Gastro-oesophageal reflux disease

Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma

1999 • 3,031 citations

Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification

1999 • 2,178 citations

Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota

1997 • 2,120 citations

Epidemiology of gastro-oesophageal reflux disease: a systematic review

2005 • 1,854 citations

The burden of selected digestive diseases in the United States

2002 • 1,486 citations

Meta-Analysis: Obesity and the Risk for Gastroesophageal Reflux Disease and Its Complications

2005 • 1,207 citations

Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease

2005 • 1,119 citations

An evidence-based appraisal of reflux disease management --- the Genval Workshop Report

1999 • 907 citations

Long-term Outcome of Medical and Surgical Therapies for Gastroesophageal Reflux Disease

2001 • 902 citations

Healing and relapse of severe peptic esophagitis after treatment with omeprazole

1988 • 792 citations

Symptoms in gastro-oesophageal reflux disease

1990 • 745 citations

Is there publication bias in the reporting of cancer risk in Barrett's esophagus?

2000 • 744 citations

Dysbiosis in inflammatory bowel disease

2003 • 707 citations

Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: Effect of omeprazole

2001 • 617 citations

Effect of peristaltic dysfunction on esophageal volume clearance

1988 • 580 citations

Role of acid and duodenogastroesophageal reflux in gastroesophageal reflux disease

1996 • 539 citations

Risk factors associated with symptoms of gastroesophageal reflux

1999 • 528 citations

Clinical esophageal pH recording: A technical review for practice guideline development

1996 • 490 citations

Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease

2013 • 479 citations

Gastroesophageal Reflux, Barrett Esophagus, and Esophageal Cancer

2002 • 472 citations

High prevalence of gastroesophageal reflux symptoms and esophagitis with or without symptoms in the general adult Swedish population: A Kalixanda study report

2005 • 450 citations

Effectiveness of proton pump inhibitors in nonerosive reflux disease

2004 • 449 citations

Opposing time trends of peptic ulcer and reflux disease

1998 • 381 citations

Continued (5-Year) Followup of A Randomized Clinical Study Comparing Antireflux Surgery and Omeprazole in Gastroesophageal Reflux Disease

2001 • 368 citations

The Relation of Gastroesophageal Reflux Disease and Its Treatment to Adenocarcinomas of the Esophagus and Gastric Cardia

1995 • 366 citations

Short-Term Treatment with Proton-Pump Inhibitors as a Test for Gastroesophageal Reflux Disease

2004 • 349 citations

Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease: systematic review

2003 • 337 citations

Barrett's metaplasia

2000 • 321 citations

Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia

2000 • 320 citations

Improvement of gastroesophageal reflux symptoms after radiofrequency energy: a randomized, sham-controlled trial

2003 • 319 citations

Evidence-Based Appraisal of Antireflux Fundoplication

2004 • 313 citations

Symptoms of gastro‐oesophageal reflux: prevalence, severity, duration and associated factors in a Spanish population

2003 • 292 citations

DOUBLE-BLIND MULTICENTRE COMPARISON OF OMEPRAZOLE AND RANITIDINE IN THE TREATMENT OF REFLUX OESOPHAGITIS

1987 • 282 citations

The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment – Prompt Endoscopy (CADET–PE) study

2003 • 280 citations

Omeprazole or Ranitidine in the Treatment of Reflux Esophagitis: Results of a Double-Blind, Randomized, Scandinavian Multicenter Study

1988 • 277 citations

Genetic influences in gastro-oesophageal reflux disease: a twin study

2003 • 274 citations

Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD.

1995 • 271 citations

Risk factors for Barrett's esophagus in community-based practice. GORGE consortium. Gastroenterology Outcomes Research Group in Endoscopy.

1997 • 267 citations

Gastro-oesophageal reflux treatment for asthma in adults and children

2003 • 262 citations

Gastroesophageal reflux disease in monozygotic and dizygotic twins

2002 • 257 citations

Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults

2011 • 255 citations

Natural history of gastroesophageal reflux disease and functional abdominal disorders: a population-based study

2001 • 250 citations

Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteers

2004 • 247 citations

The Stretta procedure for the treatment of GERD: 6 and 12 month follow-up of the U.S. open label trial

2002 • 244 citations

The pathogenesis of heartburn in nonerosive reflux disease: A unifying hypothesis

2005 • 242 citations

Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocarcinoma

1997 • 238 citations

Dilated Intercellular Spaces of Esophageal Epithelium in Nonerosive Reflux Disease Patients with Physiological Esophageal Acid Exposure

2005 • 233 citations

Epidemiology of Reflux Disease and Reflux Esophagitis

1989 • 231 citations

The Biopsy Diagnosis of Gastroesophageal Reflux Disease, “Carditis,” and Barrett's Esophagus, and Sequelae of Therapy

1996 • 230 citations

Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer.

