Geldanamycin augments nitric oxide production and promotes capacitation in boar spermatozoa
Data up to Jan 2025
Total Citations Per Year
Abstract
References (71)
The Physiology of Reproduction
1988 • 7,765 citations
SAS user's guide
1979 • 7,396 citations
Fertilizing Capacity of Spermatozoa deposited into the Fallopian Tubes
1951 • 1,451 citations
Physiology of Reproduction
2000 • 1,184 citations
Dynamic activation of endothelial nitric oxide synthase by Hsp90
1998 • 1,016 citations
Observations on the Penetration of the Sperm into the Mammalian Egg
1951 • 907 citations
Reactive oxygen species and sperm physiology
1997 • 651 citations
Two simple methods for detecting acrosome‐reacted human sperm
1986 • 612 citations
Reactive oxygen species and human spermatozoa. I. Effects on the motility of intact spermatozoa and on sperm axonemes.
1992 • 573 citations
Hsp90: Chaperoning signal transduction
2001 • 569 citations
Reactive Oxygen Species and Human Spermatozoa
1992 • 395 citations
Heat Shock Protein 90 Mediates the Balance of Nitric Oxide and Superoxide Anion from Endothelial Nitric-oxide Synthase
2001 • 323 citations
Regulation of Protein Tyrosine Phosphorylation in Human Sperm by a Calcium/Calmodulin-Dependent Mechanism: Identification of A Kinase Anchor Proteins as Major Substrates for Tyrosine Phosphorylation
1996 • 319 citations
Cholesterol Efflux-mediated Signal Transduction in Mammalian Sperm
1999 • 318 citations
Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.
1996 • 259 citations
Capacitation-associated production of superoxide anion by human spermatozoa
1995 • 259 citations
Role of tyrosine phosphorylation in sperm capacitation / acrosome reaction.
2004 • 258 citations
Capacitation mechanisms, and the role of capacitation as seen in eutherian mammals
1996 • 244 citations
Characterization of the Intracellular Calcium Store at the Base of the Sperm Flagellum That Regulates Hyperactivated Motility1
2003 • 238 citations
Protein phosphorylation in mammalian spermatozoa
2003 • 228 citations
Ca2+Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome Reaction
2000 • 225 citations
Andrology: Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity
1995 • 220 citations
Capacitation Is Associated with Tyrosine Phosphorylation and Tyrosine Kinase-Like Activity of Pig Sperm Proteins1
2001 • 207 citations
Regulators of sperm function
1996 • 202 citations
Low Levels of Nitric Oxide Promote Human Sperm CapacitationIn Vitro
1995 • 182 citations
CABYR, a Novel Calcium-Binding Tyrosine Phosphorylation-Regulated Fibrous Sheath Protein Involved in Capacitation
2002 • 182 citations
p95, the major phosphotyrosine-containing protein in mouse spermatozoa, is a hexokinase with unique properties.
1994 • 178 citations
Estrogen Stimulates Heat Shock Protein 90 Binding to Endothelial Nitric Oxide Synthase in Human Vascular Endothelial Cells
2000 • 177 citations
Flow cytometric studies of bicarbonate‐mediated Ca2+ influx in boar sperm populations
1993 • 171 citations
FSP95, A Testis-Specific 95-Kilodalton Fibrous Sheath Antigen That Undergoes Tyrosine Phosphorylation in Capacitated Human Spermatozoa1
1999 • 166 citations
Role of Tyrosine Phosphorylation of Flagellar Proteins in Hamster Sperm Hyperactivation1
1999 • 166 citations
Effect of sodium nitroprusside on sperm motility, viability, and lipid peroxidation
1994 • 165 citations
Neuronal Nitric-oxide Synthase Is Regulated by the hsp90-based Chaperone System in Vivo
1999 • 161 citations
Nitric oxide inhibition of human sperm motility
1995 • 155 citations
The Intraacrosomal Calcium Pool Plays a Direct Role in Acrosomal Exocytosis
2002 • 126 citations
Nitric Oxide Regulates Human Sperm Capacitation and Protein-Tyrosine Phosphorylation In Vitro1
1999 • 119 citations
Nitric Oxide: A Novel Mediator of Sperm Function
2001 • 116 citations
Nitric oxide interacts with the cAMP pathway to modulate capacitation of human spermatozoa
2000 • 115 citations
