The hormonal and metabolic basis of experimental obesity

Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles

1964 • 729 citations

Effects of parabiosis of obese with diabetes and normal mice

1973 • 728 citations

Glucostatic Mechanism of Regulation of Food Intake

1953 • 635 citations

Neural control of the endocrine pancreas.

1974 • 630 citations

Glucose and Osmosensitive Neurones of the Rat Hypothalamus

1969 • 588 citations

The efferent connections of the ventromedial nucleus of the hypothalamus of the rat,

1976 • 512 citations

Insulin-Receptor Interactions in Adipose Tissue Cells: Direct Measurement and Properties

1971 • 443 citations

Insulin and Obesity in the Zucker Genetically Obese Rat “Fatty”

1972 • 420 citations

Insulin-Receptor Interaction in the Obese-Hyperglycemic Mouse

1973 • 408 citations

Genetically transmitted obesity in rodents

1971 • 405 citations

Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism

1968 • 393 citations

The influence of genetic background on the expression of the obese (ob) gene in the mouse

1973 • 387 citations

Activity of single neurons in the hypothalamic feeding centers: effect of glucose

1964 • 386 citations

Hunger, obesity, and the ventromedial hypothalamus.

1972 • 344 citations

Effects of parabiosis of normal with genetically diabetic mice

1969 • 326 citations

Overeating and Obesity from Damage to a Noradrenergic System in the Brain

1973 • 303 citations

Effect of hypothalamic stimulation on plasma glucose, insulin, and glucagon levels

1971 • 291 citations

Hypothalamic Obesity: The Myth of the Ventromedial Nucleus

1973 • 291 citations

Cellularity of adipose depots in six strains of genetically obese mice

1972 • 273 citations

Insulin Receptor Deficiency in Genetic and Acquired Obesity

1975 • 262 citations

The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains

1972 • 260 citations

Nervous Regulation of Food Intake

1961 • 237 citations

Reciprocal Influences of the Ventromedial and Lateral Hypothalamic Nuclei on Blood Glucose Level and Liver Glycogen Content

1966 • 236 citations

Postnatal development of adipocyte cellularity in the normal rat

1974 • 231 citations

Cellularity of adipose depots in the genetically obese Zucker rat

1971 • 219 citations

Reciprocal Hunger-Regulating Circuits Involving Alpha-and Beta-Adrenergic Receptors Located, Respectively, in the Ventromedial and Lateral Hypothalamus

1970 • 187 citations

The effect of insulin upon glucose metabolism by adipose cells of different size

1971 • 185 citations

Determinants of Food Intake in Obesity

1968 • 182 citations

Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice.

1976 • 167 citations

Fat accretion and growth in the rat.

1963 • 159 citations

Plasma insulin and triglyceride levels after hypothalamic lesions in weanling rats

1969 • 157 citations

Impairment of insulin binding to the fat cell plasma membrane in the obese hyperglycemic mouse

1972 • 155 citations

Effects of hypothalamic stimulation on gluconeogenesis and glycolysis in rat liver

1975 • 153 citations

Neural Regulation of Insulin Secretion in the Dog

1973 • 150 citations

Hyperinsulinemia in pre-weaning diabetes (db) mice

1974 • 148 citations

Development of the obese-hyperglycaemic syndrome in mice

1968 • 147 citations

Role of Free Fatty Acids in Glucose Homeostasis

1969 • 145 citations

Insulin Receptors in Human Circulating Lymphocytes: Application to the Study of Insulin Resistance in Man*

1973 • 139 citations

Dependence of Hypothalamic Obesity on Insulin, the Pituitary and the Adrenal Gland11

1972 • 139 citations

Metabolism in Vitro of Adipose Tissue in Obese-hyperglycemic and Goldthioglucose-treated Mice

1961 • 134 citations

Correlation between Hyperinsulinemia and Hyperphagia in Rats with Ventromedial Hypothalamic Lesions

1972 • 134 citations

Hypothalamic Hyperphagia: Dissociation from Hyperphagia Following Destruction of Noradrenergic Neurons

1975 • 131 citations

Inhibitory controls of feeding by the ventromedial hypothalamus

1974 • 130 citations

Metabolism in Vitro of Adipose Tissue in Obese-hyperglycemic and Goldthioglucose-treated Mice

1961 • 129 citations

Interactions of polypeptide hormones with cell membrane specific receptors: Studies with insulin and glucagon

1976 • 122 citations

Effect of Early Nutrition on Adipose Cellularity and Pancreatic Insulin Release in the Zucker Rat

1973 • 120 citations

Insulin Resistance in Genetically Obese, Hyperglycemic Mice

1971 • 115 citations

The regulation of the adipose tissue mass.

1974 • 114 citations

Feeding patterns of normal and ventromedial hypothalamic lesioned male and female rats.

