A decade of progress in statistical methodology for clinical trials

Meta-analysis in clinical trials

1986 • 36,193 citations

Classification and Regression Trees.

1984 • 23,117 citations

Statistical Methods for Meta-Analysis

1988 • 10,595 citations

The Jackknife, the Bootstrap and Other Resampling Plans

1982 • 7,816 citations

Bootstrap Methods for Standard Errors, Confidence Intervals, and Other Measures of Statistical Accuracy

1986 • 6,027 citations

Optimal two-stage designs for phase II clinical trials

1989 • 3,494 citations

Survival Analysis

1981 • 3,421 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

Generalized Additive Models

1986 • 3,141 citations

Single Case Experimental Designs: Strategies for Studying Behavior Change

1976 • 3,056 citations

Single-Case Research Designs: Methods for Clinical and Applied Settings

1982 • 2,700 citations

Partial residuals for the proportional hazards regression model

1982 • 2,578 citations

Bayesian Inference for Causal Effects: The Role of Randomization

1978 • 2,427 citations

Flexible regression models with cubic splines

1989 • 2,398 citations

Sequential Treatment Assignment with Balancing for Prognostic Factors in the Controlled Clinical Trial

1975 • 2,224 citations

Confidence intervals rather than P values: estimation rather than hypothesis testing.

1986 • 1,947 citations

Surrogate endpoints in clinical trials: Definition and operational criteria

1989 • 1,929 citations

Discrete sequential boundaries for clinical trials

1983 • 1,710 citations

Group sequential methods in the design and analysis of clinical trials

1977 • 1,679 citations

Discrete Sequential Boundaries for Clinical Trials

1983 • 1,584 citations

Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer

1990 • 1,503 citations

A method for assessing the quality of a randomized control trial

1981 • 1,370 citations

Cross-Validation of Regression Models

1984 • 1,362 citations

Meta-Analyses of Randomized Controlled Trials

1987 • 1,278 citations

Summing Up

1984 • 1,276 citations

Procedures for Comparing Samples with Multiple Endpoints

1984 • 1,166 citations

A class of rank test procedures for censored survival data

1982 • 1,111 citations

Analysis of survival by tumor response.

1983 • 1,021 citations

Analysis of survival by tumor response.

1986 • 1,018 citations

Some Aspects of the Spline Smoothing Approach to Non-Parametric Regression Curve Fitting

1985 • 1,015 citations

Introduction to sample size determination and power analysis for clinical trials

1981 • 996 citations

One-Sample Multiple Testing Procedure for Phase II Clinical Trials

1982 • 987 citations

Sample-Size Formula for the Proportional-Hazards Regression Model

1983 • 940 citations

A Network Algorithm for Performing Fisher's Exact Test inr×cContingency Tables

1983 • 916 citations

Regression Models in Clinical Studies: Determining Relationships Between Predictors and Response

1988 • 888 citations

Logistic Regression, Survival Analysis, and the Kaplan-Meier Curve

1988 • 886 citations

Design and Analysis of Phase I Clinical Trials

1989 • 882 citations

“Proving the null hypothesis” in clinical trials

1982 • 870 citations

Minimization: A new method of assigning patients to treatment and control groups

1974 • 837 citations

A Confidence Interval for the Median Survival Time

1982 • 831 citations

Bivariate Survival Models Induced by Frailties

1989 • 793 citations

The Use of Mixture Models for the Analysis of Survival Data with Long-Term Survivors

1982 • 785 citations

Publication Bias: A Problem in Interpreting Medical Data

1988 • 773 citations

Publication bias and clinical trials

1987 • 715 citations

Tables of the number of patients required in clinical trials using the logrank test

1982 • 694 citations

A linear regression model for the analysis of life times

1989 • 678 citations

Survival models for heterogeneous populations derived from stable distributions

1986 • 669 citations

Statistical Problems in the Reporting of Clinical Trials

1987 • 663 citations

A Proportional Hazards Model for Interval-Censored Failure Time Data

1986 • 648 citations

Biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates

1984 • 647 citations

Censored Data and the Bootstrap

1981 • 639 citations

Testing for Qualitative Interactions between Treatment Effects and Patient Subsets

1985 • 638 citations

Multivariate Generalizations of the Proportional Hazards Model

1985 • 595 citations

Bandit problems

1985 • 578 citations

Regression models for prognostic prediction: advantages, problems, and suggested solutions.

