Identification of the cytochrome P450 enzymes involved in the metabolism of cisapride: in vitro studies of potential co‐medication interactions

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Protein Determination of Large Numbers of Samples

1959 • 1,591 citations

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1991 • 997 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1990 • 423 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Pharmacokinetic Drug Interactions of Macrolides

1992 • 355 citations

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

1996 • 342 citations

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

1993 • 310 citations

Purification and characterization of human liver microsomal cytochrome P-450 2A6.

1991 • 267 citations

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation ofin vitrometabolism using cDNA-expressed human P450s and human liver microsomes

1996 • 263 citations

Inhibition by fluoxetine of cytochrome P450 2D6 activity

1993 • 259 citations

Cisapride

1994 • 242 citations

Cisapride

1988 • 219 citations

Clinical Pharmacokinetics of Ketoconazole

1988 • 218 citations

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1990 • 207 citations

Tolbutamide hydroxylation by human liver microsomes

1988 • 198 citations

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

1990 • 193 citations

Effect of cisapride on gastric and esophageal emptying in insulin-dependent diabetes mellitus

1987 • 179 citations

Inhibition of Alprazolam and Desipramine Hydroxylation In Vitro by Paroxetine and Fluvoxamine

1995 • 174 citations

The influence of cisapride and clarithromycin on QT intervals in healthy volunteers

1998 • 150 citations

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation.

1993 • 143 citations

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

1996 • 143 citations

Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.

1996 • 139 citations

Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.

1997 • 132 citations

Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 db1 activity

1989 • 117 citations

Dual effects of macrolide antibiotics on rat liver cytochrome P-450

1983 • 116 citations

Comparison of Caffeine Metabolism by Slices, Microsomes and Hepatocyte Cultures from Adult Human Liver

1989 • 99 citations

Review article: promotility drugs in the treatment of gastro‐oesophageal reflux disease

1993 • 99 citations

The risk of serious cardiac arrhythmias among cisapride users in the United Kingdom and Canada11This study is based in part on data provided by the Saskatchewan Department of Health. The interpretation and conclusions contained herein do not necessarily represent those of the Government of Saskatchewan or the Saskatchewan Department of Health.

1999 • 91 citations

Cisapride

1996 • 90 citations

Prokinetic benzamides stimulate peristaltic activity in the isolated guinea pig ileum by activation of 5-HT4 receptors

1991 • 74 citations

The action of cisapride on gastric emptying and the pharmacodynamics and pharmacokinetics of oral diazepam

1986 • 71 citations

Comparative effects of two antimycotic agents, ketoconazole and terbinafine on the metabolism of tolbutamide, ethinyloestradiol, cyclosporin and ethoxycoumarin by human liver microsomes in vitro.

1989 • 68 citations

Pharmacokinetic Drug Interactions with Gastrointestinal Motility Modifying Agents

1994 • 62 citations

Drug Interactions with Quinolone Antibacterials

1992 • 61 citations

Excretion and biotransformation of cisapride in dogs and humans after oral administration.

1988 • 57 citations

Influence of grapefruit juice on cisapride pharmacokinetics

1999 • 57 citations

Prolongation of the QT Interval Related to Cisapride‐Diltiazem Interaction

1998 • 54 citations

Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites

1995 • 51 citations

Purification and characterization of an anticonvulsant-induced human cytochrome P-450 catalysing cyclosporin metabolism

1989 • 50 citations

Cisapride-Cimetidine Interaction

1989 • 33 citations

Determination of p-Nitrophenol Hydroxylase Activity of Rat Liver Microsomes by High-Pressure Liquid Chromatography

1993 • 30 citations

Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes

1990 • 23 citations

Metabolism of gestodene in human liver cytosol and microsomes in vitro

1993 • 21 citations

Modulation of cytochrome P450 activities by 7,8-benzoflavone and its metabolites.

1994 • 18 citations

EFFECT OF CISAPRIDE ON MORPHINE ABSORPTION AFTER ORAL ADMINISTRATION OF SUSTAINED-RELEASE MORPHINE

1991 • 14 citations

Report from the NASPGN Therapeutics Subcommittee

1996 • 6 citations

Synthesis of ³H‐ and ¹⁴C‐cisapride

1987 • 5 citations