2000 • 226 citations

No relation between body mass and gastro-oesophageal reflux symptoms in a Swedish population based study

2000 • 225 citations

Omeprazole and ranitidine in treatment of reflux oesophagitis: double blind comparative trial

1988 • 216 citations

Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects

2003 • 208 citations

Gastro‐oesophageal reflux disease in obesity: pathophysiological and therapeutic considerations

2002 • 206 citations

Mechanisms of acid reflux associated with cigarette smoking.

1990 • 205 citations

Effect of Esomeprazole on Nighttime Heartburn and Sleep Quality in Patients with GERD: A Randomized, Placebo-Controlled Trial

2005 • 204 citations

The prevalence of gastro‐oesophageal reflux symptoms in a UK population and the consultation behaviour of patients with these symptoms

2000 • 193 citations

Can the Clinical History Distinguish Between Organic and Functional Dyspepsia?

2006 • 193 citations

Heartburn severity underestimates erosive esophagitis severity in elderly patients with gastroesophageal reflux disease

2004 • 192 citations

Endocinch therapy for gastro-oesophageal reflux disease: a one year prospective follow up

2002 • 189 citations

Omeprazole (40 mg) is superior to ranitidine in short-term treatment of ulcerative reflux esophagitis

1988 • 185 citations

Step-down from multiple- to single-dose proton pump inhibitors (PPIs): a prospective study of patients with heartburn or acid regurgitation completely relieved with PPIs

2003 • 183 citations

Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial

2000 • 180 citations

Two doses of omeprazole versus placebo in symptomatic erosive esophagitis: The U.S. multicenter study

1992 • 176 citations

Overweight, but Not High Dietary Fat Intake, Increases Risk of Gastroesophageal Reflux Disease Hospitalization

1999 • 174 citations

Relationship of Overweight to Hiatus Hernia and Reflux Oesophagitis

1988 • 173 citations

Hiatal hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease

2001 • 171 citations

Oral cimetidine in reflux esophagitis: A double blind controlled trial

1978 • 169 citations

Clinical epidemiology and natural history of gastroesophageal reflux disease.

2000 • 167 citations

GERD pathogenesis, pathophysiology, and clinical manifestations.

2003 • 166 citations

Diagnostic and Therapeutic Use of Proton Pump Inhibitors in Non-Cardiac Chest Pain: A Metaanalysis

2005 • 164 citations

Ethnicity, Gender, and Socioeconomic Status as Risk Factors for Esophagitis and Barrett's Esophagus

2005 • 162 citations

Etiology of Dyspepsia: Four Hundred Unselected Consecutive Patients in General Practice

1995 • 162 citations

Sustained esophageal contraction: a motor correlate of heartburn symptom

2001 • 160 citations

A Prospective Study of the Diagnostic Accuracy of PillCam ESO Esophageal Capsule Endoscopy Versus Conventional Upper Endoscopy in Patients With Chronic Gastroesophageal Reflux Diseases

2005 • 146 citations

Studies of acid exposure immediately above the gastro-oesophageal squamocolumnar junction: evidence of short segment reflux

2004 • 144 citations

Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs

2004 • 143 citations

Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease

2010 • 136 citations

Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?

2005 • 135 citations

Prevalence, severity and associated features of gastro-oesophageal reflux and dyspepsia: a population-based study.

2000 • 133 citations

Interactions among Smoking, Obesity, and Symptoms of Acid Reflux in Barrett's Esophagus

2005 • 128 citations

Chocolate and heartburn: evidence of increased esophageal acid exposure after chocolate ingestion.

1988 • 127 citations

The Effect of Alcohol on Nocturnal Gastroesophageal Reflux

1987 • 125 citations

Yield of Repeat Wireless Video Capsule Endoscopy in Patients with Obscure Gastrointestinal Bleeding

2005 • 125 citations

Rabeprazole in treatment of acid peptic diseases: results of three placebo-controlled dose-response clinical trials in duodenal ulcer, gastric ulcer, and gastroesophageal reflux disease (GERD). The Rabeprazole Study Group.

