Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists

The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury

1989 • 1,505 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Agonists and antagonists for excitatory amino acid receptors

1987 • 692 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil

1987 • 647 citations

The glutamate antagonist MK‐801 reduces focal ischemic brain damage in the rat

1988 • 547 citations

Experimental models of epilepsy

1973 • 526 citations

Non-competitive antagonists of excitatory amino acid receptors

1987 • 502 citations

Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 496 citations

Excitatory amino acid transmission

1987 • 430 citations

A potential role for excitotoxins in the pathophysiology of spinal cord injury

1988 • 377 citations

Protective Effect of the Glutamate Antagonist, MK-801 in Focal Cerebral Ischemia in the Cat

1988 • 370 citations

The NMDA Receptor

1995 • 356 citations

MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period

1988 • 276 citations

MK-801 protects the neonatal brain from hypoxic-ischemic damage

1987 • 261 citations

Excitatory amino acids in health and disease.

1988 • 254 citations

The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils

1988 • 246 citations

Central sympathomimetic activity of (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo [a, d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 229 citations

EXCITATORY AMINOACID ANTAGONISTS PROVIDE A THERAPEUTIC APPROACH TO NEUROLOGICAL DISORDERS

1985 • 217 citations

The novel anticonvulsant MK-801: a potent and specific ligand of the brain phencyclidine/gd-receptor

1987 • 197 citations

A simple model for studying benzodiazepines: Potentiation of hyperactivity induced by cocaine in mice

1982 • 193 citations

Kynurenate inhibition of cell excitation decreases stroke size and deficits

1987 • 189 citations

Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, papio papio

1983 • 179 citations

The excitatory amino acid antagonist kynurenic acid administered after hypoxic-ischemia in neonatal rats offers neuroprotection

1988 • 171 citations

Ketamine Effects on Local Cerebral Blood Flow and Metabolism in the Rat

1987 • 147 citations

Restoration of shock‐suppressed behavior by treatment with (+)‐5‐methyl‐10,11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic properties

1982 • 137 citations

Neurology and Neurobiology

1990 • 123 citations

Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents

1985 • 117 citations

2-amino-7-phosphonoheptanoic acid (AP7) produces discriminative stimuli and anticonflict effects similar to diazepam

1986 • 108 citations

Long-Term Development of Selective Neuronal Loss and the Mechanism of Protection by 2-Amino-7-Phosphonoheptanoate in a Rat Model of Incomplete Forebrain Ischaemia

1988 • 102 citations

Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-d-aspartic acid antagonism

1988 • 99 citations

Neurotransmitters and Epilepsy

1987 • 94 citations

Dextromethorphan protects against cerebral infarction in a rat model of hypoxia-ischemia

1988 • 92 citations

The effect of carbamazepine on cerebral glucose metabolism

1989 • 87 citations

Anticonvulsant properties of phencyclidine-like drugs in mice

1985 • 76 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Dextromethorphan and carbetapentane: centrally acting non-opioid antitussive agents with novel anticonvulsant properties

1986 • 74 citations

Effect of Phenytoin on Human Cerebral Glucose Metabolism

1986 • 71 citations

A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine

1987 • 71 citations

Alterations in local cerebral glucose utilization induced by phencyclidine

1987 • 68 citations

Differential effects of competitive and non-competitive antagonists on glucose use in the limbic system

1988 • 63 citations

CGS 19755 is a potent and competitive antagonist at NMDA-type receptors

1988 • 57 citations

Anticonvulsant action and biochemical effects in DBA/2 mice of CPP (3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate), a novel N-methyl-D-aspartate antagonist

1987 • 54 citations

Influence of pharmacological manipulation of inhibitory and excitatory neurotransmitter systems on seizure behavior in the Mongolian gerbil.

1985 • 53 citations

PCP‐induced alterations in cerebral glucose utilization in rat brain: Blockade by metaphit, a PCP‐receptor‐acylating agent

1987 • 50 citations

Antiepileptic and behavioural actions of MK-801 in an animal model of spontaneous absence epilepsy

1989 • 46 citations

Anticonvulsant effects of dextrorphan in rats: Possible involvement in dextromethorphan-induced seizure protection

1988 • 41 citations

The effect of MK‐801 on kindled seizures: Implications for use and limitations as an antiepileptic drug

1989 • 41 citations

The effect of diazepam upon local cerebral glucose use in the conscious rat

1986 • 41 citations

The competitive N-methyl-D-aspartate (NMDA) antagonist CGS 19755 attenuates the rate-decreasing effects of NMDA in rhesus monkeys without producing ketamine-like discriminative stimulus effects

1989 • 41 citations

The N-methyl-D-aspartate antagonist, 2-amino-7-phosphonoheptanoate, produces phencyclidine-like behavioral effects in rats

1987 • 40 citations

Uptake of a novel anticonvulsant compound, 2-amino-7-phosphono-[4,5-3H]Heptanoic acid, into mouse brain

1983 • 35 citations

Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice

1985 • 32 citations

Functional evidence for PCP-like effects of the anti-stroke candidate MK-801

1988 • 22 citations

Dramatic limbic and cortical effects mediated by high affinity PCP receptors

1988 • 17 citations

Epilepsy-Prone Mice Genetically Determined Sound-Induced Seizures

2003 • 9 citations

Effects of the GABA receptor agonist, progabide, upon local cerebral glucose utilization

1987 • 8 citations