1985 • 554 citations

Determining Optimal Therapy — Randomized Trials in Individual Patients

1986 • 547 citations

The Analysis of Multiple Endpoints in Clinical Trials

1987 • 528 citations

Reporting on Methods in Clinical Trials

1982 • 503 citations

A Network Algorithm for Performing Fisher's Exact Test in r × c Contingency Tables

1983 • 485 citations

Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

1985 • 483 citations

Randomized phase II clinical trials.

1985 • 469 citations

A Model for Association in Bivariate Survival Data

1982 • 461 citations

Chi-squared goodness-of-fit tests for the proportional hazards regression model

1980 • 458 citations

The asymptotic properties of nonparametric tests for comparing survival distributions

1981 • 453 citations

Analysis of data from multiclinic trials

1986 • 443 citations

A comparison of statistical methods for combining event rates from clinical trials

1989 • 426 citations

Confidence Intervals for Reporting Results of Clinical Trials

1986 • 425 citations

Publication Bias and Dissemination of Clinical Research

1989 • 418 citations

Life table methods for heterogeneous populations: Distributions describing the heterogeneity

1984 • 415 citations

Flexible Parsimonious Smoothing and Additive Modeling

1989 • 403 citations

Selection Models and the File Drawer Problem

1988 • 392 citations

Guidelines for Statistical Reporting in Articles for Medical Journals

1988 • 392 citations

Evaluation of Sample Size and Power for Analyses of Survival with Allowance for Nonuniform Patient Entry, Losses to Follow-Up, Noncompliance, and Stratification

1986 • 380 citations

The Crossover Experiment for Clinical Trials

1980 • 374 citations

Heterogeneity in survival analysis

1988 • 367 citations

Designs for group sequential tests

1984 • 352 citations

Stochastically curtailed tests in long–term clinical trials

1982 • 345 citations

A non-parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non-responder bias

1984 • 344 citations

Exact Significance Testing to Establish Treatment Equivalence with Ordered Categorical Data

1984 • 343 citations

Nomograms for Calculating the Number of Patients Needed for a Clinical Trial with Survival as an Endpoint

1982 • 338 citations

Computing an Exact Confidence Interval for the Common Odds Ratio in Several 2×2 Contingency Tables

1985 • 337 citations

Approximately Optimal One-Parameter Boundaries for Group Sequential Trials

1987 • 334 citations

Sample Sizes Based on the Log-Rank Statistic in Complex Clinical Trials

1988 • 330 citations

Bootstrap investigation of the stability of a cox regression model

1989 • 306 citations

A Markov Model for Analysing Cancer Markers and Disease States in Survival Studies

1986 • 299 citations

Regression with censored data

1982 • 294 citations

Computing Distributions for Exact Logistic Regression

1987 • 291 citations

Design and analysis of group sequential tests based on the type I error spending rate function

1987 • 287 citations

Weighted Kaplan-Meier Statistics: A Class of Distance Tests for Censored Survival Data

1989 • 286 citations

Tree-structured survival analysis.

1985 • 281 citations

Monitoring clinical trials: Conditional or predictive power?

1986 • 281 citations

Multivariate Methods in Ophthalmology with Application to Other Paired-Data Situations

1984 • 268 citations

A predictive approach to selecting the size of a clinical trial, based on subjective clinical opinion

1986 • 268 citations

Covariate imbalance and random allocation in clinical trials

1989 • 266 citations

Randomization in clinical trials: Conclusions and recommendations

1988 • 265 citations

Optimum biased coin designs for sequential clinical trials with prognostic factors

1982 • 265 citations

Planning the duration of a comparative clinical trial with loss to follow-up and a period of continued observation

1981 • 264 citations

Interim Analyses for Randomized Clinical Trials: The Group Sequential Approach

1982 • 261 citations

Approaches to sample size estimation in the design of clinical trials—a review

1984 • 251 citations

Testing Goodness of Fit of Cox's Regression and Life Model

1982 • 246 citations

On the bias of maximum likelihood estimation following a sequential test

1986 • 238 citations

Modified Kolmogorov-Smirnov Test Procedures with Application to Arbitrarily Right-Censored Data

1980 • 237 citations

Modelling Paired Survival Data with Covariates

1989 • 236 citations

Surrogate endpoints in clinical trials: Cardiovascular diseases

1989 • 235 citations

Sample size requirements for evaluating a conservative therapy.