1998 • 120 citations

National trends in utilization and outcomes of antireflux surgery

2003 • 120 citations

Medical treatments for the maintenance therapy of reflux oesophagitis and endoscopic negative reflux disease

2004 • 119 citations

Report of the Asia–Pacific consensus on the management of gastroesophageal reflux disease

2004 • 116 citations

Familial Clustering of Reflux Symptoms

1999 • 115 citations

Elevated Body Mass Disrupts the Barrier to Gastroesophageal Reflux

2001 • 114 citations

Reflux-Inducing Dietary Factors and Risk ofAdenocarcinoma of the Esophagus and Gastric Cardia

2000 • 109 citations

Management of gastro-oesophageal reflux disease in general practice

2001 • 107 citations

Comparison of barium radiology with esophageal pH monitoring in the diagnosis of gastroesophageal reflux disease.

1996 • 105 citations

Oral pantoprazole for erosive esophagitis: a placebo-controlled, randomized clinical trial

2000 • 101 citations

Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux

2005 • 100 citations

A comparison of lansoprazole and ranitidine in the treatment of erosive oesophagitis

1995 • 100 citations

Review article: gastro‐oesophageal reflux disease – the extent of the problem

2005 • 100 citations

Double blind comparison of omeprazole (40 mg od) versus cimetidine (400 mg qd) in the treatment of symptomatic erosive reflux oesophagitis, assessed endoscopically, histologically and by 24 h pH monitoring.

1990 • 90 citations

Ranitidine Therapy for Gastroesophageal Reflux Disease

1987 • 88 citations

Daily treatment with esomeprazole is superior to that taken on‐demand for maintenance of healed erosive oesophagitis

2005 • 87 citations

The Nationwide Frequency of Major Adverse Outcomes in Antireflux Surgery and the Role of Surgeon Experience, 1992–1997

2002 • 87 citations

The Usefulness of The Likelihood Ratio in The Diagnosis of Dyspepsia and Gastroesophageal Reflux Disease

1999 • 86 citations

Unsedated Peroral Endoscopy With a Video Ultrathin Endoscope: Patient Acceptance, Tolerance, and Diagnostic Accuracy

1998 • 85 citations

Famotidine Relieves Symptoms of Gastroesophageal Reflux Disease and Heals Erosions and Ulcerations

1991 • 84 citations

Effect of intraduodenal fat on lower oesophageal sphincter function and gastro-oesophageal reflux.

1997 • 84 citations

Evidence-Based Recommendations for Short- and Long-Term Management of Uninvestigated Dyspepsia in Primary Care: An Update of the Canadian Dyspepsia Working Group (CanDys) Clinical Management Tool

2005 • 84 citations

The effect of <scp>Helicobacter pylori</scp> and its eradication on gastro‐oesophageal reflux disease in patients with duodenal ulcers or reflux oesophagitis

2004 • 83 citations

Oral pantoprazole for erosive esophagitis: a placebo-controlled, randomized clinical trial

2000 • 82 citations

Geographical and ethnic differences in gastro‐oesophageal reflux disease

2004 • 81 citations

Risk factors for erosive reflux esophagitis: a case-control study

2001 • 80 citations

Prevalence of endoscopic reflux esophagitis among Koreans

2001 • 79 citations

Inhibitory effect of coffee on lower esophageal sphincter pressure

1980 • 77 citations

Different prevalences of reflux oesophagitis and hiatus hernia among dyspeptic patients in England and Singapore

1999 • 76 citations

Fundoplication and the Risk of Esophageal Cancer in Gastroesophageal Reflux Disease: A Veterans Affairs Cohort Study

2005 • 76 citations

Symptom relief in gastroesophageal reflux disease: a randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease.

2001 • 75 citations

Treatment of reflux esophagitis resistant to H2-receptor antagonists with lansoprazole, a new H+/K(+)-ATPase inhibitor: a controlled, double-blind study. Lansoprazole Study Group.

1993 • 75 citations

The pathogenesis of gastroesophageal reflux disease: the relationship between epithelial defense, dysmotility, and acid exposure.

