Factor 1α

2002 • 137 citations

Ppars, metabolic disease and atherosclerosis

2001 • 115 citations

PPARa activators improve insulin sensitivity and reduce adiposity

2000 • 96 citations

Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway

2001 • 74 citations

Co-ordinate induction of hepatic mitochondrial and peroxisomal carnitine acyltransferase synthesis by diet and drugs

1989 • 60 citations

Monitoring of PPAR Alpha Protein Expression in Human Tissue by the Use of PPAR Alpha-Specific MAbs

1998 • 51 citations

Evidence for Transcriptional Induction of the Liver Fatty‐Acid‐Binding‐Protein Gene by Bezafibrate in the Small Intestine

1995 • 33 citations

Evidence for Transcriptional Induction of the Liver Fatty-Acid-Binding-Protein Gene by Bezafibrate in the Small Intestine

1995 • 25 citations