1978 • 228 citations

Two-Sample Repeated Significance Tests Based on the Modified Wilcoxon Statistic

1982 • 228 citations

Exact Unconditional Sample Sizes for the 2 × 2 Binomial Trial

1985 • 225 citations

Exact Confidence Intervals Following a Group Sequential Test

1984 • 224 citations

A Treatment Allocation Procedure for Sequential Clinical Trials

1980 • 221 citations

Confronting publication bias: A cohort design for meta‐analysis

1987 • 220 citations

A Semiparametric Model for Regression Analysis of Interval-Censored Failure Time Data

1985 • 220 citations

Dynamic Graphics for Data Analysis

1987 • 219 citations

Interim Analyses: The Repeated Confidence Interval Approach

1989 • 211 citations

Estimating a Population of Parameter Values Using Bayes and Empirical Bayes Methods

1984 • 210 citations

Reporting standards and research strategies for controlled trials

1980 • 205 citations

Interim Analyses in Randomized Clinical Trials: Ramifications and Guidelines for Practitioners

1987 • 200 citations

An aid to data monitoring in long-term clinical trials

1982 • 200 citations

Two-stage selection and testing designs for comparative clinical trials

1988 • 194 citations

Group sequential methods for clinical trials with a one-sided hypothesis

1980 • 192 citations

Group Sequential Clinical Trials with Triangular Continuation Regions

1983 • 191 citations

The Design and Analysis of Sequential Clinical Trials.

1983 • 190 citations

Measures of explained variation for survival data

1990 • 186 citations

Exponential survival trees

1989 • 184 citations

Properties of Proportional-Hazards Score Tests under Misspecified Regression Models

1984 • 183 citations

Measuring and analysing quality of life in cancer clinical trials: A review

1983 • 179 citations

A simple test of the proportional hazards assumption

1987 • 176 citations

A Two-Stage Design for Choosing among Several Experimental Treatments and a Control in Clinical Trials

1989 • 173 citations

A Quality-of-Life-Oriented Endpoint for Comparing Therapies

1989 • 172 citations

Quality of life assessment in clinical trials: Methodologic issues

1989 • 169 citations

Restricted Randomization Designs in Clinical Trials

1979 • 168 citations

Investigating Therapies of Potentially Great Benefit: ECMO

1989 • 168 citations

Sample Size for Testing Differences in Proportions for the Paired-Sample Design

1987 • 168 citations

Bayesian Methods in Practice: Experiences in the Pharmaceutical Industry

1986 • 167 citations

Interaction

1984 • 165 citations

A critique of recent research on the two-treatment crossover design

1989 • 162 citations

The asymptotic joint distribution of the efficient scores test for the proportional hazards model calculated over time

1981 • 160 citations

Censoring distributions as a measure of follow‐up in survival analysis

1986 • 160 citations

Computing an Exact Confidence Interval for the Common Odds Ratio in Several 2 × 2 Contingency Tables

1985 • 156 citations

Sequential analysis of the proportional hazards model

1983 • 156 citations

Surrogate endpoints in clinical trials: Cancer

1989 • 154 citations

Practical problems in interim analyses, with particular regard to estimation

1989 • 153 citations

Measures of dependence for censored survival data

1988 • 152 citations

Repeated confidence intervals for group sequential clinical trials

1984 • 148 citations

Testing Whether an Identified Treatment Is Best

1989 • 148 citations

Treatment allocation methods in clinical trials: A review

1985 • 145 citations

A Graphical Method for Assessing Goodness of Fit in Cox's Proportional Hazards Model

1988 • 144 citations

Symmetric Group Sequential Test Designs

1989 • 142 citations

Confidence Intervals for a Binomial Parameter Based on Multistage Tests

1987 • 141 citations

Semiparametric inference in a model for association in bivanate survival data

1986 • 139 citations

Estimating the median survival time

1981 • 138 citations

Sequential medical trials

1961 • 138 citations

A Global Goodness-of-Fit Statistic for the Proportional Hazards Model

1985 • 137 citations

Designs for Group Sequential Phase II Clinical Trials

1987 • 136 citations

Asymmetric group sequential boundaries for monitoring clinical trials

1982 • 134 citations

Predictive Probability Early Termination Plans For Phase II Clinical Trials

1979 • 133 citations

Approximate Case Influence for the Proportional Hazards Regression Model with Censored Data

1984 • 133 citations

What Price Kaplan-Meier?

1983 • 131 citations

Patient subsets and variation in therapeutic efficacy.