1997 • 71 citations

Lansoprazole versus ranitidine for the treatment of reflux oesophagitis

1995 • 70 citations

Diagnosis of Symptomatic Gastroesophageal Reflux Disease

2003 • 70 citations

The Epidemiology of Gastroesophageal Reflux Disease

2003 • 69 citations

Extraesophageal Manifestations of GERD

2003 • 68 citations

Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project

2004 • 68 citations

Management of Dyspeptic Patients in Primary Care: Value of the Unaided Clinical Diagnosis and of Dyspepsia Subgrouping

1998 • 64 citations

Predicting endoscopie diagnosis in the dyspeptic patient

1996 • 61 citations

Rabeprazole versus ranitidine for the treatment of erosive gastroesophageal reflux disease: A double-blind, randomized clinical trial

2000 • 61 citations

The Clinical Benefit of Routine Upper Gastrointestinal Endoscopy

1986 • 59 citations

Systematic review: the efficacy of intermittent and on‐demand therapy with histamine H₂‐receptor antagonists or proton pump inhibitors for gastro‐oesophageal reflux disease patients

2005 • 58 citations

Do we know the cause of reflux disease?

1999 • 57 citations

A Placebo-Controlled Dose-Ranging Study of Lansoprazole in the Management of Reflux Esophagitis

1998 • 55 citations

Diagnostic Tests for Gastroesophageal Reflux Disease

2003 • 55 citations

Minimal change oesophagitis: a disease with characteristic differences to erosive oesophagitis

2005 • 54 citations

Ranitidine in the treatment of symptomatic gastroesophageal reflux disease.

1984 • 54 citations

Comparative Trial of Pantoprazole and Ranitidine in the Treatment of Reflux Esophagitis

1995 • 53 citations

Ranitidine in Reflux Oesophagitis

1984 • 51 citations

Double-Blind Crossover Study of Ranitidine and Placebo in Gastro-oesophageal Reflux Disease

1986 • 51 citations

Gastro‐oesophageal reflux disease in adults: Guidelines for clinicians

2002 • 49 citations

Patterns of Lower Esophageal Sphincter Function Associated With Gastroesophageal Reflux

1997 • 49 citations

Quality of life in acute and maintenance treatment of non‐erosive and mild erosive gastro‐oesophageal reflux disease

2005 • 49 citations

Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease

2004 • 48 citations

Systematic review: is there excessive use of proton pump inhibitors in gastro‐oesophageal reflux disease?

2004 • 48 citations

Pantoprazole 20 mg is effective for relief of symptoms and healing of lesions in mild reflux oesophagitis

1998 • 47 citations

Medical or Surgical Treatment for Chronic Gastro-oesophageal Reflux? A Systematic Review of Published Evidence of Effectiveness

2000 • 46 citations

Performance, Tolerability, and Symptoms Related to Prolonged pH Monitoring Using the Bravo System in Mexico

2005 • 46 citations

Prolonged pH Monitoring: Bravo Capsule

2005 • 46 citations

Efficacy and tolerability of 20 mg pantoprazole versus 300 mg ranitidine in patients with mild reflux-oesophagitis

2000 • 45 citations

Reflux symptoms in general practice: diagnostic evaluation of the Carlsson–Dent gastro‐oesophageal reflux disease questionnaire

2003 • 44 citations

Is Esophageal Capsule Endoscopy Feasible? Results of a Pilot

2003 • 42 citations

Endoscopic Gastric Plication (EndoCinch) for GERD: A Randomized, Sham-Controlled, Blinded, Single-Center Study

2004 • 42 citations

Ranitidine and placebo in the treatment of reflux oesophagitis: A double‐blind randomized trial

1983 • 42 citations

Comparison of Transesophageal Endoscopic Plication (TEP) with Laparoscopic Nissen Fundoplication (LNF) in the Treatment of Uncomplicated Reflux Disease

2006 • 40 citations

Rabeprazole versus ranitidine for the treatment of erosive gastroesophageal reflux disease: A double-blind, randomized clinical trial

2000 • 40 citations

CIMETIDINE IN THE TREATMENT OF REFLUX OESOPHAGITIS

1979 • 39 citations

Cimetidine in the treatment of severe ulcerative reflux oesophagitis; results of an 8-week double-blind study and of subsequent long-term maintenance treatment.