1970 • 111 citations

Studies on food intake of genetically obese rats

1972 • 109 citations

Studies of hereditary-obese mice (obob) after implantation of pancreatic islets in Millipore filter capsules

1970 • 105 citations

Insulin receptor defect in insulin resistance: Studies in the obese-hyperglycemic mouse

1972 • 105 citations

Thymic Lymphocytes in Obese (ob/ob) Mice

1974 • 104 citations

Genetic obesity in rats. I. The effects of food restriction on body composition and hypothalamic function

1973 • 102 citations

Hypothalamic sensitivity to 2-deoxy-D-glucose and glucose: Effects on feeding behavior

1971 • 101 citations

Effect of insulin in vivo on diaphragm and adipose tissue of obese mice

1969 • 100 citations

Insulin Receptors in the Heart Muscle: Demonstration of Specific Binding Sites and Impairment of Insulin Binding in the Plasma Membrane of the Obese Hyperglycemic Mouse

1975 • 97 citations

Insulin Resistance and Pancreatic Insulin Release in the Genetically Obese Zucker Rat

1972 • 94 citations

Overproduction of very low-density lipoproteins by livers of genetically obese rats

1971 • 90 citations

Hyperinsulinemia and insulin resistance in genetically obese rats

1972 • 90 citations

Glucose Metabolism and the Response to Insulin by Human Adipose Tissue in Spontaneous and Experimental Obesity

1974 • 87 citations

Evidence for an insulin-sensitive receptor in the central nervous system

1972 • 85 citations

Rapid effects of insulin on the hypothalamic satiety center

1969 • 83 citations

INFLUENCE OF THE MUTATION "DIABETES" ON INSULIN RELEASE AND ISLET MORPHOLOGY IN MICE OF DIFFERENT GENETIC BACKGROUNDS

1974 • 83 citations

Plasma triglycerides in genetically obese rats

1969 • 82 citations

Fat mobilization in vitro and in vivo in the genetically obese Zucker rat “fatty”

1972 • 80 citations

Food motivated behavior in genetically obese and hypothalamic-hyperphagic rats and mice

1974 • 79 citations

Pancreatic insulin release and peripheral tissue resistance in Zucker obese rats fed high- and low-carbohydrate diets

1975 • 79 citations

The Septo-Preoptico-Hypothalamic System and its Autonomic Function

1966 • 77 citations

lipogenesis and enzyme levels in adipose and liver tissues from pair-fed genetically obese and lean rats

1974 • 71 citations

Hypothalamic glucoreceptors—The influence of gold thioglucose implants in the ventromedial and lateral hypothalamic areas of normal and diabetic rats

1972 • 68 citations

Structural changes of pancreatic islets in genetically obese rats

1973 • 68 citations

Reproductive Function in the Genetically Obese “Fatty” Rat

1973 • 65 citations

Studies on the Metabolic Effects Induced in the Rat by a High‐Fat Diet

1972 • 64 citations

Hypothalamic radioactivity after intragastric glucose- 14 C in rats

1972 • 62 citations

Obesity and increased growth following partial or complete isolation of ventromedial hypothalamus

1971 • 57 citations

Plasma lipoproteins and the synthesis and turnover of plasma triglyceride in normal and genetically obese mice

1973 • 57 citations

STIMULATION OF INSULIN RELEASE BY A VENTROLATERAL HYPOTHALAMIC FACTOR

1971 • 57 citations

Ventromedial syndrome: The rat's "finickiness" results from the obesity, not from the lesions.

1974 • 57 citations

Ventromedial hypothalamic control of food intake and satiety: A reappraisal

1972 • 56 citations

THE HYPOTHALAMUS, ESPECIALLY ON ITS FIBER CONNECTIONS, AND THE SEPTO-PREOPTICO-HYPOTHALAMIC SYSTEM.

1964 • 56 citations

Abnormalities in lipogenesis and triglyceride secretion by perfused livers of obese-hyperglycaemic (ob/ob) mice: Relationship with hyperinsulinaemia

1974 • 53 citations

Spontaneous Hyperglycemia and/or Obesity in Laboratory Rodents: An Example of the Possible Usefulness of Animal Disease Models with Both Genetic and Environmental Components

1971 • 53 citations

An anomaly of insulin removal in perfused livers of obese-hyperglycemic (ob/ob) mice.