1982 • 130 citations

Adaptive Treatment Assignment Methods and Clinical Trials

1977 • 126 citations

Multistate models in survival analysis: A study of nephropathy and mortality in diabetes

1988 • 125 citations

An Assessment of Publication Bias Using a Sample of Published Clinical Trials

1989 • 125 citations

Changing Frequency of Interim Analysis in Sequential Monitoring

1989 • 124 citations

Meta‐analysis of clinical trials as a scientific discipline. II: Replicate variability and comparison of studies that agree and disagree

1987 • 124 citations

Survivorship analysis when cure is a possibility: A monte carlo study

1984 • 122 citations

Sequential Treatment Allocation Using Biased Coin Designs

1984 • 121 citations

Comparison of Bayesian with group sequential methods for monitoring clinical trials

1989 • 121 citations

The 2 × 2 factorial design: Its application to a randomized trial of aspirin and U.S. physicians

1985 • 120 citations

Considerations for the meta-analysis of randomized clinical trials

1989 • 119 citations

Analysis of survival data with nonproportional hazard functions

1981 • 118 citations

Towards a reduction in publication bias.

1987 • 118 citations

Testing Goodness of Fit for Proportional Hazards Model with Censored Observations

1984 • 117 citations

Methodologic guidelines for reports of clinical trials.

1985 • 117 citations

An Algorithm for Finding the Exact Significance Levels ofr×cContingency Tables

1981 • 115 citations

Stopping rules and estimation problems in clinical trials

1988 • 114 citations

The explained variation in proportional hazards regression

1990 • 114 citations

Statistical aspects of early termination in the beta-blocker heart attack trial

1984 • 112 citations

Supremum Versions of the Log-Rank and Generalized Wilcoxon Statistics

1987 • 111 citations

Contrasts for Identifying the Minimum Effective Dose

1989 • 111 citations

The Assessment of the Subjective Opinion and its Use in Relation to Stopping Rules for Clinical Trials

1983 • 110 citations

Extended Hazard Regression for Censored Survival Data with Covariates: A Spline Approximation for the Baseline Hazard Function

1987 • 108 citations

Interim analyses in clinical trials: Classical vs. bayesian approaches

1985 • 108 citations

Confidence Intervals for a Binomial Parameter Following a Multistage Test With Application to MIL-STD 105D and Medical Trials

1983 • 107 citations

Clinical trial methodology

1978 • 106 citations

A linear rank test for use when the main interest is in differences in cure rates.

1989 • 106 citations

Sample size determination in clinical trials with time-dependent rates of losses and noncompliance

1986 • 105 citations

A Two-Sample Censored-Data Rank Test for Acceleration

1984 • 105 citations

Interim Analysis in Clinical Trials: The Role of the Likelihood Principle

1987 • 105 citations

A Paired Prentice-Wilcoxon Test for Censored Paired Data

1987 • 103 citations

Nonparametric confidence limits for survival probabilities and median survival time.

1982 • 103 citations

One-Sided Sequential Stopping Boundaries for Clinical Trials: A Decision- Theoretic Approach

1988 • 102 citations

A measure to aid in the interpretation of published clinical trials

1985 • 102 citations

Evaluating Serial Cancer Marker Studies in Patients at Risk of Recurrent Disease

1981 • 102 citations

Influence functions for proportional hazards regression

1985 • 99 citations

Choosing covariates in the analysis of clinical trials

1989 • 99 citations

A comparison of estimated proportional hazards models and regression trees

1989 • 97 citations

Confidence Limits for Probability of Response in Multistage Phase II Clinical Trials

1985 • 97 citations

The analysis of event history data: A review of progress and outstanding problems

1988 • 96 citations

Dependent competing risks and summary survival curves

1983 • 96 citations

How large should a phase II trial of a new drug be?

1987 • 96 citations

Planning and Monitoring of Equivalence Studies

1990 • 96 citations

A Monte Carlo Study of Some Two-Sample Rank Tests with Censored Data

1981 • 95 citations

Smooth Estimates for the Hazard Function

1980 • 94 citations

Confidence intervals following group sequential tests

1986 • 94 citations

P values for tests using a repeated significance test design

1982 • 92 citations

Nonparametric analysis of an accelerated failure time model

1981 • 92 citations

A Simple Approximation for Calculating Sample Sizes for Detecting Linear Trend in Proportions

1987 • 90 citations

Stopping Rules for Clinical Trials Incorporating Clinical Opinion

1984 • 90 citations

Practical aspects in data monitoring: A brief review

1987 • 89 citations

Sample size and power determination for stratified clinical trials

1978 • 89 citations

A Linear Rank Test for Use When the Main Interest Is in Differences in Cure Rates

1989 • 89 citations

Assessing apparent treatment—covariate interactions in randomized clinical trials

1985 • 88 citations

Factorial designs for randomized clinical trials.

