Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

p-Chlorophenylalanine: a specific depletor of brain serotonin.

1966 • 1,754 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Is the forced swimming test a suitable model for revealing antidepressant activity?

1988 • 1,053 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site

1983 • 869 citations

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT

1983 • 759 citations

The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-Propylamino) tetralin in the rat

1984 • 678 citations

Discrimination of Multiple [³H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain

1981 • 629 citations

The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site

1984 • 598 citations

Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents

1984 • 597 citations

Immobility induced by forced swimming in rats: Effects of agents which modify central catecholamine and serotonin activity

1979 • 576 citations

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

1979 • 426 citations

Zur Serotonin-Hypothese der Depression*

1990 • 397 citations

Specificity of the learned helplessness model of depression

1982 • 383 citations

Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors

1985 • 367 citations

Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens

1988 • 334 citations

Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.

1984 • 324 citations

Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression

1987 • 230 citations

Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

1984 • 221 citations

Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors.

1987 • 217 citations

Deficits of escape performance following catecholamine depletion: Implications for behavioral deficits induced by uncontrollable stress

1979 • 196 citations

Serotonergic mechanisms in the behavioral effects of buspirone and gepirone

1986 • 194 citations

Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity.

1989 • 189 citations

Double-blind comparative trials of fluoxetine and doxepin in geriatric patients with major depressive disorder.

1985 • 170 citations

8-OH-DPAT-induced hyperphagia: Its neural basis and possible therapeutic relevance

1986 • 167 citations

Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist

1987 • 163 citations

Effects of antidepressants in the rat forced swimming test

1981 • 160 citations

A double-blind controlled clinical trial of fluoxetine and amitriptyline in the treatment of outpatients with major depressive disorder.

1985 • 156 citations

Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821

1984 • 138 citations

1-(2-Pyrimidinyl)-Piperazine as Active Metabolite of Buspirone in Man and Rat

1986 • 117 citations

Reversal of helpless behavior in rats by putative 5-HT1A agonists

1988 • 108 citations

[³H]5‐Hydroxytryptamine Binding Sites: Species and Tissue Variation

1984 • 105 citations

Differential-reinforcement-of-low-rate 72-second schedule: selective effects of antidepressant drugs.

1983 • 103 citations

Serotonin and its place in the pathogenesis of depression.

1988 • 102 citations

Pharmacological properties of SM-3997: A new anxioselective anxiolytic candidate.

1987 • 86 citations

Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: Evidence that this model identifies anxiolytic-like activity

1989 • 84 citations

8-Hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin1A receptor agonist, reduces the immobility of rats in the forced swimming test by acting on the nucleus raphe dorsalis

1988 • 84 citations

Open trial of buspirone in the treatment of major depressive disorder.

1986 • 83 citations

Evidence for involvement of 5-hydroxytryptamine1 receptors in antidepressant-like drug effects on differential-reinforcement-of-low-rate 72-second behavior.

1989 • 81 citations

Reduction of feeding behavior by the serotonin uptake inhibitor sertraline

1988 • 78 citations

Sertraline, a selective inhibitor of serotonin uptake, for the treatment of outpatients with major depressive disorder.

1988 • 69 citations

Buspirone as a midbrain modulator: Anxiolysis unrelated to traditional benzodiazepine mechanisms

1984 • 68 citations

Blockade of α2-adrenoceptors by 1-(2-pyrimidinyl)-piperazine (PmP) in vivo and its relation to the activity of buspirone

1988 • 57 citations

Behavioral effects of several new anxiolytics and putative anxiolytics

1987 • 57 citations

Different effects of intracerebral and systemic administration of buspirone in the forced swimming test: Involvement of a metabolite

1988 • 50 citations

The lesion of serotonergic neurons does not prevent antidepressant-induced reversal of escape failures produced by inescapable shocks in rats

1986 • 50 citations

Characterization of the putative anxiolytic SM-3997 recognition sites in rat brain.

1988 • 41 citations

Properties of mercury and selenium in a high-molecular weight substance in rabbit tissues formed by simulataneous administration

1981 • 41 citations

2-Pyrrolidinone and succinimide endogenously present in several mammalian species

1984 • 27 citations

A comparative pharmacological study of trazodone, etoperidone and 1-(m-chlorophenyl)piperazine.

1984 • 16 citations

Deleted Work

1955 • 0 citations