1976 • 52 citations

Amelioration of insulin resistance in obese mice

1971 • 52 citations

Insulin and Growth Hormone Secretion in Rats with Ventromedial Hypothalamic Lesions Maintained on Restricted Food Intake

1974 • 51 citations

The effects of hypothalamics lesions in genetically diabetic mice

1970 • 51 citations

Thyrotropin Secretion in Genetically Obese Rats

1972 • 50 citations

Food intake in hypothalamic obesity

1974 • 49 citations

Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice ()

1974 • 47 citations

In vivo studies on lipogenesis in obese hyperglycaemic (ob/ob) mice: Possible role of hyperinsulinaemia

1974 • 46 citations

Hyperinsulinism in Mice with Genetically Determined Obesity

1969 • 46 citations

Hormonal Control of Intermediary Metabolism in Obese Hyperglycemic Mice: I. The Sensitivity and Response to Insulin in Adipose Tissue and Muscle in Vitro

1971 • 45 citations

Genetic versus hypothalamic obesity: Studies of intake and dietary manipulations in rats.

1974 • 45 citations

Glucose tolerance and time sequence of adiposity, hyperinsulinemia and hyperglycemia in obese-hyperglycemic mice (obob)

1970 • 45 citations

Obesity and insulin resistance in the obese-hyperglycemic mouse (obob)

1969 • 44 citations

Regulation of glycerol kinase by insulin in isolated fat cells and liver of Bar Harbor Obese Mice

1971 • 44 citations

Ce:Role of the increased adipose tissue mass in the apparent insulin insensitivity of obesity

1972 • 43 citations

Induction of diabetic alterations by goldthioglucose-obesity in KK, ICR and C57BL mice

1972 • 43 citations

The autoregulation of insulin secretion in the isolated pancreatic islets of lean (obOb) and obese-hyperglycemic (obob) mice

1974 • 42 citations

Lipoprotein lipase activities in adipose tissues, heart and diaphragm of the genetically obese mouse(ob-ob)

1972 • 41 citations

Central and Sensory Control of Food Intake in Genetically Obese Mice

1955 • 37 citations

Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic micce

1970 • 37 citations

Enlarged pancreatic islets of tube-fed hypophysectomized rats bearing hypothalamic lesions

1970 • 35 citations

Genetic obesity in rats. II. The effect of food restriction on the metabolism of adipose tissue

1973 • 35 citations

An Impaired Response of Adenylate Cyclase to Stimulation by Epinephrine in Adipocyte Plasma Membranes from Genetically Obese Mice (ob/ob)

1975 • 34 citations

Clearing-factor lipase in obese–hyperglycaemic mice (ob/ob)

1972 • 34 citations

Neuroendocrine conditioning: conditioned feeding after alterations in glucose utilization

1975 • 33 citations

Hormonal Control of Intermediary Metabolism in Obese Hyperglycemic Mice: II. Levels of Plasma Free Fatty Acid and Immunoreactive Insulin and Liver Glycogen

1971 • 33 citations

The control of insulin receptors in the New Zealand obese mouse

1975 • 32 citations

Insulin receptors in the heart muscle. Demonstration of specific binding sites and impairment of insulin binding in the plasma membrane of the obese hyperglycemic mouse

1975 • 32 citations

Further studies on the amelioration of the characteristics of New Zealand Obese (NZO) mice following implantation of islets of Langerhans

1974 • 31 citations

Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice

1975 • 30 citations

Genetic control of metabolism: enzyme studies of theobeseandadiposemutants in the mouse

1972 • 30 citations

HYPOTHALAMIC STIMULATION OF INSULIN RELEASE

1973 • 29 citations

Relation of insulin receptors to insulin resistance.

1975 • 29 citations

Effects of glucose on multi-unit activity in the hypothalamus

1969 • 28 citations

Adaptive enzyme responses in adipose tissue of obese hyperglycemic mice

1973 • 27 citations

An analysis of the lipolysis in vitro of obese-hyperglycaemic and diabetic mice

1969 • 27 citations

Ventromedial hypothalamic hyperphagia in the hypophysectomized weanling rat.

1972 • 26 citations

Adipose-tissue lipoprotein lipase activity and cellularity in the genetically obese Zucker rat (fa/fa) (Short Communication)

1973 • 26 citations

Ventromedial hypothalamus and hyperphagia in hyperglycemic obese mice

1970 • 26 citations

Metabolic and endocrine aspects of the ventromedial hypothalamic syndrome in the rat.

1974 • 26 citations

Studies of insulin sensitivity in vivo in weanling rats with hypothalamic obesity

1972 • 25 citations

Sequential changes in glucose metabolism by adipose tissue and liver of rats after destruction of the ventromedial hypothalamic muclei: Effect of three dietary regimens

1972 • 25 citations

Metabolism of intravenously injected 14C-glucose in weanling rats with hypothalamic obesity

1972 • 24 citations

Function of the pancreatic B-cell during the development of hyperglycaemia in mice homozygous for the mutations ?diabetes? (db) and ?Misty? (m)

1975 • 24 citations

Multiple knife cuts between the medial and lateral hypothalamus in the rat: A reevaluation of hypothalamic feeding circuitry.