1985 • 88 citations

A Diagnostic for Cox Regression and General Conditional Likelihoods

1985 • 88 citations

Guidelines for publishing papers on cancer clinical trials: responsibilities of editors and authors.

1983 • 85 citations

A Comparison of Reflected Versus Test-Based Confidence Intervals for the Median Survival Time, Based on Censored Data

1984 • 85 citations

Exact two-sample permutation tests based on the randomized play-the-winner rule

1988 • 84 citations

Group sequential tests with censored survival data adjusting for covariates

1985 • 84 citations

Early decision in clinical trials when the treatment differences are small

1985 • 84 citations

The graphical evaluation of explanatory variables in proportional hazard regression models

1981 • 83 citations

The impact of heterogeneity on the comparison of survival times

1987 • 82 citations

Approximate Confidence Intervals for Probabilities of Survival and Quantiles in Life-Table Analysis

1982 • 82 citations

Confidence Intervals Following Group Sequential Tests in Clinical Trials

1987 • 82 citations

Design of Group Sequential Clinical Trials with Multiple Endpoints

1989 • 81 citations

The impact that group sequential tests would have made on ECOG clinical trials

1989 • 81 citations

Incorporating historical control data in planning phase II clinical trials

1990 • 81 citations

Design of Group Sequential Clinical Trials with Multiple Endpoints

1989 • 81 citations

Carryover and the two-period crossover clinical trial.

1986 • 81 citations

Rank tests for censored matched pairs

1980 • 80 citations

A hybrid algorithm for fisher's exact test in unordered rxc contingency tables

1986 • 79 citations

Recent Results in Cancer Research

1987 • 78 citations

Regression and recursive partition strategies in the analysis of medical survival data

1988 • 76 citations

Sample size graphs for “proving the null hypothesis”

1984 • 76 citations

Adaptive allocation in randomized controlled trials

1985 • 76 citations

Sample size considerations for non-randomized comparative studies

1980 • 76 citations

Sequential Linear Rank Tests for Two-Sample Censored Survival Data

1984 • 76 citations

Comparing survival of responders and nonresponders after treatment: A potential source of confusion in interpreting cancer clinical trials

1983 • 76 citations

Carryover and the Two-Period Crossover Clinical Trial

1986 • 75 citations

Comparison of Several Treatments with a Control Using Multiple Contrasts

1987 • 74 citations

Sample size considerations for studies comparing survival curves using historical controls

1988 • 74 citations

Effective sample sizes for confidence intervals for survival probabilities

1987 • 74 citations

Conditional power calculations as an aid in the decision whether to continue a clinical trial

1987 • 74 citations

Nonparametric Inference for a Class of Semi-Markov Processes with Censored Observations

1984 • 73 citations

A General Class of Nonparametric Tests for Survival Analysis

1989 • 73 citations

Monitoring Clinical Trials Based on Predictive Probability of Significance

1989 • 72 citations

Sample sizes for constructing confidence intervals and testing hypotheses

1989 • 72 citations

Sample sizes for long-term medical trial with time-dependent dropout and event rates

1980 • 71 citations

Supplementary Analysis at the Conclusion of a Sequential Clinical Trial

1986 • 71 citations

A Two-Sample Test Sensitive to Crossing Hazards in Uncensored and Singly Censored Data

1985 • 68 citations

Efficient group sequential tests with unpredictable group sizes

1987 • 68 citations

An efficient design for phase III studies of combination chemotherapies.

1985 • 67 citations

Confidence Intervals for a Normal Mean Following a Group Sequential Test

1989 • 67 citations

On choosing the number of interim analyses in clinical trials

1982 • 66 citations

Importance Sampling for Estimating Exact Probabilities in Permutational Inference

1988 • 66 citations

Ak-Sample Median Test for Censored Data

1982 • 65 citations

Sample size requirements for comparing time-to-failure among k treatment groups

1982 • 65 citations

Stopping guidelines vs stopping rules: a practitioner's point of view

1984 • 65 citations

Factorial designs in clinical trials: The effects of non‐compliance and subadditivity

1989 • 64 citations

Constructing exact significance tests with restricted randomization rules

1988 • 63 citations

Analysis of clinical trial outcomes: Some comments on subgroup analyses

1989 • 63 citations

Monitoring Accumulating Data in a Clinical Trial

1989 • 63 citations

Nonparametric Confidence Intervals for the Median in the Presence of Right Censoring

1982 • 62 citations

A general model for testing the proportional hazards and the accelerated failure time hypotheses in the analysis of censored survival data with covariates

