Synergistic anti-tumor effects with co-expression of GM-CSF and IFN-γ in murine tumors

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

1988 • 1,325 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Murine interleukin-4 displays potent anti-tumor activity in vivo

1989 • 790 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Down-Regulation of the Antitumor Immune Response

1985 • 676 citations

Retroviral vector-mediated gamma-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity.

1990 • 414 citations

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

1991 • 333 citations

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

1994 • 319 citations

Granulocyte-macrophage-colony-stimulating factor enhances immune responses to melanoma-associated peptidesin vivo

1996 • 308 citations

The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.

1991 • 235 citations

IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells.

1989 • 234 citations

Combination gene therapy for liver metastasis of colon carcinoma in vivo.

1995 • 222 citations

Antitumor effects of granulocyte-macrophage colony-stimulating factor production by melanoma cells.

1996 • 112 citations

Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro.

1988 • 101 citations

Immunotherapy of bladder cancer with cytokine gene-modified tumor vaccines.

1994 • 95 citations

Potent activation of mouse macrophages by recombinant interferon-gamma.

1984 • 89 citations

Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes.

1987 • 84 citations

Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression.

1991 • 55 citations

Retroviral Gene Transfer Using Safe and Efficient Packaging Cell Lines

1990 • 42 citations

The effect of combined expression of interleukin 2 and interleukin 4 on the tumorigenicity and treatment of B16F10 melanoma

1996 • 19 citations

A Retroviral Vector That Allows Efficient Co-Expression of Two Genes and the Versatility of Alternate Selection Markers

1997 • 16 citations

Comparison of the potential therapeutic effects of interleukin 2 or interleukin 4 secretion by a single tumour

1993 • 14 citations