Novel animal-health drug targets from ligand-gated chloride channels

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

2000 • 1,767 citations

Neurobiology of the Caenorhabditis elegans Genome

1998 • 912 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors

2001 • 872 citations

Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III

2000 • 867 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance

1988 • 798 citations

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1994 • 716 citations

One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction

1999 • 619 citations

A point mutation in a Drosophila GABA receptor confers insecticide resistance

1993 • 552 citations

The GABAergic nervous system of Caenorhabditis elegans

1993 • 491 citations

Ion Channels and Synaptic Organization

2000 • 475 citations

The genetics of ivermectin resistance in Caenorhabditis elegans

2000 • 448 citations

Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic

1992 • 420 citations

avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans

1997 • 350 citations

Ivermectin: A Positive Allosteric Effector of the α7 Neuronal Nicotinic Acetylcholine Receptor

1998 • 308 citations

Genes required for GABA function in Caenorhabditis elegans

1993 • 303 citations

The glycine receptor

1997 • 289 citations

Identification of a Drosophila melanogaster Glutamate-gated Chloride Channel Sensitive to the Antiparasitic Agent Avermectin

1996 • 284 citations

Excitatory amino acids

1998 • 257 citations

MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans

2000 • 236 citations

Genetic manipulation of ion channels: A new approach to structure and mechanism

1989 • 223 citations

Molecular biology of insect neuronal GABA receptors

1997 • 219 citations

TheCaenorhabditis elegans unc-49Locus Encodes Multiple Subunits of a Heteromultimeric GABA Receptor

1999 • 211 citations

Cyclodiene Insecticide Resistance: From Molecular to Population Genetics

2000 • 211 citations

Biochemical Sites of Insecticide Action and Resistance

2001 • 211 citations

Ivermectin, an Unconventional Agonist of the Glycine Receptor Chloride Channel

2001 • 199 citations

Excitatory amino acids

1991 • 194 citations

Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin

2000 • 175 citations

Identification of Two Novel Drosophila melanogaster Histamine-gated Chloride Channel Subunits Expressed in the Eye

2002 • 170 citations

Open-reading-frame sequence tags (OSTs) support the existence of at least 17,300 genes in C. elegans

2001 • 162 citations

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor

1999 • 161 citations

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

1994 • 160 citations

Actions of the insecticide fipronil, on dieldrin‐sensitive and ‐resistant GABA receptors of Drosophila melanogaster

1995 • 156 citations

Inhibitory glutamate receptor channels

1996 • 146 citations

Two cDNAs coding for histamine-gated ion channels in D. melanogaster

2001 • 143 citations

Actions of dihydroavermectin B_1α on insect muscle

1985 • 134 citations

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily

2001 • 127 citations

Mutations Affecting the Glycine Receptor Agonist Transduction Mechanism Convert the Competitive Antagonist, Picrotoxin, into an Allosteric Potentiator

1995 • 122 citations

M2 Pore Mutations Convert the Glycine Receptor Channel from Being Anion- to Cation-Selective

2000 • 120 citations

GLC‐3: a novel fipronil and BIDN‐sensitive, but picrotoxinin‐insensitive, L‐glutamate‐gated chloride channel subunit from Caenorhabditis elegans

2001 • 118 citations

Genetic and Biochemical Evidence for a Novel Avermectin-sensitive Chloride Channel in Caenorhabditis elegans

1997 • 117 citations

From Fruit Flies to Barnacles, Histamine Is the Neurotransmitter of Arthropod Photoreceptors

1999 • 110 citations

Picrotoxin Blockade of Invertebrate Glutamate‐Gated Chloride Channels: Subunit Dependence and Evidence for Binding Within the Pore

1999 • 103 citations

Molecular biology and electrophysiology of glutamategated chloride channels of invertebrates

1996 • 95 citations

Characterization of Glutamate-Gated Chloride Channels in the Pharynx of Wild-Type and MutantCaenorhabditis elegansDelineates the Role of the Subunit GluCl-α2 in the Function of the Native Receptor

2001 • 91 citations

Drosophilaγ‐Aminobutyric Acid Receptor Gene Rdl Shows Extensive Alternative Splicing

1993 • 81 citations

Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide ivermectin

2000 • 80 citations

Immunocytochemical mapping of a C-terminus anti-peptide antibody to the GABA receptor subunit, RDL in the nervous system of Drosophila melanogaster

1996 • 79 citations

GABA and Glutamate Receptors as Biochemical Sites for Insecticide Action

2001 • 78 citations

Stable expression of a functional homo-oligomeric Drosophila GABA receptor in a Drosophila cell line

1994 • 78 citations

Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes.

1987 • 77 citations

Diversification of Drosophila Chloride Channel Gene by Multiple Posttranscriptional mRNA Modifications

1999 • 77 citations

Two Distinct Nicotinic Receptors, One Pharmacologically Similar to the Vertebrate α7-Containing Receptor, Mediate Cl Currents inAplysiaNeurons

1998 • 77 citations

Nodulisporic Acid Opens Insect Glutamate-Gated Chloride Channels: Identification of a New High Affinity Modulator

2000 • 73 citations

Selective Histamine Uptake Rescues Photo- and Mechanoreceptor Function of Histidine Decarboxylase-DeficientDrosophilaMutant

1998 • 65 citations

Homology-based annotation yields 1,042 new candidate genes in the Drosophila melanogaster genome

2001 • 60 citations

Fipronil modulation of gamma-aminobutyric acid(A) receptors in rat dorsal root ganglion neurons.

2001 • 60 citations

An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans.

1998 • 60 citations

Alternative splicing of a Caenorhabditis elegans gene produces two novel inhibitory amino acid receptor subunits with identical ligand binding domains but different ion channels

1997 • 53 citations

Alternative splicing of a Drosophila GABA receptor subunit gene identifies determinants of agonist potency

2001 • 50 citations

Co-existence in DUM neurones of two GluCl channels that differ in their picrotoxin sensitivity

2000 • 49 citations

Properties of histamine-activated chloride channels in the large monopolar cells of the dipteran compound eye: a comparative study

1995 • 48 citations

Glutamate-gated inhibitory currents of central pattern generator neurons in the lobster stomatogastric ganglion

1995 • 47 citations

Anthelmintics and ion-channels: after a puncture, use a patch

1998 • 44 citations

L‐Glutamate activates excitatory and inhibitory channels in Drosophila larval muscle

1989 • 36 citations

Receptors for L-glutamate and GABA in the nervous system of an insect (Periplaneta americana)

1992 • 33 citations

Single channel analysis of the blocking actions of BIDN and fipronil on a Drosophila melanogaster GABA receptor (RDL) stably expressed in a Drosophila cell line

2000 • 33 citations

Identification of neuron-specific ivermectin binding sites in Drosophila melanogaster and Schistocerca americana

1995 • 32 citations

Cation Permeability and Cation-Anion Interactions in a Mutant GABA-Gated Chloride Channel from Drosophila

1999 • 28 citations

Two kinetically distinct 5-hydroxytryptamine-activated Cl- conductances at Retzius P-cell synapses of the medicinal leech

1995 • 25 citations

Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes

1995 • 21 citations

The β‐Subunit of Caenorhabditis elegans Avermectin Receptor Responds to Glycine and Is Encoded by Chromosome 1

1995 • 20 citations

Effects of putative neurotransmitters on dorsal unpaired median neurons of cockroach (Periplaneta americana) thoracic ganglia

1994 • 17 citations