Essential differences in cholesteryl ester metabolism between human monocyte-derived and J774 macrophages. Evidence against the presence of hormone-sensitive lipase in human macrophages.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts.

1976 • 1,032 citations

Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.

1984 • 994 citations

Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.

1985 • 706 citations

The Pathogenesis of Atherosclerosis: Atherogenesis and Inflammation

1989 • 701 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

The role of the monocyte in atherogenesis: II. Migration of foam cells from atherosclerotic lesions.

1981 • 468 citations

Molecular cloning : a laboratory manual. Cold Spring Harbor, NY

1989 • 364 citations

Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit.

1986 • 296 citations

Initiation of atherosclerotic lesions in cholesterol-fed rabbits. I. Focal increases in arterial LDL concentration precede development of fatty streak lesions.

1989 • 272 citations

Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit.

1986 • 267 citations

The Hydrolysis of Long-chain Fatty Acid Esters of Cholesterol with Rat Liver Enzymes

1962 • 182 citations

Low density lipoprotein metabolism by human macrophages activated with low density lipoprotein immune complexes. A possible mechanism of foam cell formation.

1988 • 174 citations

Phosphorylation of hormone-sensitive lipase by cyclic AMP-dependent protein kinase.

1983 • 173 citations

Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells.

1982 • 170 citations

Atherogenesis during low level hypercholesterolemia in the nonhuman primate. I. Fatty streak formation.

1990 • 169 citations

Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation

1993 • 168 citations

Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium.

1993 • 151 citations

Foam cells in explants of atherosclerotic rabbit aortas have receptors for beta-very low density lipoproteins and modified low density lipoproteins.

1983 • 147 citations

Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.

1990 • 143 citations

Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level.

1991 • 137 citations

Identification of foam cells in human atherosclerotic lesions as macrophages using monoclonal antibodies.

1985 • 122 citations

Human serum induces maturation of human monocytes in vitro. Changes in cytolytic activity, intracellular lysosomal enzymes, and nonspecific esterase activity.

1983 • 119 citations

Neutral cholesterol esterase activity in macrophages and its enhancement by cAMP-dependent protein kinase.

1981 • 114 citations

Differential requirements for cellular cytoskeleton in human macrophage complement receptor- and Fc receptor-mediated phagocytosis.

1991 • 113 citations

Arterial neutral cholesteryl esterase. A hormone-sensitive enzyme distinct from lysosomal cholesteryl esterase.

1983 • 96 citations

cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.

1991 • 90 citations

Hormone‐sensitive lipase is responsible for the neutral cholesterol ester hydrolase activity in macrophages

1989 • 88 citations

Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells.

1990 • 76 citations

Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits

1992 • 63 citations

Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits.

1990 • 61 citations

Cell proliferation in normal and atherosclerotic human aorta. II. Autoradiographic observation on deoxyribonucleic acid synthesis in primary cell culture.

1983 • 59 citations

Evidence for phosphorylation/dephosphorylation of rat liver acyl-CoA:cholesterol acyltransferase.

1983 • 58 citations

Dual modulation of hepatic and intestinal acyl‐CoA: cholesterol acyltransferase activity by (de‐)phosphorylation and substrate supply in vitro

1983 • 54 citations

Low density lipoprotein metabolism in human macrophages stimulated with microbial or microbial-related products.

1987 • 51 citations

Cellular events in the development of valvular atherosclerotic lesions induced by experimental hypercholesterolemia

1987 • 51 citations

Macrophage uptake of cholesterol-containing particles derived from LDL and isolated from atherosclerotic lesions

1990 • 51 citations

Activation of rat liver cholesterol ester hydrolase by cAMP‐dependent protein kinase and protein kinase C

1989 • 49 citations

Subcellular distribution and kinetics of the acid cholesterol esterase in liver

1972 • 47 citations

Stimulation of a neutral cholesteryl ester hydrolase by cAMP system in P388D1 macrophages

1990 • 45 citations

Phosphorylation and activation of hormone‐sensitive lipase in isolated macrophages

1991 • 42 citations

Nucleotide sequence of rat adipose hormone sensitive lipase cDNA

1988 • 41 citations

Regulation of neutral cholesteryl esterase in arterial smooth muscle cells: Stimulation by agonists of adenylate cyclase and cyclic AMP-dependent protein kinase

1986 • 41 citations

A defect in mobilization of cholesteryl esters in rabbit macrophages

1985 • 36 citations

Endocytosis of oxidized LDL and reversibility of migration inhibition in macrophage-derived foam cells in vitro. A mechanism for atherosclerosis regression?

1992 • 29 citations

A modified ‘low pH’ lignocaine method to isolate human monocytes: A comparison with other separation procedures

1981 • 28 citations

Effect of cAMP-elevating drugs on Ca2+ efflux and actin polymerization in peritoneal macrophages stimulated with N-formyl chemotactic peptide

1984 • 24 citations

Glueagon-and Dibutyrul Cyclic AMP-Produced Inhibition of Cholesterol Ester Hydrolase in Isolated Rat Hepatocytes: Role of Calcium1

1990 • 19 citations

Neutral cholesteryl ester hydrolase in the rat lactating mammary gland: regulation by phosphorylation-dephosphorylation

1990 • 18 citations

Evidence against a role for phosphorylation/dephosphorylation in the regulation of acyl‐CoA: cholesterol acyl transferase

1992 • 17 citations

Regulation of RAW264 macrophage morphology and spreading: studies with protein kinase C activators, inhibitors and a cyclic AMP analog

1989 • 16 citations

Biphasic regulation of macrophage attachment by activators of cyclic adenosine monophosphate‐dependent kinase and protein kinase C

1989 • 15 citations

Cholesterol crystal uptake and metabolism by P388D1 macrophages

1989 • 15 citations

Cyclic AMP and the regulation of cholesterol metabolism

1992 • 13 citations

Possible role of macrophages in regression of atherosclerosis

1991 • 13 citations

Cholesterol Ester Hydrolysis in Isolated Rat Liver Cells. Effect of Estradiol, Dibutyryl Cyclic AMP and Free Fatty Acids

1988 • 8 citations

Cholesteryl ester hydrolase: three activities in the lactating rat mammary gland

1990 • 4 citations