1975 • 23 citations

A COMBINED BIOCHEMICAL AND HISTOLOGICAL STUDY ON THE ISLETS OF LANGERHANS IN THE GENETICALLY OBESE HYPERGLYCAEMIC MOUSE AND IN THE LEAN MOUSE, INCLUDING OBSERVATIONS ON THE EFFECTS OF STREPTOZOTOCIN TREATMENT

1973 • 22 citations

Early Development of Adipose Cell Lipogenesis and Glycerol Utilization in Zucker Obese Rats

1975 • 22 citations

Lipoprotein Lipase Activities in Tissues of Normal and Genetically Obese (ob/ob) Mice

1974 • 22 citations

In vivo and in vitro metabolism in hypothalamic obesity

1972 • 21 citations

Insulin Resistance of Parabiotic Obese-Hyperglycemic Mice (obob)

1972 • 21 citations

Hepatic metabolism in normal and genetically obese mice

1974 • 20 citations

Kinetics of Immunoreactive Insulin Release in Obese Hyperglycemic Laboratory Rodents*

1973 • 20 citations

Does hyperinsulinemia in ob/ob mice cause an insulin-stimulated adipose tissue?

1976 • 20 citations

Lipogenesis in adipose tissue from genetically obese rats

1970 • 18 citations

Fatty Acid Mobilization in Obese Mice

1970 • 18 citations

Kinetic and electrophoretic abnormality of cyclic AMP phosphodiesterase in genetically obese mouse adipocytes

1973 • 18 citations

ETHOLOGICAL AND NEUROLOGICAL ASPECTS OF THE REGULATION OF FOOD INTAKE

1969 • 18 citations

The metabolism of ketones, triglyceride and monoglyceride in livers of obese hyperglycaemic mice

1970 • 18 citations

In vitro studies on insulin secretion in the genetically obese mouse

1973 • 16 citations

Insulin and Metabolism.

1974 • 15 citations

Correlation between altered acetate utilization and hyperphagia in rats with ventromedial hypothalamic lesions

1973 • 15 citations

Adipose and Liver Tissue Enzyme Profiles in Obese Hyperglycemic Mice

1973 • 15 citations

Symposium III: Hormones and hormone receptors. A morphological approach to surface receptors in islet and liver cells.

1975 • 15 citations

The response of the reproductive system in the female mutant mouse, obese (genotype obob) to gonadotrophin-releasing hormones

1972 • 14 citations

Diabetes-Induced Resistance of Ventromedial Hypothalamus to Damage by Gold Thioglucose: Reversal by Adrenalectomy

1974 • 14 citations

Increased hepatic triacylglycerol secretion in fasted rats with ventromedial hypothalamic lesions

1975 • 14 citations

Enhancement of feeding produced by stimulation of the ventromedial hypothalamus.

1974 • 13 citations

Insulin Responsiveness in Vitro of Diaphragm and Adipose Tissue from Weanling Rats with Hypothalamic Obesity

2009 • 13 citations

Hypertriglyceridemia in Weanling Rats with Hypothalamic Obesity

1971 • 13 citations

Pathogenetic aspects of the obese-hyperglycemic syndrome in mice (genotypeobob): I. Function of the pancreatic B-cells

1970 • 11 citations

Changes in liver and adipose tissue enzymes and lipogenic activities during the onset of hypothalamic obesity in mice

1974 • 11 citations

Insulin sensitivity of pair-fed, hyperlipemic, hyperinsulinemic, obese-hypothalamic rats

1972 • 11 citations

Adaptive response of hepatic acetyl-CoA carboxylase to dietary alterations in genetically obese mice and their lean controls

1974 • 10 citations

Metabolism of Glucose, Fructose and Pyruvate in Tissues of Weanling Rats with Hypothalamic Obesity

1974 • 9 citations

Metabolic anomalies of the obese-hyperglycemic (ob/ob) mice of Bar Harbor.

1975 • 8 citations

Metabolisme Du Glucose Dans Le Tissu Adipeux Et Le Muscle Des Animaux Presentant Une Obesite Metabolique Ou Une Obesite Par Hyperphagie^*

1968 • 8 citations

Reversal by 2-Bromostearate of the Impairment of Glucose and Pyruvate Oxidation in Diaphragm of Fat-Fed Rats, in Vitro

1970 • 8 citations

Lipolysis in the adipose tissue of mice made obese with goldthioglucose

1972 • 6 citations

Enzyme Activities in Muscle and Liver After Destruction of the Ventromedial Hypothalamic Area and Administration of Insulin

1974 • 5 citations

Persistent Adipose Tissue Insulin Responsiveness During Fasting of Weanling Rats with Hypothalamic Obesity

1974 • 5 citations

Nutrition and Diabetes Mellitus.

1973 • 4 citations

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