1985 • 62 citations

On the Distribution of the Maximum of the Logrank Statistic and the Modified Wilcoxon Statistic

1981 • 62 citations

A Bayesian Approach to the Design of Phase II Clinical Trials

1988 • 62 citations

$K$-Treatment Comparisons with Restricted Randomization Rules in Clinical Trials

1986 • 58 citations

An Algorithm for Finding the Exact Significance Levels of r × c Contingency Tables

1981 • 58 citations

On the Allocation of Treatments in Sequential Medical Trials

1985 • 58 citations

Sample sizes for phase II and phase III clinical trials: An integrated approach

1986 • 58 citations

Monitoring of the data for evidence of adverse or beneficial treatment effects

1983 • 57 citations

A Simple Test for Goodness of Fit of Cox's Proportional Hazards Model

1984 • 57 citations

Estimation of the Proportional Hazard in Two-Treatment-Group Clinical Trials

1981 • 57 citations

Recent Developments in Crossover Designs

1988 • 56 citations

Group sequential methods for clinical trials allowing early acceptance of H_o and incorporating costs

1982 • 56 citations

Some Issues in the Design and Interpretation of 'Negative' Clinical Studies

1986 • 56 citations

Use of Logrank Tests and Group Sequential Methods at Fixed Calendar Times

1985 • 56 citations

Methodologic Guidelines for Reports of Clinical Trials

1986 • 55 citations

Semiparametric Inference in a Model for Association in Bivariate Survival Data

1986 • 55 citations

Meta-analysis: Science or religion?

1989 • 54 citations

Designing clinical trials with arbitrary specification of survival functions and for the log rank or generalized Wilcoxon test

1987 • 54 citations

Meta-analysis and evidence

1989 • 54 citations

Interaction between prognostic factors and treatment

1983 • 53 citations

Randomized Allocation of Treatments in Sequential Experiments

1981 • 53 citations

Calibrated phase II clinical trials in oncology

1986 • 52 citations

An Algorithm for Exact Logistic Regression

1984 • 51 citations

Evaluating the efficacy of a combination therapy

1987 • 51 citations

Post-Stratification in the Randomized Clinical Trial

1983 • 50 citations

Repeated confidence intervals for the median survival time

1985 • 50 citations

Treatment Allocation for Nonlinear Models in Clinical Trials: The Logistic Model

1984 • 49 citations

On Approximate Sample Sizes for Comparing Two Independent Proportions with the Use of Yates' Correction

1980 • 49 citations

Surrogate endpoints in clinical trials: Ophthalmologic disorders

1989 • 47 citations

Empirical Bayes estimates of subgroup effects in clinical trials

1990 • 46 citations

Omitting Covariates from the Proportional Hazards Model

1986 • 45 citations

Rank tests for association with right censored data

1982 • 45 citations

Statistics in medical journals: A survey of current policies and proposals for editors

1985 • 44 citations

Sensitivity and Specificity of a Monitoring Test

1985 • 44 citations

A k-Sample Median Test for Censored Data

1982 • 43 citations

Point Estimation Following Group Sequential Tests

1989 • 42 citations

Randomized clinical trials and research strategy.

1982 • 41 citations

An overview of sequential methods and their application in clinical trials

1984 • 41 citations

A Generalized Gehan and Gilbert Test for Paired Observations that are Subject to Arbitrary Right Censorship

1980 • 41 citations

Considerations for monitoring and evaluating treatment effects in clinical trials

1984 • 41 citations

A Bayesian approach to the interpretation of subgroup results in clinical trials

1982 • 40 citations

Partitioning methods for classification and decision making in medicine

1986 • 40 citations

Interim Analysis in Clinical Trials: The Role of the Likelihood Principle

1987 • 39 citations

Prognostic factors and risk groups: Some results given by using an algorithm suitable for censored survival data

1983 • 38 citations

A note on semi-Markov models for partially censored data

1986 • 38 citations

Effect of Categorizing a Continuous Covariate on the Comparison of Survival Time

1986 • 38 citations

A Family of Proportional- and Additive-Hazards Models for Survival Data

1983 • 38 citations

Sample size for comparison of changes in the presence of right censoring caused by death, withdrawal, and staggered entry

1988 • 37 citations

The Power of the Mantel—Haenszel Test

1987 • 37 citations

Proposal to outlaw the term "negative trial"

1985 • 37 citations

Multiple Test Procedures in Clinical Dose Finding Studies

1989 • 36 citations

Generalization of the Mantel-Haenszel Estimator to Nonconstant Odds Ratios

1985 • 36 citations

Randomized play the winner clinical trials

1986 • 36 citations

Optimal two‐stage designs for clinical trials with binary response

1988 • 36 citations

Designing Phase II Studies in the Context of a Programme of Clinical Research

1985 • 35 citations

Sequential testing in clinical trials with repeated measurements

1988 • 35 citations

Asymptotic and Exact Power for the McNemar Test and Its Analogue with R Controls Per Case

1984 • 35 citations

Power and Sample Size for a Collection of 2 x 2 Tables

1984 • 34 citations

The delta and epsilon errors in the assessment of cancer clinical trials.