1980 • 39 citations

Standard‐dose lansoprazole is more effective than high‐dose ranitidine in achieving endoscopic healing and symptom relief in patients with moderately severe reflux oesophagitis

1999 • 38 citations

Ranitidine for erosive oesophagitis: a double‐blind, placebo‐controlled study

1992 • 38 citations

Omeprazole is superior to ranitidine plus metoclopramide in the short‐term treatment of erosive oesophagitis

1993 • 37 citations

The continuum of GERD complications.

2003 • 37 citations

A comparison of two doses of nizatidine versus placebo in the treatment of reflux oesophagitis

1990 • 35 citations

Comparison of the efficacy of pantoprazole vs. nizatidine in the treatment of erosive oesophagitis: a randomized, active‐controlled, double‐blind study

2002 • 32 citations

Randomized comparative study of omeprazole and famotidine in reflux esophagitis

2002 • 31 citations

Sufficient control of heartburn in endoscopy‐negative gastro‐oesophageal reflux disease trials

2003 • 30 citations

Ranitidine, 150 mg Three Times a Day, in the Treatment of Reflux Oesophagitis: A Placebo-Controlled, Double-Blind Study

1986 • 30 citations

Treatment of reflux oesophagitis of moderate and severe grade with ranitidine or pantoprazole—comparison of 24‐hour intragastric and oesophageal pH

1997 • 30 citations

Efficacy and tolerability of pantoprazole versus ranitidine in the treatment of reflux esophagitis and the influence of Helicobacter pylori infection on healing rate

2002 • 29 citations

Scoring system has better discriminative value than Helicobacter pylori testing in patients with dyspepsia in a setting with high prevalence of infection

2000 • 29 citations

Utility of Endoscopic Screening for Upper Gastrointestinal Adenocarcinoma

2000 • 28 citations

Pantoprazole Rapidly Improves Health-Related Quality of Life in Patients With Heartburn

2003 • 27 citations

Anxiety and depression are co-factors determining health care utilisation in patients with dyspepsia: a Hong Kong population based study.

1997 • 26 citations

New approaches to enhance the accuracy of the diagnosis of reflux disease

2004 • 26 citations

Cimetidine 800 mg Twice Daily for Healing Erosions and Ulcers in Gastroesophageal Reflux Disease

1990 • 25 citations

Treatment of reflux oesophagitis. A randomized, controlled evaluation of cimetidine.

1983 • 21 citations

Randomized, placebo‐controlled comparison of famotidine 20 mg b.d. or 40 mg b.d. in patients with erosive oesophagitis

1994 • 21 citations

Value of the unaided clinical diagnosis in dyspeptic patients in primary care

2001 • 20 citations

Daily treatment with esomeprazole is superior to that taken on-demand for maintenance of healed erosive oesophagitis

2005 • 18 citations

Treatment of reflux oesophagitis: A randomized, controlled evaluation of cimetidine

1983 • 17 citations

Ranitidine 300 mg twice daily and 150 mg four‐times daily are effective in healing erosive oesophagitis.

1996 • 16 citations

Definition and diagnosis of gastroesophageal reflux disease

2004 • 16 citations

Endoscopic treatments for gastro‐oesophageal reflux disease

2003 • 14 citations

Gastro-oesophageal Reflux Disease

2005 • 13 citations

A Blinded, Randomized, Sham-Controlled Trial of Endoscopic Gastroplication for the Treatment of Gastro-Esophageal Reflux Disease (GERD): Preliminary Results

2005 • 10 citations

Symptom relief in gastroesophageal reflux disease: a randomized, controlled comparison of pantoprazole and nizatidine in a mixed patient population with erosive esophagitis or endoscopy-negative reflux disease

2001 • 7 citations

Treatment of erosive reflux oesophagitis: a double-blind multicentre trial with nizatidine 300 mg b.i.d. versus placebo.

1992 • 6 citations

EnteryxS, an injectable treatment for GERD: multicenter results

2002 • 5 citations

Efficacy of pantoprazole compared with ranitidine in the treatment of gastroesophageal reflux disease: An open labeled randomized parallel and longitudinal comparative trial

2002 • 4 citations

Clinical efficacy and safety of pantoprazole versus ranitidine in patients with gastroesophageal reflux disease: Spanish multicenter study

2000 • 3 citations

Deleted Work

1955 • 0 citations