Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis

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2000 • 27,569 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1997 • 2,746 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Growth Factors and Cancer

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Delineation of prognostic biomarkers in prostate cancer

2001 • 1,694 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN

1998 • 1,215 citations

The Multiple Roles of PTEN in Tumor Suppression

2000 • 1,150 citations

Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems

1999 • 941 citations

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1997 • 778 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

Pten Dose Dictates Cancer Progression in the Prostate

2003 • 665 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

The Role of Increasing Detection in the Rising Incidence of Prostate Cancer

1995 • 642 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

1999 • 631 citations

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

1999 • 539 citations

Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease.

2002 • 519 citations

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

1997 • 464 citations

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

2000 • 430 citations

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.

1998 • 388 citations

Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression

2000 • 381 citations

Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease.

2002 • 371 citations

PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1999 • 367 citations

Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.

1999 • 365 citations

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice.

2000 • 355 citations

Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN

2004 • 338 citations

Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling Pathways

1998 • 336 citations

Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium.

1996 • 162 citations

Tyrosine Kinases Expressed in Vivo by Human Prostate Cancer Bone Marrow Metastases and Loss of the Type 1 Insulin-Like Growth Factor Receptor

1999 • 162 citations

Expression of the epidermal growth factor receptor family in prostate carcinoma before and during androgen-independence

2004 • 162 citations

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

2004 • 159 citations

Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN

1998 • 157 citations

PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells

2004 • 142 citations

Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin- like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium

1996 • 90 citations

IMMUNOHISTOCHEMICAL COMPARATIVE ANALYSIS OF TRANSFORMING GROWTH FACTOR α, EPIDERMAL GROWTH FACTOR, AND EPIDERMAL GROWTH FACTOR RECEPTOR IN NORMAL, HYPERPLASTIC AND NEOPLASTIC HUMAN PROSTATES

1999 • 87 citations

Epidermal growth factor-related peptides and the epidermal growth factor receptor in normal and malignant prostate

1995 • 87 citations

Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies

2004 • 83 citations

Distinct Involvement of β3 Integrin Cytoplasmic Domain Tyrosine Residues 747 and 759 in Integrin-mediated Cytoskeletal Assembly and Phosphotyrosine Signaling

1998 • 77 citations

Blockade of the type I IGF receptor expression in human prostate cancer cells inhibits proliferation and invasion, up‐regulates IGF binding protein‐3, and suppresses MMP‐2 expression

2003 • 76 citations

Comparative analysis of mrna and protein expression for epidermal growth factor receptor and ligands relative to the proliferative index in human prostate tissue

1996 • 74 citations

MITOGENIC SIGNALING IN ANDROGEN SENSITIVE AND INSENSITIVE PROSTATE CANCER CELL LINES

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Emerging targets in the AKT pathway for treatment of androgen-independent prostatic adenocarcinoma

2002 • 65 citations

Chromosome 10 alterations in prostate adenocarcinoma (review).

1998 • 61 citations

Cell-cycle dysregulation and the molecular mechanisms of prostate cancer

2000 • 53 citations

Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue

1994 • 49 citations

Mutations of PTEN/MMAC1 in primary prostate cancers from Chinese patients.

2001 • 45 citations

The localization of transforming growth factor alpha and epidermal growth factor receptor in stromal and epithelial compartments of developing human prostate and hyperplastic, dysplastic, and carcinomatous lesions

1998 • 38 citations

Histopathology of prostate carcinoma diagnosis and differential diagnosis

1985 • 26 citations

Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor

2002 • 20 citations

ILK as a potential marker gene to ascertain specific adenocarcinoma cell mRNA isolation from frozen prostate biopsy tissue sections

2005 • 9 citations