Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism.

An improved Bonferroni procedure for multiple tests of significance

1986 • 2,201 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

Polymorphic dextromethorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquin hydroxylation

1985 • 386 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Polymorphism of propafenone metabolism and disposition in man: clinical and pharmacokinetic consequences.

1987 • 281 citations

Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism

1984 • 271 citations

High-performance liquid chromatographic assays for bufuralol 1′-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver

1987 • 262 citations

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.

1982 • 213 citations

Propranolol's metabolism is determined by both mephenytoin and debrisoquin hydroxylase activities

1989 • 178 citations

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

1985 • 173 citations

Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors.

1987 • 152 citations

Polymorphic debrisoquin hydroxylation in 757 Swedish subjects

1988 • 135 citations

The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation

1986 • 130 citations

MPTP, the neurotoxin inducing parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation

1987 • 130 citations

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1989 • 116 citations

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.

1987 • 112 citations

Phenotypic differences in mephenytoin pharmacokinetics in normal subjects.

1985 • 96 citations

Phenotyping polymorphic drug metabolism in the French Caucasian population

1988 • 75 citations

Anti-liver kidney microsome antibody type 1 recognizes human cytochrome P450 db1

1989 • 71 citations

Sparteine Oxidation Polymorphism in Denmark

1985 • 68 citations

Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation

1986 • 68 citations

Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design.

1989 • 67 citations

Polymorphic metabolism of mephenytoin in man: Pharmacokinetic interaction with a co-regulated substrate, mephobarbital

1986 • 51 citations

Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis

1989 • 50 citations

α-Helical coiled-coil structures of Trypanosoma brucei variable surface glycoproteins

1984 • 49 citations

Polymorphism of dextromethorphan oxidation in a French population.

1987 • 48 citations

Dextromethorphan: polymorphic serum pattern of the O‐demethylated and didemethylated metabolites in man.

1989 • 46 citations

GC and GC-MS procedures for simultaneous phenotyping with dextromethorphan and mephenytoin

1988 • 44 citations

Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians

1984 • 41 citations

Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark.

1989 • 33 citations

Mephenytoin hydroxylation in the Cuna Amerindians of Panama.

1988 • 30 citations

The genetic defect of mephenytoin hydroxylation

1986 • 27 citations

Simplified Phenotyping with Dextromethorphan by Thin-Layer Chromatography

1988 • 26 citations

Polymorphisms in oxidative drug metabolism: relationship to food preference.

1991 • 12 citations

Thin-Layer Chromatographic Screening Test for Polymorphic Sparteine Oxidation

1989 • 8 citations

Variability in drug metabolism: importance of genetic constitution

1987 • 7 citations