Recurrent Chromosomal Imbalances Detected in Biopsy Material from Oral Premalignant and Malignant Lesions by Combined Tissue Microdissection, Universal DNA Amplification, and Comparative Genomic Hybridization

Molecular Cloning: A Laboratory Manual

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Molecular cloning: A laboratory manual

1990 • 85,659 citations

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Comparative Genomic Hybridization for Molecular Cytogenetic Analysis of Solid Tumors

1992 • 3,344 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

Degenerate oligonucleotide-primed PCR: General amplification of target DNA by a single degenerate primer

1992 • 1,413 citations

Genetic progression model for head and neck cancer: implications for field cancerization.

1996 • 1,340 citations

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors

1994 • 1,047 citations

Estimates of the worldwide mortality from eighteen major cancers in 1985. Implications for prevention and projections of future burden

1993 • 595 citations

Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization

1993 • 561 citations

Histological Typing of Cancer and Precancer of the Oral Mucosa

1997 • 551 citations

Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment

1996 • 521 citations

Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic model of meningioma progression

1997 • 410 citations

Allelotype of head and neck squamous cell carcinoma.

1994 • 349 citations

Two human c-onc genes are located on the long arm of chromosome 8.

1982 • 329 citations

Genome screening by comparative genomic hybridization

1997 • 313 citations

Quantitative analysis of comparative genomic hybridization

1995 • 304 citations

Multiple head and neck tumors: evidence for a common clonal origin.

1996 • 284 citations

Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas.

1995 • 176 citations

Frequent inactivation of p16INK4a in oral premalignant lesions

1997 • 172 citations

Distinct patterns of chromosomal alterations in high- and low-grade head and neck squamous cell carcinomas.

1996 • 170 citations

Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma.

1995 • 160 citations

Chromosome abnormalities in eighty-three head and neck squamous cell carcinomas: influence of culture conditions on karyotypic pattern.

1993 • 129 citations

Analysis of gene amplification in head‐and‐neck squamous‐cell carcinomas

1991 • 126 citations

Allelotype of squamous cell carcinoma of the head and neck: fractional allele loss correlates with survival

1995 • 124 citations

Chromosomal abnormalities involving 11q13 are associated with poor prognosis in patients with squamous cell carcinoma of the head and neck

1995 • 118 citations

Oncogene Amplification in Squamous Cell Carcinoma of the Oral Cavity

1989 • 115 citations

Allelic imbalance on chromosome 3p in oral dysplastic lesions: an early event in oral carcinogenesis.

1996 • 106 citations

The molecular biology of oral carcinogenesis: Toward a tumor progression model

1997 • 102 citations

Genetic changes in intraductal breast cancer detected by comparative genomic hybridization.

1997 • 101 citations

Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas.

1997 • 95 citations

Low-Dose Isotretinoin Versus -Carotene to Prevent Oral Carcinogenesis: Long-term Follow-up

1997 • 94 citations

[22] Detection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization

1995 • 94 citations

Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumours.

1985 • 89 citations

Frequent novel DNA copy number increase in squamous cell head and neck tumors.

1995 • 89 citations

Direct visualization of the clonal progression of primary cutaneous melanoma: application of tissue microdissection and comparative genomic hybridization.

1995 • 87 citations

LOH at 3p correlates with a poor survival in oral squamous cell carcinoma

1996 • 79 citations

Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma

1997 • 79 citations

Comparative genomic hybridisation for the analysis of chromosomal imbalances in solid tumours and haematological malignancies

1997 • 78 citations

Distinct nonrandom patterns of chromosomal aberrations in the progression of squamous cell carcinomas of the head and neck.

1995 • 66 citations

Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics.

1995 • 64 citations

Deletion mapping of the short arm of chromosome 1 identifies a common region of deletion distal to D1S496 in human meningiomas

1997 • 56 citations

Evidence for multiple tumor suppressor genes on chromosome arm 8p in supraglottic laryngeal cancer

1996 • 51 citations

Frequent gene deletions in potentially malignant oral lesions

1996 • 46 citations

Frequent allelic loss at chromosome arm 3p is distinct from genetic alterations of the Von-Hippel Lindau tumor suppressor gene in head and neck cancer.

1996 • 46 citations

Loss of heterozygosity involving the APC gene in oral squamous cell carcinomas

1994 • 45 citations

Frequent Loss of Heterozygosity on Chromosome Arm 18q in Squamous Cell Carcinomas: Identification of 2 Regions of Loss--18q11.1-q12.3 and 18q21.1-q23

1997 • 45 citations

Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumours.

1985 • 38 citations

Homozygous Deletions and Loss of Expression of the CDKN2 gene occur frequently in head and neck squamous cell carcinoma cell lines but infrequently in primary tumors

1995 • 31 citations

Cytogenetic analysis of 11 squamous cell carcinomas of the head and neck

1994 • 30 citations

Interphase cytogenetics and comparative genomic hybridization of human epithelial cancers and precursor lesions

1997 • 25 citations

Leukoplakia: molecular understanding of pre-malignant lesions and implications for clinical management

1997 • 24 citations