The acrosomal vesicle of mouse sperm is a calcium store
2004 • 111 citations
Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells
1996 • 111 citations
Protein kinases in mammalian sperm capacitation and the acrosome reaction
1999 • 111 citations
Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones
2001 • 104 citations
Intracellular Ca2+-Mg2+-ATPase Regulates Calcium Influx and Acrosomal Exocytosis in Bull and Ram Spermatozoa1
1999 • 102 citations
Intracellular calcium store depletion and acrosome reaction in human spermatozoa: role of calcium and plasma membrane potential
2001 • 101 citations
Tyrosine Phosphorylation of HSP-90 During Mammalian Sperm Capacitation1
2003 • 98 citations
Initiation of the human sperm acrosome reaction by thapsigargin
1993 • 88 citations
Regionalized Lipid Diffusion in the Plasma Membrane of Mammalian Spermatozoa
1998 • 81 citations
Substantial decrease of heat-shock protein 90 precedes the decline of sperm motility during cooling of boar spermatozoa
1999 • 77 citations
Co-localization of the inositol 1,4,5-trisphosphate receptor and calreticulin in the equatorial segment and in membrane bounded vesicles in the cytoplasmic droplet of human spermatozoa
2001 • 76 citations
Zona Pellucida and Progesterone‐Induced Ca2+ Signaling and Acrosome Reaction in Human Spermatozoa
2002 • 72 citations
Follicular fluid proteins stimulate nitric oxide (NO) synthesis in human sperm: A possible role for NO in acrosomal reaction
1999 • 72 citations
Atrial natriuretic peptide induces acrosomal exocytosis in bovine spermatozoa
1995 • 70 citations
Detection of human sperm acrosome reaction: comparison between methods using double staining, Pisum sativum agglutinin, concanavalin A and transmission electron microscopy
1997 • 59 citations
Evidence for Nitric Oxide Regulation of Hamster Sperm Hyperactivation
1998 • 59 citations
-Arginine promotes capacitation and acrosome reaction in cryopreserved bovine spermatozoa
2004 • 57 citations
Effect of nitric oxide on mouse sperm hyperactivation.
1994 • 57 citations
Nitric oxide-induced capacitation of cryopreserved bull spermatozoa and assessment of participating regulatory pathways
2004 • 52 citations
Identification of the major tyrosine phosphorylated protein of capacitated hamster spermatozoa as a homologue of mammalian sperm a kinase anchoring protein
2002 • 51 citations
The Importance of Calcium in the Appearance of p32, a Boar Sperm Tyrosine Phosphoprotein, During In Vitro Capacitation
2003 • 49 citations
Properties and localization of a tyrosine phosphorylated form of hexokinase in mouse sperm
1996 • 48 citations
The decline of porcine sperm motility by geldanamycin, a specific inhibitor of heat-shock protein 90 (hsp90)
2000 • 48 citations
Identification of capacitation-associated phosphoproteins in porcine sperm electroporated with ATP-?-32P
1999 • 45 citations
The nitric oxide synthase of mouse spermatozoa
1997 • 41 citations
Sperm motility enhancement by nitric oxide produced by the oocytes of fathead minnows, Pimephelas promelas.
1999 • 32 citations
Role of protein tyrosine phosphorylation in the thapsigargin-induced intracellular Ca2+ store depletion during human sperm acrosome reaction
2003 • 28 citations
Sperm Motility Enhancement by Nitric Oxide Produced by the Oocytes of Fathead Minnows, Pimephelas promelas
1998 • 27 citations
Responses of monkey epididymal sperm of different maturational status to second messengers mediating protein tyrosine phosphorylation, acrosome reaction, and motility
1999 • 24 citations
Inhibition of motility of hamster spermatozoa by protein tyrosine kinase inhibitors
2000 • 21 citations
Stimulation of Receptor-Mediated Nitric Oxide Production by Vanadate
2000 • 21 citations
Nitric oxide induces acrosome reaction in cryopreserved bovine spermatozoa
2005 • 20 citations
Inhibition of in vitro capacitation of hamster spermatozoa by nitric oxide synthase inhibitors.
2003 • 19 citations