1979 • 34 citations

Designing clinical trials for two-sided multiple comparisons with a control

1989 • 34 citations

The bias of the sample proportion following a group sequential phase II clinical trial

1989 • 34 citations

Sequential treatment allocation procedures in clinical trials‐with particular attention to the analysis of results for the biased coin design

1986 • 33 citations

On D. Schoenfeld's approach for testing the proportional hazards assumption

1986 • 33 citations

Repeated Significance Tests for Clinical Trials with a Fixed Number of Patients and Variable Follow-Up

1985 • 33 citations

Determining the duration of comparative clinical trials while allowing for cure

1985 • 32 citations

Stochastic approximation methods and their use in bioassay and phase i clinical trials

1984 • 32 citations

Cure rate models: Power of the logrank and generalized wilcoxon tests

1987 • 32 citations

An exact unconditional test for the 2 × 2 comparative trial.

1986 • 31 citations

Incorporating scientific, ethical and economic considerations into the design of clinical trials in the pharmaceutical industry: a sequential approach

1984 • 31 citations

Efficiency of Balanced Treatment Allocation for Survival Analysis

1988 • 31 citations

Some test statistics for use in multistate survival analysis

1983 • 31 citations

Sampling and Assignment Mechanisms in Experiments, Surveys and Observational Studies, Correspondent Paper

1988 • 31 citations

Preface

1987 • 31 citations

A design for phase II testing of anticancer agents within a phase III clinical trial

1988 • 30 citations

When can 'non significantly different' treatments be considered as 'equivalent'?

1979 • 30 citations

An exact unconditional test for the 2 × 2 comparative trial.

1986 • 30 citations

Monitoring boundaries for adverse effects in long-term clinical trials

1986 • 29 citations

Confidence estimation and the size of a clinical trial

1984 • 29 citations

Monitoring versus interim analysis of clinical trials: A perspective from the pharmaceutical industry

1989 • 28 citations

The use of surrogate endpoints in clinical trials (an introduction to a series of four papers)

1989 • 28 citations

A two-stage design for randomized trials with binary outcomes

1987 • 28 citations

Consideration of covariates and stratification in sample size determination for survival time studies

1985 • 28 citations

Survival Analysis of Drug Combinations Using a Hazards Model with Time-Dependent Covariates

1980 • 27 citations

Analysis of clinical trial outcomes: Alternative approaches to subgroup analysis

1989 • 27 citations

A modified log rank test for highly stratified data

1987 • 26 citations

Exact Kolmogorov-Type Tests for Left-Truncated and/or Right-Censored Data

1988 • 26 citations

Early stopping in the two-sample problem for bounded random variables

1982 • 25 citations

The determination of practically useful doses of new drugs: Some methodological considerations

1986 • 24 citations

Use of unequal allocation in survival trials

1987 • 24 citations

On the choice of variance for the log rank test

1984 • 24 citations

Sample Size Tables for Bounding Small Proportions

1986 • 24 citations

Regression Analysis of Survival Data in Cancer Chemotherapy.

1984 • 24 citations

The Power of the Mantel-Haenszel Test

1987 • 24 citations

The analysis of a titration study

1987 • 23 citations

An uncontrolled clinical trial—treatment response or spontaneous improvement?

1982 • 23 citations

Gittins Procedures for Bandits with Delayed Responses

1988 • 22 citations

On Randomized Dynamic Allocation Indices for the Sequential Design of Experiments

1980 • 22 citations

Interaction between prognostic factors and treatment

1983 • 22 citations

Issues of efficiency in combining proportions of deaths from several clinical trials

1987 • 21 citations

A Monte Carlo comparison of three up-and-down designs for dose ranging

1983 • 21 citations

Effect of unequal censoring on the size and power of the logrank and Wilcoxon types of tests for survival data

1989 • 21 citations

Post-hoc selection of covariates in randomized experiments

1985 • 21 citations

Optimal restricted two-stage designs

1987 • 20 citations

The analysis of titration studies in phase III clinical trials

1989 • 19 citations

Monitoring rules for stopping accrual in comparative survival studies

1982 • 17 citations

Sample Size and Duration for Cohort Studies of Survival Time with Covariables

1983 • 17 citations

Multistate survival analysis: an application in breast cancer.

