The role of TP53 in Cervical carcinogenesis

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Papillomaviruses and cancer: from basic studies to clinical application

2002 • 3,873 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

NATURAL HISTORY OF CERVICAL INTRAEPITHELIAL NEOPLASIA

1967 • 1,370 citations

The IARC TP53 database: New online mutation analysis and recommendations to users

2002 • 1,248 citations

Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer

1998 • 976 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Estimates of the world‐wide prevalence of cancer for 25 sites in the adult population

2001 • 734 citations

Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically

1999 • 712 citations

Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study

2002 • 689 citations

Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study

2002 • 650 citations

The Human Papillomavirus E6 protein and its contribution to malignant progression

2001 • 514 citations

The role of the E6-p53 interaction in the molecular pathogenesis of HPV

1999 • 431 citations

The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300

1999 • 417 citations

The Human Papillomavirus Type 16 E6 Oncoprotein Can Down-Regulate p53 Activity by Targeting the Transcriptional Coactivator CBP/p300

1999 • 325 citations

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

1992 • 313 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

2000 • 238 citations

Inhibition of p53 DNA binding by human papillomavirus E6 proteins

1994 • 214 citations

Viral Oncoproteins Discriminate between p53 and the p53 Homolog p73

1998 • 194 citations

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation

1996 • 189 citations

Alterations of the p53 gene in human primary cervical carcinoma with and without human papillomavirus infection.

1992 • 177 citations

No evidence of correlation between polymorphism at codon 72 of p53 and risk of cervical cancer in Japanese patients with human papillomavirus 16/18 infection.

1998 • 118 citations

p53, p63 and p73 – solos, alliances and feuds among family members

2001 • 116 citations

Biochemical epidemiology of cervical neoplasia: measuring cigarette smoke constituents in the cervix.

1987 • 115 citations

p53 codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer development.

2001 • 111 citations

Analysis of the p53 gene in human uterine carcinoma cell lines.

1991 • 105 citations

p53 polymorphism in codon 72 and risk of human papillomavirus-induced cervical cancer: effect of inter-laboratory variation

2000 • 97 citations

Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva

1995 • 92 citations

p53 mutations in HPV-negative cervical carcinoma.

1994 • 84 citations

Risk factors for in situ cervical cancer: results from a case-control study.

1990 • 75 citations

Genetic alterations of the TP53 gene, p53 protein expression and hpv infection in primary cervical carcinomas

1993 • 74 citations

Functional inactivation of p73, a homolog of p53 tumor suppressor protein, by human papillomavirus E6 proteins

2001 • 73 citations

p53 mutations in cervical carcinogenesis – low frequency and lack of correlation with human papillomavirus status

1994 • 70 citations

p53 codon 72 polymorphism and risk of intra-epithelial and invasive cervical neoplasia in Greek women

2000 • 61 citations

Risk factors for progression of cervical intraepithelial neoplasm grade III to invasive cervical cancer.

1995 • 59 citations

The status of the p⁵³ gene in human papilloma virus positive or negative cervical carcinoma cell lines

1992 • 47 citations

Correlation between HPV Positivity and State of the p53 Gene in Cervical Carcinoma Cell Lines

1993 • 30 citations

p53 mutations are rare events in recurrent cervical cancer

2001 • 24 citations

Human Papillomavirus Infection and TP53 Gene Mutation in Primary Cervical Carcinoma

1997 • 21 citations

Elderly Japanese women with cervical carcinoma show higher proportions of both intermediate-risk human papillomavirus types and p53 mutations

1999 • 14 citations

Higher incidence of p53 mutation in cervical carcinomas with intermediate-risk HPV infection

2001 • 10 citations

Early Genes of Human Papillomaviruses

2006 • 3 citations