1984 • 17 citations

Overviews of randomized clinical trials.

1987 • 17 citations

A simple method of sample size calculation for unequal‐sample‐size designs that use the logrank or t‐test

1987 • 17 citations

Nonparametric Estimation of the Hazard Ratio

1984 • 17 citations

Magnitude and likelihood of loss resulting from non‐stratified randomization

1982 • 17 citations

An application of bayesian analysis to medical follow-up data

1985 • 16 citations

Asymptotically Efficient Two-Step Estimators of the Hazards Ratio for Follow-Up Studies and Survival Data

1985 • 16 citations

Improved approximation for estimation following closed sequential tests

1988 • 16 citations

Nonparametric Estimation of Duration of Accrual and Total Study Length for Clinical Trials

1987 • 16 citations

Estimation of Treatment Difference following a Sequential Clinical Trial

1989 • 15 citations

Sequential Clinical Trials for Normal Variates Using Interval Composite Hypotheses

1981 • 15 citations

Stratified analysis of multivariate clinical data: Application of a mantel‐haenszel approach

1983 • 14 citations

Sample Size Determination in Clinical Trials with an Emphasis on Exponentially Distributed Responses

1987 • 14 citations

Null results in clinical trials: the need for a decision-theory approach

1980 • 14 citations

Rank tests for censored randomized block designs

1981 • 14 citations

The superiority of a drug combination over each of its components

1989 • 14 citations

Further aspects of data analysis

1983 • 14 citations

Multistate Survival Analysis: An Application in Breast Cancer

1984 • 13 citations

The peer review of manuscripts—In need for improvement

1986 • 13 citations

Clinical trials, reviews, and the Journal of Negative Results.

1981 • 12 citations

Required duration and power determinations for historically controlled studies of survival times

1989 • 12 citations

Quick and Simple Approximation of Sample Sizes for Comparing Two Independent Binomial Distributions: Different-Sample-Size Case

1984 • 12 citations

Simultaneous non‐parametric confidence intervals for survival probabilities from censored data

1986 • 11 citations

Prediction Approaches to Sequentially Searching for an Optimal Dose

1989 • 11 citations

KSTAGE: An interactive computer program for designing phase II clinical trials using predictive probability

1982 • 11 citations

Investigating Maximum Power Losses in Survival Studies with Nonstratified Randomization

1985 • 11 citations

Survival Analysis

1982 • 10 citations

Planning the size of survival time clinical trials with allowance for stratification

1988 • 10 citations

Early Stopping for Sequential Restricted Tests of Binomial Distributions

1983 • 10 citations

A note on data monitoring, incomplete data and curtailed testing

1984 • 10 citations

Early stopping for sequential restricted tests of binomial distributions.

1983 • 10 citations

Prediction intervals for survival data

1983 • 9 citations

Group Sequential Methods for Clinical Trials Allowing Early Acceptance of H o and Incorporating Costs

1982 • 9 citations

Effect of covariate measurement error in randomized clinical trials

1987 • 8 citations

Clinical trials as diagnostic tests

1984 • 8 citations

On the regression analysis of tumour recurrence rates

1989 • 8 citations

A Review of Semi-parametric Models for Life Histories

1984 • 7 citations

Comparing the effects of different durations of the same therapy

1988 • 7 citations

Some observations on semi‐markov models for partially censored data

1984 • 7 citations

Conditional Distribution-Free Tests for the Two-Sample Problem in the Presence of Right Censoring

1980 • 7 citations

Discussion: Combination of Data from Randomized Control Trials

1982 • 6 citations

Nonparametric Estimation of the Hazard Ratio

1984 • 5 citations

A clinical trial with an interim analysis

1986 • 5 citations

The exclusion of patients from a clinical trial

1982 • 5 citations

Optimality of random allocation design for the control of accidental bias in sequential experiments

1985 • 5 citations

Effect of censoring on adjusting for covariates in comparison of survival times

1986 • 5 citations

Preface

1988 • 5 citations

Preface

1984 • 4 citations

A one-sided interim analysis with binary outcomes

1988 • 3 citations

A transient state model for analysing ventilatory status in a randomized clinical trial

1987 • 1 citations

Sample sizes for cancer therapy survival studies based on response surface methods

1987 • 1 citations

Deleted Work

1955 • 0 citations